CAS 1332391-11-3

Formula: C20H13F4N5O2S

InChI: InChI=1S/C20H13F4N5O2S/c21-14-7-10(2-3-12(14)16(26)30)29-18(32)28(17(31)19(29)4-1-5-19)11-6-13(20(22,23)24)15(8-25)27-9-11/h2-3,6-7,9H,1,4-5H2,(H2,26,30)

InChI key: BAANHOAPFBHUDX-UHFFFAOYSA-N

SMILES: C1CC2(C1)C(=O)N(C(=S)N2C3=CC(=C(C=C3)C(=O)N)F)C4=CC(=C(N=C4)C#N)C(F)(F)F

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.

Formula: C₂₀H₁₃F₄N₅O₂S

Purezza: 98.6%

Colore e forma: Solid

Peso molecolare: 463.408

Ref: TM-T12146

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

N-Desmethyl-Apalutamide

Formula: C₂₀H₁₃F₄N₅O₂S

Purezza: ≥95%

Peso molecolare: 463.41

Ref: 54-BUP08683

N-Desmethyl Apalutamide

CAS: 1332391-11-3

Formula: C₂₀H₁₃F₄N₅O₂S

Colore e forma: White To Off-White Solid

Peso molecolare: 463.41

Ref: 4Z-A-284003

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

Formula: C₂₀H₁₃F₄N₅O₂S

Purezza: 98%

Peso molecolare: 463.4081

Ref: IN-DA01NV7R

N-Desmethyl Apalutamide

Prodotto controllato

CAS: 1332391-11-3

Applications N-Desmethyl Apalutamide has been exploresd asthiohydantion androgen receptor antagonist for treament of cancer
References Bignan, G.C. PCT Int. Appl. (2018), WO 2018037342 A1 20180301.

Formula: C₂₀H₁₃F₄N₅O₂S

Colore e forma: Neat

Peso molecolare: 463.41

Ref: TR-D291395

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzamide

Formula: C₂₀H₁₃F₄N₅O₂S

Purezza: 98%

Peso molecolare: 463.41

Ref: IN-DG01289413

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

Formula: C₂₀H₁₃F₄N₅O₂S

Peso molecolare: 463.4

Ref: BE-RMCA245002

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

Formula: C₂₀H₁₃F₄N₅O₂S

Peso molecolare: 463.41

Ref: ST-EA-CP-A92016

N-Desmethyl Apalutamide-d4

Prodotto controllato

CAS: 1332391-11-3

Formula: C₂₀D₄H₉F₄N₅O₂S

Colore e forma: Neat

Peso molecolare: 467.433

Ref: TR-D291398

N-Desmethyl Apalutamide D-13C215N

Prodotto controllato

CAS: 1332391-11-3

Formula: C₂C₁₈H₁₃F₄₁₅NN₄O₂S

Colore e forma: Neat

Peso molecolare: 466.387

Ref: TR-D291397

N-Desmethyl-apalutamide

CAS: 1332391-11-3

Apalutamide is a nonsteroidal antiandrogen that binds to the androgen receptor in prostate cancer cells. It has been shown to inhibit the proliferation of human prostate cancer cell lines and tumor xenografts in nude mice. Apalutamide is a potent inhibitor of protein interactions with the androgen receptor, which may be due to its ability to compete with testosterone for binding sites. It also has an activating effect on the androgen receptor, leading to increased transcription of genes regulated by this receptor.

Formula: C₂₀H₁₃F₄N₅O₂S

Purezza: Min. 95%

Peso molecolare: 463.4 g/mol

Ref: 3D-HDC39111