![S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidaz…](https://static.cymitquimica.com/cas-image/thumb-webp/387012-s-1-4-dimethylamino-3-methylphenyl-methyl-5-diphenylacetyl-4567-tetrahydro-1h-imidazo-45-c-pyridine-6-carboxylic-acid-hydrate-di-trifluoroacetate-salt.webp)
CAS 136676-91-0
:S-(+)-1-[(4-(Dimetilamino)-3-metilfenil)metil]-5-(difenilacetil)-4,5,6,7-tetraidro-1H-imidazo[4,5-c]piridina-6-acido carbossilico idrato di(trifluoroacetato) sale
Descrizione:
S-(+)-1-[(4-(Dimetilamino)-3-metilfenil)metil]-5-(difenilacetil)-4,5,6,7-tetraidro-1H-imidazo[4,5-c]piridina-6-acido carbossilico idrato di(trifluoroacetato) sale, con numero CAS 136676-91-0, è un composto organico complesso caratterizzato dalla sua unica struttura di imidazopiridina, che incorpora un telaio tetraidro. Questa sostanza presenta un gruppo funzionale acido carbossilico, contribuendo alle sue proprietà acide, ed è ulteriormente modificata dalla presenza di un gruppo dimetilamminico e di un moiety di difenilacetile, che possono influenzare la sua attività farmacologica. La forma di sale trifluoroacetato suggerisce una maggiore solubilità e stabilità, rendendola adatta per varie applicazioni, in particolare in chimica medicinale. La chiralità del composto, indicata dalla designazione S-(+), implica che potrebbe mostrare un'attività biologica specifica, influenzando potenzialmente la sua interazione con obiettivi biologici. In generale, la struttura intricata di questo composto e i suoi gruppi funzionali suggeriscono una potenziale utilità nello sviluppo di farmaci, in particolare nel contesto della neurofarmacologia o come agente terapeutico.
Formula:C31H32N4O32C2HF3O2
InChI:InChI=1S/C31H32N4O3.2C2HF3O2/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;2*3-2(4,5)1(6)7/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);2*(H,6,7)/t28-;;/m0../s1
InChI key:GPKQIEZLHVGJQH-ZXVJYWQYSA-N
SMILES:CC1=C(C=CC(=C1)CN2C=NC3=C2C[C@H](N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O
Sinonimi:- PD 123,319 hydrate di(trifluoroacetate) salt
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Trovati 7 prodotti.
(S)-1-(4-(Dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2)
CAS:(S)-1-(4-(Dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2)Formula:C35H34F6N4O7Purezza:99%Peso molecolare:736.67PD123319 Ditrifluoroacetate
CAS:Formula:C35H34F6N4O7Purezza:99%Colore e forma:SolidPeso molecolare:736.6575PD 123319 ditrifluoroacetate
CAS:PD 123319 ditrifluoroacetate is a selective non-peptide AT2 receptor antagonist with IC50 of 34 nM.Formula:C35H34F6N4O7Purezza:99%Colore e forma:White SolidPeso molecolare:736.66PD 123319 ditrifluoroacetate
CAS:(S)-1-(4-(Dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2)Formula:C35H34F6N4O7Purezza:99%Peso molecolare:736.66PD-123319 Bis(Trifluoroacetic Acid Salt) Hydrate
CAS:Prodotto controllatoApplications A selective and potent non-peptide angiotensin II type 2 (AT2) receptor antagonist. Potential treatment of cardiac hypertrophy as blockage of AT2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation. Studies show that it has protective effect against tumor necrosis factor-α-induced damage to human renal proximal tubular epithelial cells
References Carmeiros-Ramos, M.S. et al.: Bas. Res, Cardiol., 105, 325 (2010); Kagawa, T. et al.: Nephrol., 13, 309 (2008); Cohen, E.P. et al.: Transl. Res., 150, 106 (2007);Formula:C31H32N4O3·2C2HF3O2·xH2OColore e forma:NeatPeso molecolare:754.7PD 123,319 di(trifluoroacetate) salt hydrate
CAS:PD 123,319 di(trifluoroacetate) salt hydrate is a selective inhibitor of the neurokinin-1 receptor. In animal studies, PD 123,319 di(trifluoroacetate) salt hydrate has been shown to reduce hyperactivity and produce an antinociceptive effect by inhibiting the release of substance P from nerve terminals. The compound also has a protective effect on neurons and tissues in animals with traumatic brain injury. It also inhibits spontaneous pain behaviour in rats with cancer or experimental arthritis and reduces angiotensin-II induced hypertension in rats. br>br> PD 123,319 di(trifluoroacetate) salt hydrate binds to the neurokinin-1 receptor (NK1R). The NK1R is a G protein coupled receptor that is expressed on nociceptive neurons in the spinal cord and brainstem. NK1R activation induces the release of substance P from nerve terminals. SubstanceFormula:C31H32N4O3•(C2HF3O2)2•(H2O)xPurezza:Min. 95%Peso molecolare:736.66 g/mol
