CAS 137281-23-3

Pemetrexed

Descrizione:

Pemetrexed è un agente chemioterapico antifolato a più bersagli utilizzato principalmente nel trattamento di alcuni tipi di cancro, in particolare il cancro del polmone non a piccole cellule e il mesotelioma. Il suo meccanismo d'azione coinvolge l'inibizione di diversi enzimi nella via del folato, tra cui la timidilato sintasi, la diidrofolato reduttasi e la formiltransferasi del ribonucleotido di glicinamide, che sono cruciali per la sintesi del DNA e la proliferazione cellulare. Pemetrexed viene somministrato per via endovenosa ed è spesso somministrato in combinazione con altri agenti chemioterapici per aumentarne l'efficacia. Il farmaco è caratterizzato dalla sua complessità strutturale, con un anello pirimidinico e più gruppi funzionali che contribuiscono alla sua attività biologica. Gli effetti collaterali comuni includono mielosoppressione, disturbi gastrointestinali e affaticamento, richiedendo un attento monitoraggio durante il trattamento. Inoltre, i pazienti potrebbero aver bisogno di integrazione con acido folico e vitamina B12 per mitigare alcune delle tossicità del farmaco. In generale, Pemetrexed rappresenta un significativo progresso nella terapia mirata contro il cancro, dimostrando risultati migliori in specifiche popolazioni di pazienti.

Formula: C₂₀H₂₁N₅O₆

InChI: InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1

InChI key: InChIKey=WBXPDJSOTKVWSJ-ZDUSSCGKSA-N

SMILES: C(CC1=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C1)C=2C3=C(NC2)NC(N)=NC3=O

Sinonimi:

• (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid
• 1H-Pyrrolo[2,3-d]pyrimidine, <span class="text-smallcaps">L</span>-glutamic acid deriv.
• 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H pyrodo[2,3-d]Pyrimidin-5-yl)ethyl]-benzoic Acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• N-(4-(2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid
• N-(4-[2-(2-Amino-4,7-Dihydro-4-oxo-1H-pyrrolo)[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-Gluamic Acid
• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-Glutamic acid
• N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid
• NSC 698037
• Pefloxacinmesylate Pharma-0549
• Pemetrexed
• Pemetrexed Acid
• disodium (2R)-2-({4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}amino)pentanedioate
• L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-

Pemetrexed

CAS: 137281-23-3, 1916503-69-9

Formula: C₂₀H₂₁N₅O₆

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Blue powder to crystal

Peso molecolare: 427.42

Ref: 3B-P2288

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamicacid

CAS: 137281-23-3

Formula: C₂₀H₂₁N₅O₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 427.4106

Ref: IN-DA00131R

Pemetrexed Hydrate

CAS: 137281-23-3

Pemetrexed Hydrate

Formula: C₂₀H₂₁N₅O₆

Purezza: >99%

Colore e forma: Solid

Peso molecolare: 427.41

Ref: 54-OR1030044

Pemetrexed

CAS: 137281-23-3

Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).

Formula: C₂₀H₂₁N₅O₆

Purezza: 98.1% - 99.92%

Colore e forma: Solid

Peso molecolare: 427.41

Ref: TM-T0189

Pemetrexed

CAS: 137281-23-3

Pemetrexed

Formula: C₂₀H₂₁N₅O₆

Purezza: ≥98%

Peso molecolare: 427.41

Ref: 54-BUP17815

Pemetrexed

CAS: 137281-23-3

Formula: C₂₀H₂₁N₅O₆

Colore e forma: White To Off-White Solid

Peso molecolare: 427.42

Ref: 4Z-P-681

Pemetrexed

CAS: 137281-23-3

(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid

Formula: C₂₀H₂₁N₅O₆

Purezza: 99+%

Peso molecolare: 427.41

Ref: IN-DG146899

Pemetrexed

CAS: 137281-23-3

Formula: C₂₀H₂₁N₅O₆

Peso molecolare: 427.42

Ref: ST-EA-CP-P16000

Pemetrexed

CAS: 137281-23-3

Thymidylate synthase inhibitor; antifolate antineoplastic agent

Formula: C₂₀H₂₁N₅O₆

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 427.41 g/mol

Ref: 3D-FP37935

Pemetrexed-[13C5]

CAS: 137281-23-3

Ref: BE-MC-7261

Pemetrexed

CAS: 137281-23-3

(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid

Formula: C₂₀H₂₁N₅O₆

Purezza: 98% +(contains <4%EtOH)(Loss on drying≤6%)

Peso molecolare: 427.41

Ref: IN-DG01386674

Pemetrexed (Standard)

CAS: 137281-23-3

Pemetrexed (Standard) is a reference standard for research and analysis in studies involving Pemetrexed. Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).

Formula: C₂₀H₂₁N₅O₆

Colore e forma: Solid

Peso molecolare: 427.41

Ref: TM-TMSM-3442

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid

Prodotto controllato

CAS: 137281-23-3

Applications N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid, referred to as Pemetrexed, is used in the treatment of malignant pleural mesothelioma (MPM).
References Pasello, G. et al.: Anticanc. Res., 32, 5393 (2012);

Formula: C₂₀H₂₁N₅O₆

Colore e forma: Neat

Peso molecolare: 427.41

Ref: TR-A604980

Pemetrexed - Bio-X ™

CAS: 137281-23-3

Pemetrexed is a chemotherapy drug that belongs to the class of drugs called folate antimetabolites. It is used for the treatment of various cancers such as non-small cell lung cancer and pleural mesothelioma. Pemetrexed targets the enzymes thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. The drug works by inhibiting those enzymes so that the formation of DNA and RNA is prevented.

Formula: C₂₀H₂₁N₅O₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 427.41 g/mol

Ref: 3D-BP164240