CAS 138-14-7

Mesilato di deferoxamina

Descrizione:

Mesilato di deferoxamina è un agente chelante utilizzato principalmente nel trattamento delle condizioni di sovraccarico di ferro, come quelle derivanti da trasfusioni di sangue ripetute in pazienti con condizioni come talassemia o anemia falciforme. È un composto solubile in acqua che forma complessi stabili con ioni ferrici, facilitando la loro escrezione dal corpo. La sostanza è derivata dal batterio *Streptomyces pilosus* ed è caratterizzata dalla sua capacità di legarsi selettivamente al ferro, riducendo così la sua tossicità e prevenendo danni agli organi. Mesilato di deferoxamina viene tipicamente somministrato per via sottocutanea o endovenosa, e la sua farmacocinetica prevede una rapida distribuzione e escrezione renale. Il composto è noto per il suo profilo di tossicità relativamente basso, sebbene gli effetti collaterali potenziali possano includere reazioni allergiche, disturbi gastrointestinali ed effetti sulla vista con uso prolungato. La sua efficacia nella gestione del sovraccarico di ferro lo ha reso un agente terapeutico critico in ambito ematologico e oncologico.

Formula: C₂₅H₄₈N₆O₈·CH₄O₃S

InChI: InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)

InChI key: InChIKey=IDDIJAWJANBQLJ-UHFFFAOYSA-N

SMILES: S(C)(=O)(=O)O.C(CCC(NCCCCCN(C(C)=O)O)=O)(N(CCCCCNC(CCC(N(CCCCCN)O)=O)=O)O)=O

Sinonimi:

• Ba 33112
• Butanediamide, N⁴-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N¹-(5-aminopentyl)-N¹-hydroxy-, methanesulfonate (1:1)
• Butanediamide, N′-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate (salt)
• DFX mesylate
• Deferoxamine B mesylate
• Deferoxamine Mesilate
• Deferoxamine methanesulfonate
• Deferrioxamine B methanesulfonate
• Deferrioxamine methanesulfonate
• Desferal
• Desferal mesylate
• Desferrioxamine B mesylate
• Desferrioxamine B methanesulfonate
• Desferrioxamine mesilate
• Desferrioxamine mesylate
• Desferrioxamine methanesulfonate
• N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:1)
• N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:2)
• NSC 644468
• Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, methanesulfonate
• Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, monomethanesulfonate (salt)

Deferoxamine Mesylate

CAS: 138-14-7, 70-51-9

Formula: C₂₅H₄₈N₆O₈·CH₄O₃S

Purezza: >97.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 656.79

Ref: 3B-D4245

Desferrioxamine mesilate

CAS: 138-14-7

Desferrioxamine mesilate

Formula: C₂₇H₅₆N₆O₁₄S₂

Colore e forma: Off-White

Peso molecolare: 752.8953

Ref: 47-987

DEFEROXAMINE FOR PEAK IDENTIFICATION CRS

CAS: 138-14-7

DEFEROXAMINE FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0001937

DEFEROXAMINE MESILATE CRS

CAS: 138-14-7

DEFEROXAMINE MESILATE CRS

Formula: C₂₇H₅₆N₆O₁₄S₂

Peso molecolare: 752.8953

Ref: 41-D0160000

Deferoxamine Mesylate

CAS: 138-14-7

Non-aromatic organic derivatives of hydrazine or of hydroxylamine for use as drugs

Formula: C₂₅H₄₈N₆O₈·CH₄O₃S

Colore e forma: White Powder

Peso molecolare: 656.34148

Ref: 45-1166003

Deferoxamine mesylate

CAS: 138-14-7

Formula: C₂₆H₅₂N₆O₁₁S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 656.7897

Ref: IN-DA007ZDX

Deferoxamine Mesylate

CAS: 138-14-7

Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.

Formula: C₂₆H₅₂N₆O₁₁S

Purezza: 94.68% - 99.8%

Colore e forma: Solid

Peso molecolare: 656.79

Ref: TM-T1637

Deferoxamine Mesylate

CAS: 138-14-7

Deferoxamine Mesylate

Purezza: ≥90%

Peso molecolare: 656.79g/mol

Ref: 54-BUP17037

Deferoxamine mesylate

CAS: 138-14-7

Deferoxamine mesylate

Formula: C₂₅H₄₈N₆O₈·CH₃SO₃H

Purezza: By hplc: 99.0% by area (Typical Value in Batch COA)

Colore e forma: white solid

Peso molecolare: 656.79g/mol

Ref: 54-BIB6311

Desferrioxamine B mesylate

CAS: 138-14-7

Formula: C₂₅H₄₈N₆O₈·CH₄O₃S

Purezza: ≥ 98.0%

Colore e forma: White to almost white powder

Peso molecolare: 656.79

Ref: 7W-GP5073

Deferoxamine Mesilate RS

CAS: 138-14-7

Colore e forma: White Solid Powder

Ref: 2K-1086000021

Deferoxamine Mesylate

Prodotto controllato

CAS: 138-14-7

Applications An iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients
References Inati, A. et al.: Am. J. Hematol., 85, 782 (2010); Selim, M.: Translat. Stroke Res., 1, 35 (2010); Cappellini, M.D. et al.: Hemoblobin, 33, 258 (2009);

Formula: C₂₅H₄₈N₆O₈·CH₄O₃S

Colore e forma: Off-White

Peso molecolare: 656.79

Ref: TR-D228980

Deferoxamine mesylate

CAS: 138-14-7

Deferoxamine is a very well known drug for the treatment of iron excess occurring in patients with thalassemia who are receiving regular transfusions. Excessive iron intake from diet may also cause accumulation of the metal ions which result in several symptoms such as metabolic acidosis and hypovolemic shock. The mechanism of action of Deferoxamine is based on its ability to chelate iron and other metal ions (i.e. aluminum) permitting their rapid urinary elimination. Recently, another potential therapeutic uses of Deferoxamine for treating diabetic neuropathy was suggested since it was observed that the drug could activate the production of pro-angiogenic, neuroprotective and anti inflammatory factors. Read the full story here: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178011

Formula: C₂₆H₅₂N₆O₁₁S

Purezza: Min. 98.0 Area-%

Peso molecolare: 656.79 g/mol

Ref: 3D-D-0675

Deferoxamine mesylate

CAS: 138-14-7

Deferoxamine mesylate is an iron chelator that is used in the treatment of iron overload and to treat patients with chronic renal failure. Deferoxamine mesylate has been shown to inhibit angiogenesis by inhibiting the basic protein required for this process. It is also known to have a protective effect on myocardial cells, preventing cell death due to lack of oxygen (reactive oxygen species). Deferoxamine mesylate also inhibits neuronal death in a model system.
Deferoxamine mesylate binds to DNA and inhibits RNA synthesis, which has led to its use as a fluorescence probe for the detection of DNA binding activity. The drug has also been shown to act as a metal chelate, binding with metals such as iron, copper, and zinc.

Formula: C₂₆H₅₂N₆O₁₁S

Purezza: Min. 95 Area-%

Colore e forma: Powder

Peso molecolare: 656.79 g/mol

Ref: 3D-FD20885