CAS 1382481-79-9

Formula: C22H23NO3

InChI: InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1

InChI key: VSLWUPHHCFQTDB-LJQANCHMSA-N

SMILES: COC1=CC=C(C=C1)C#CC2=CC=C(C=C2)C(=O)N3CCC[C@H](C3)CO

ML289

CAS: 1382481-79-9

ML289

Formula: C₂₂H₂₃NO₃

Purezza: ≥98%

Peso molecolare: 349.42

Ref: 54-BUP10435

ML-289

CAS: 1382481-79-9

Formula: C₂₂H₂₃NO₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 349.4229

Ref: IN-DA00AAXU

ML289

CAS: 1382481-79-9

(R)-(3-(Hydroxymethyl)piperidin-1-yl)(4-((4-methoxyphenyl)ethynyl)phenyl)methanone

Formula: C₂₂H₂₃NO₃

Purezza: 98%

Peso molecolare: 349.42

Ref: IN-DG00806142

ML289

CAS: 1382481-79-9

ML289 is an allosteric modulator of metabotropic glutamate receptors (mGluRs). It has been shown to activate mGluR2/3 and mGluR4 in vitro. ML289 is a structural analog of the amino acid glutamate and binds to the same site as glutamate. This binding leads to increased signaling through these receptors, which are involved in many physiological processes, including myotonica and physiochemical functions. ML290 has been shown to be penetrant in vivo, with high brain concentrations achieved following peripheral administration. The pharmacokinetics of ML290 have also been characterized in rats, demonstrating that it is rapidly absorbed after oral administration and its concentration remains relatively stable over time. ML290 has also been shown to bind metal surfaces such as steel or nickel, making it a potential candidate for use on metal surfaces where bacteria may grow.

Formula: C₂₂H₂₃NO₃

Purezza: Min. 95%

Peso molecolare: 349.42 g/mol

Ref: 3D-HFC48179

ML289

CAS: 1382481-79-9

ML289 is a potent CNS-penetrant mGlu3 modulator with IC50 of 0.66 μM, >15-fold selectivity over mGlu2, and inactive against mGlu5.

Formula: C₂₂H₂₃NO₃

Purezza: 99.54%

Colore e forma: Yellow Solid

Peso molecolare: 349.42

Ref: TM-T23000