CAS 13870-90-1

Coenzima B12

Descrizione:

Coenzima B12, noto anche come metilcobalamina, è un cofattore vitale in vari processi biochimici, in particolare nel metabolismo dell'omocisteina e nella sintesi della metionina. È una vitamina solubile in acqua che appartiene al complesso delle vitamine B, specificamente al gruppo B12, che include diverse forme di cobalamina. Caratterizzato dalla sua struttura complessa, Coenzima B12 contiene un ion di cobalto al suo interno, coordinato a un anello di corrina, ed è distinto dalla presenza di un gruppo metile. Questo composto svolge un ruolo cruciale nel metabolismo cellulare, in particolare nel sistema nervoso centrale e nella formazione dei globuli rossi. La carenza di Coenzima B12 può portare a problemi di salute significativi, tra cui anemia e disturbi neurologici. Viene principalmente ottenuto attraverso fonti alimentari, in particolare prodotti di origine animale, ed è essenziale per mantenere una corretta funzione neurologica e la sintesi del DNA. Inoltre, Coenzima B12 è spesso utilizzato in contesti clinici per trattare carenze e condizioni di salute correlate.

Formula: C₇₂H₁₀₀CoN₁₈O₁₇P

InChI: InChI=1/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;-1;+3/p-2

InChI key: InChIKey=OAJLVMGLJZXSGX-RQKYJTTQSA-L

SMILES: [CH2-]([Co+3]1234[N]=5[C@@]6(C)[C@@]7([N-]1C([C@@](C)([C@H]7CC(N)=O)CCC(=O)NC[C@@H](C)OP(=O)([O-])O[C@H]8C(O)([C@@H](N9C=[N]2C=%10C9=CC(C)=C(C)C%10)O[C@@H]8CO)[H])=C(C)C%11=[N]3C(=CC%12=[N]4C(=C(C)C5[C@@H](CCC(N)=O)[C@@]6(CC(N)=O)C)[C@](CC(N)=O)(C)[C@@H]%12CCC(N)=O)C(C)(C)[C@@H]%11CCC(N)=O)[H])[C@H]%13O[C@H]([C@H](O)[C@@H]%13O)N%14C=%15C(N=C%14)=C(N)N=CN%15

Sinonimi:

• (5'-Deoxy-5'-adenosyl)cobamide coenzyme
• (5,6-Dimethylbenzimidazolyl)Cobamide Coenzyme
• 5'-Deoxy-5'-adenosylcobalamin
• 5'-Deoxyadenosyl vitamin B12
• 5'-Deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide
• 5'-Deoxyadenosylcobalamin
• 5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide
• 5,6-Dimethylbenzimidazolyl-Co-5'-deoxyadenosylcobamide
• 5′-Deoxyadenosyl vitamin B₁₂
• Actimide
• Adenosyl B12
• Adenosyl B₁₂
• Adenosylcobalamin
• Anabasi
• Betarin
• Calomide
• Cobalamin coenzyme
• Cobalamin, Co-(5'-deoxy-5'-adenosyl)-
• Cobalion
• Cobamamid
• Cobamamida
• Cobamamide
• Cobamide coenzyme, (5'-deoxy-5'-adenosyl)-
• Cobamide coenzyme, (5,6-dimethyl-1H-benzimidazolyl)-
• Cobamide, Co-(5'-deoxy-5'-adenosyl)-α-(5,6-dimethyl-1H-benzimidazolyl)-
• Cobanzyme
• Cobatlamin S
• Cobazymase
• Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosylbenzimidazole
• Cobinamide, Co-(5'-deoxyadenosine-5') derivative hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5′-deoxyadenosin-5′-yl)-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole-κN³)
• Cobinamide, Co-(5′-deoxyadenosine-5′) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5′-deoxyadenosine-5′) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosylbenzimidazole
• Coenzile
• Coenzyme B12
• Coenzyme B₁₂
• DBC
• DBC coenzyme
• Dbcc
• Deoxyadenosylcobalamin
• Dibencozide
• Dibenzcozamide
• Dimebenzcozamide
• Dolonevran
• Enzicoba
• Funacomide
• Heraclene
• Hi-Fresmin
• Hycobal
• Indusil
• Lm 176
• Represil
• Sabalamin
• Vitamin B12 coenzyme
• Vitamin B12, Co-(5'-deoxy-5'-adenosyl) deriv.
• Vitamin B₁₂ coenzyme
• Vitamin B₁₂, Co-(5′-deoxy-5′-adenosyl) deriv.
• Xobaline
• α-(5,6-Dimethylbenzimidazolyl)-Co-5'-deoxyadenosylcobamide
• α-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
• coenzyme B12 crystalline
• Cobinamide, Co-(5′-deoxyadenosin-5′-yl)-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3)
• adenosyl cobalamine
• 5μ-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
• DMBC COENZYME
• CobinaMide,Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate), inner salt, 3'-esterwith (5,6-diMethyl-1-a-D-ribofuranosyl-1H-benziMidazole-kN3) (9CI)
• ADENOSYLCOBALAMINE(COENZYME B12)(P)
• cobalaminecoenzyme
• Coenzyme B
• 2
• ADENOSYLCOBALAMINE(COENZYME B12)(RG)
• 5,6-DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME
• Cobamamide/VitaminB12
• Coenzyme B12,5′-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
• 5’-deoxyadenosylvitaminb12
• COBAMIDE
• COBAMAMIDE/DIBENCOZIDE
• DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME, 5,6-
• COBAMAMIDE (PYROGEN FREE)
• cobinamide,o-(5’-deoxyadenosine-5’)deriv.,hydroxide,dihydrogenphosphate(e
• ster),innersalt,3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidaz
• lm176
• ADENOSYLCOBALAMINE(COENZYME B12)(AS)
• 1
• dbccoenzyme
• COENZYME B12, >=97.0%

Cobamamide

CAS: 13870-90-1

Vitamin b12 (cyanocobalamin and related compounds with vitamin b12 activity) and its derivatives

Formula: C₇₂H₁₀₀CoN₁₈O₁₇P

Colore e forma: Powder

Peso molecolare: 1578.65834

Ref: 45-1142195

Adenosylcobalamin

CAS: 13870-90-1

AdoCbl is an active form of vitamin B12, a corrinoid, and cofactor for enzymes like methylmalonyl CoA mutase. Produced by select bacteria/archaea.

Formula: C₇₂H₁₀₀CoN₁₈O₁₇P

Purezza: 95.29% - 99.46%

Colore e forma: Solid

Peso molecolare: 1579.5818

Ref: TM-T14128

Coenzyme B12

CAS: 13870-90-1

Formula: C₇₂H₁₀₀CoN₁₈O₁₇P

Purezza: (HPLC) 98.0 - 102.0 % (dried basis)

Colore e forma: Dark red powder or crystalline powder

Peso molecolare: 1579.58

Ref: 7W-GP8985

Cobamamide (Dibencozide, Coenzyme B12)

CAS: 13870-90-1

Formula: C₇₂H₁₀₀CoN₁₈O₁₇P

Colore e forma: Red Solid

Peso molecolare: 1579.66

Ref: 4Z-C-161001

Cobamamide

Prodotto controllato

CAS: 13870-90-1

Formula: C₇₂H₁₀₀CoN₁₈O₁₇P

Colore e forma: Neat

Peso molecolare: 1579.58

Ref: 04-C11692190

Cobamamide

Prodotto controllato

CAS: 13870-90-1

Applications Cobamamide is an enzyme cofactor that can also regulate gene expression through RNA-base riboswitches.
References Ortiz-Guerrero, J.M., et. al.: P. Natl. Acad. Sci. USA, 108, 7565 (2011)

Formula: C₇₂H₁₀₀CoN₁₈O₁₇P

Colore e forma: Neat

Peso molecolare: 1579.58

Ref: TR-C633130

Coenzyme B12

CAS: 13870-90-1

Coenzyme B12, also known as vitamin B12, is a coenzyme that participates in the metabolism of amino acids and fatty acids. It is required for the conversion of homocysteine to methionine, which is an important step in the synthesis of S-adenosylmethionine (SAM), a major methyl donor. Coenzymes are required for many different reactions in cells, but they are not consumed during these reactions. Instead, they are regenerated and reused. Coenzyme B12 is synthesized by bacteria and archaea but not by animals. The cobalamin form of this coenzyme is made from cobaltous chloride or cobaltous sulfate and cyanide. This coenzyme has been shown to bind to riboswitches in bacteria and to ATP-binding cassette transporters in humans. Coenzyme B12 can exist in two different forms: adenosylcobalamin and methylcobalamin.

Formula: C₇₂H₁₀₀CoN₁₈O₁₇P

Purezza: Min. 97 Area-%

Colore e forma: Powder

Peso molecolare: 1,579.58 g/mol

Ref: 3D-FD65841