CAS 142880-36-2

Ilomastat

Descrizione:

Ilomastat, noto anche con il suo nome chimico, è un composto sintetico classificato come inibitore delle metaloproteinasi della matrice (MMP). È principalmente studiato per le sue potenziali applicazioni terapeutiche nel trattamento di varie malattie, tra cui il cancro e le condizioni fibrotiche. La sostanza agisce inibendo l'attività delle MMP, che sono enzimi coinvolti nella degradazione dei componenti della matrice extracellulare, influenzando così i processi di rimodellamento e riparazione dei tessuti. Ilomastat è stato studiato per la sua capacità di ridurre l'invasione tumorale e la metastasi limitando la degradazione della matrice extracellulare. In termini delle sue proprietà fisiche, Ilomastat è tipicamente caratterizzato dalla sua specifica struttura molecolare, che include gruppi funzionali che contribuiscono alla sua attività biologica. Il composto è solitamente somministrato in modo controllato in contesti clinici, e la sua farmacocinetica, inclusi assorbimento, distribuzione, metabolismo ed escrezione, è fondamentale per comprendere la sua efficacia e il profilo di sicurezza. La ricerca in corso continua a esplorare il suo pieno potenziale e i meccanismi d'azione in vari contesti terapeutici.

Formula: C₂₀H₂₈N₄O₄

InChI: InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1

InChI key: InChIKey=NITYDPDXAAFEIT-DYVFJYSZSA-N

SMILES: C([C@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)C(NC)=O)C=1C=2C(NC1)=CC=CC2

Sinonimi:

• (2R)-N⁴-Hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
• (2R)-N~4~-hydroxy-N~1~-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
• (R)-N1-((S)-3-(1H-indol-3yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide
• (R)-N4-Hydroxy-N1-[(S)-2-(1H-Indol-3-Yl)-1-Methylcarbamoly-Ethyl]-2-Isobutyl-Succinamide
• (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide
• Butanediamide, N⁴-hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-
• Butanediamide, N⁴-hydroxy-N¹-[1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, [S-(R*,S*)]-
• Cs 610
• Galardin
• Galardin Tm
• Galardin, GM6001, Ilomastat
• Gm 6001
• Butanediamide, N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-
• (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide

Ilomastat

CAS: 142880-36-2

Formula: C₂₀H₂₈N₄O₄

Purezza: >95.0%(HPLC)(qNMR)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 388.47

Ref: 3B-I1202

Ilomastat

CAS: 142880-36-2

Ilomastat

Formula: C₂₀H₂₈N₄O₄

Purezza: 98.5%

Peso molecolare: 388.46

Ref: 54-BUP12328

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(Methylamino)-1-Oxopropan-2-yl)-N4-Hydroxy-2-Isobutylsuccinamide

CAS: 142880-36-2

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(Methylamino)-1-Oxopropan-2-yl)-N4-Hydroxy-2-Isobutylsuccinamide

Formula: C₂₀H₂₈N₄O₄

Purezza: 98%

Peso molecolare: 388.46

Ref: 54-OR1023104

Illomastat

CAS: 142880-36-2

Formula: C₂₀H₂₈N₄O₄

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 388.4607

Ref: IN-DA00350G

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide

CAS: 142880-36-2

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide

Formula: C₂₀H₂₈N₄O₄

Purezza: 98%

Peso molecolare: 388.46

Ref: IN-DG134339

Ilomastat

CAS: 142880-36-2

Formula: C₂₀H₂₈N₄O₄

Peso molecolare: 388.50

Ref: 7W-GK4753

Ilomastat

CAS: 142880-36-2

Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.

Formula: C₂₀H₂₈N₄O₄

Purezza: 97.04% - 99.51%

Colore e forma: White Solid

Peso molecolare: 388.46

Ref: TM-T2743

Galardinᵀᴹ

CAS: 142880-36-2

Galardinâ„¢ is an experimental drug with inhibitory properties, which can be used as a potential drug target to treat various diseases. It inhibits the polymerase chain reaction by binding to the enzyme DNA polymerase and preventing its activity. Galardinâ„¢ also has been shown to have protective effects against oxidative injury in 3T3-L1 preadipocytes and protect cells from cell death by inhibiting toll-like receptor signaling pathways. In addition, it has antimicrobial activity against Candida glabrata and other bacterial strains, such as Staphylococcus aureus and Acinetobacter baumannii.

Formula: C₂₀H₂₈N₄O₄

Purezza: Min. 95%

Peso molecolare: 388.47 g/mol

Ref: 3D-INH-3927-PI

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide

CAS: 142880-36-2

Purezza: 95%+

Peso molecolare: 388.4679871

Ref: 10-F868898

Ilomastat

Prodotto controllato

CAS: 142880-36-2

Applications Ilomastat is a metalloprotease inhibitor.
References Dietrich, C., et. al.: J. Immunol., 192, 5382 (2014)

Formula: C₂₀H₂₈N₄O₄

Colore e forma: Neat

Peso molecolare: 388.46

Ref: TR-I267180

GM 6001

CAS: 142880-36-2

GM 6001 is a matrix that contains benzalkonium chloride. It is used as a pharmacological agent to prevent the growth of bacteria, fungi, and viruses. This product inhibits the synthesis of proteins that are required for cell division and may cause neuronal death. GM 6001 has been shown to inhibit the expression of matrix metalloproteinase-9 (MMP-9) in cultured cells, which may be due to its interference with the synthesis of proinflammatory cytokines such as tumor necrosis factor-α (TNF-α). GM 6001 also has potent immunosuppressive properties by inhibiting toll-like receptors (TLRs) in macrophages and dendritic cells. The TLRs are important for initiating immune responses against pathogens.

Formula: C₂₀H₂₈N₄O₄

Purezza: Min. 95%

Peso molecolare: 388.46 g/mol

Ref: 3D-SFA88036