CAS 1492-18-8

Folato di calcio

Descrizione:

Folato di calcio, noto anche come leucovorina o fattore citrovorum, è un sale di calcio dell'acido folinico, che è un derivato dell'acido folico. È comunemente usato in applicazioni mediche, in particolare come farmaco per ridurre gli effetti tossici di alcuni agenti chemioterapici, come il metotrexato, fornendo una fonte di folato ridotto. Questo composto è caratterizzato dalla sua apparenza cristallina bianca a gialla pallida ed è solubile in acqua, rendendolo adatto per somministrazione endovenosa o orale. Folato di calcio svolge un ruolo cruciale nel metabolismo cellulare, in particolare nella sintesi di acidi nucleici e aminoacidi, che sono essenziali per la divisione e la crescita cellulare. Il suo meccanismo d'azione implica la conversione in forme attive di folato, che possono eludere il blocco metabolico causato dai farmaci antifolato. Inoltre, è utilizzato nel trattamento dell'anemia megaloblastica e come terapia di supporto in vari trattamenti oncologici. I profili di sicurezza ed efficacia sono ben stabiliti, ma deve essere usato sotto supervisione medica a causa di potenziali interazioni con altri farmaci.

Formula: C₂₀H₂₃N₇O₇·Ca

InChI: InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/t12?,13-;/m0./s1

InChI key: InChIKey=BZPWXVJDMRBCMD-ZEDZUCNESA-N

SMILES: C(=O)N1C2=C(NCC1CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)NC(N)=NC2=O.[Ca]

Sinonimi:

• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
• Calcium 5-formyltetrahydrofolate
• Calcium <span class="text-smallcaps">L</span>-folinate
• Calcium Folinate
• Calcium Folinate(Folinic Acid)(Rg)
• Calcium L-Folinate
• Calcium leucovorin
• Calcium2-[4-[(2-Amino-5-Formyl-4-Oxo-1,6,7,8-Tetrahydropteridin-6-Yl)Methylamino]Benzoyl] Aminopentanedioate
• Calciumfolinat
• Folidan
• Folinate De Calcium
• Folinate-SF calcium
• Folinato Calcico
• Folinic acid Calcium salt
• Folinic acid calcium salt USP28
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), L-
• L-Calcium Folinate
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
• Lederfoline
• Leucovorin Calcium
• Leucovorin calcium salt
• LeucovorinCalcium
• Leucovorine calcium
• Nsc 3590
• Rescuvolin
• Wellcovorin
• calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate

Calcium Folinate

CAS: 1492-18-8, 2060570-47-8, 58-05-9, 6035-45-6

Formula: C₂₀H₂₁CaN₇O₇

Purezza: >98.0%(T)(HPLC)

Colore e forma: Light orange to Yellow to Green powder to crystaline

Peso molecolare: 511.51

Ref: 3B-C2235

Folinic acid calcium salt hydrate, 98%

CAS: 1492-18-8

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₂₀H₂₁CaN₇O₇

Purezza: 98%

Peso molecolare: 511.51

Ref: 02-H60181

CALCIUM FOLINATE CRS

CAS: 1492-18-8

CALCIUM FOLINATE CRS

Ref: 41-C0250000

CALCIUM FOLINATE (LEUCOVORIN CALCIUM) RS

CAS: 1492-18-8

CALCIUM FOLINATE (LEUCOVORIN CALCIUM) RS

Formula: C₂₀H₂₁CaN₇O₇

Peso molecolare: 511.5014

Ref: 41-ICRS0236

Calcium folinate

CAS: 1492-18-8

Calcium folinate

Formula: C₂₀H₂₁CaN₇O₇

Purezza: 75.0%

Colore e forma: Light Yellow

Peso molecolare: 511.11284

Ref: 47-923

Leucovorin Calcium

CAS: 1492-18-8

Other vitamins and their derivatives, nesoi

Formula: C₂₀H₂₁CaN₇O₇

Colore e forma: Yellow Powder

Peso molecolare: 511.11284

Ref: 45-1358004

L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)

CAS: 1492-18-8

Formula: C₂₀H₂₁CaN₇O₇

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 511.5014

Ref: IN-DA001LG9

Folinic acid calcium

CAS: 1492-18-8

Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.

Formula: C₂₀H₂₁CaN₇O₇

Purezza: 98.72% - >99.99%

Colore e forma: Yellow Crystalline Powder

Peso molecolare: 511.51

Ref: TM-T0148

Folinic acid calcium salt

CAS: 1492-18-8

Folinic acid calcium salt

Purezza: 98%

Colore e forma: Powder

Peso molecolare: 511.50143g/mol

Ref: 54-BIC0607

Folinic acid calcium salt hydrate

CAS: 1492-18-8

Formula: C₂₀H₂₁CaN₇O₇·xH₂O

Purezza: 97.5 - 102.5 % (anhydrous basis)

Colore e forma: Light-yellow to yellow-orange powder

Peso molecolare: 511.51 (anhydrous)

Ref: 7W-GP6553

Folinic acid calcium

CAS: 1492-18-8

Folinic acid calcium

Purezza: ≥98%

Peso molecolare: 511.51g/mol

Ref: 54-BUP17377

Folinic acid calcium salt hydrate, USP grade

CAS: 1492-18-8

Formula: C₂₀H₂₁CaN₇O₇·xH₂O

Purezza: (HPLC) 95.0 - 105.0 % (anhydrous substance)

Colore e forma: Yellow-white to yellow powder

Peso molecolare: 511.50 (anhydrous)

Ref: 7W-GV5663

Folinic Acid Calcium Salt ((6RS)-Calcium Levofolinate EP Impurity H Calcium Salt, Leucovorin Calcium Salt)

CAS: 1492-18-8

Formula: C₂₀H₂₁N₇O₇·Ca

Peso molecolare: 471.43 40.08

Ref: 4Z-F-068044

Folinate calcium 100 µg/mL in Water

CAS: 1492-18-8

Formula: C₂₀H₂₁N₇O₇·Ca

Colore e forma: Single Solution

Peso molecolare: 511.50

Ref: 04-A13888500WA-100

Folinate calcium

Prodotto controllato

CAS: 1492-18-8

Formula: C₂₀H₂₁N₇O₇·Ca

Colore e forma: Neat

Peso molecolare: 511.50

Ref: 04-C13888500

Calcium Folinate

CAS: 1492-18-8

Formula: C₂₀H₂₁N₇O₇·Ca

Colore e forma: Neat

Peso molecolare: 511.50

Ref: 86-MM0324.00

Calcium Folinate RS

CAS: 1492-18-8

Colore e forma: White To Light Yellow Solid Crystalline Powder

Ref: 2K-1154000021

Folinic Acid Calcium Salt

CAS: 1492-18-8

Stability Hygroscopic
Applications Folinic Acid Calcium Salt is a derivative of Folic Acid (F680300), a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. Has been shown to be partially effective in the treatment children suffering from autism spectrum disorders (ASDs).
References Frye, R. et al.: Mol. Psych., 18, 369 (2013); Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),

Formula: C₂₀H₂₁N₇O₇·Ca

Colore e forma: Light Yellow

Peso molecolare: 511.50

Ref: TR-F680320

Calcium folinate

CAS: 1492-18-8

Dihydrofolate reductase activator; decreases methotrexate toxicity

Formula: C₂₀H₂₁CaN₇O₇

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 511.50 g/mol

Ref: 3D-FC61510

Leucovorin calcium salt - Bio-X ™

CAS: 1492-18-8

Leucovorin is a folate analog drug that is used to treat the toxic effects of methotrexate and other antagonists of folate. It works by counteracting the toxic effects of methrotrexate by inhibiting the enzyme dihydrofolate reductase. It is used to increase the levels of folic acid and by strengthening the link between the active metabolite (5-FdUMP) and the enzyme thymidylate synthetase, leucovorin increases the action of fluorouracil. Additionally, in order to increase survival in patients undergoing palliative treatment for colorectal cancer, it is used in conjunction with 5-fluorouracil.

Formula: C₂₀H₂₃N₇O₇·Ca

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 513.52 g/mol

Ref: 3D-BC164621