CAS 58-05-9

Leucovorina

Descrizione:

Leucovorina, noto anche come acido folinico, è una forma ridotta dell'acido folico che svolge un ruolo cruciale in vari processi biochimici, in particolare nella sintesi degli acidi nucleici e degli aminoacidi. È comunemente usato in contesti medici come agente di salvataggio dopo la terapia con metotrexato, poiché può aiutare a mitigare gli effetti tossici del farmaco sulle cellule sane fornendo una fonte di folato attivo. Leucovorina è una polvere cristallina bianca o bianco sporco che è solubile in acqua, rendendola adatta per somministrazione endovenosa o orale. La sua struttura chimica include un anello di pteridina, un gruppo acido para-amminobenzoico e un residuo di acido glutammico, che contribuiscono alla sua attività biologica. Leucovorina è anche utilizzato in combinazione con fluorouracile per migliorare la sua efficacia nel trattamento di alcuni tumori. A causa del suo ruolo nel metabolismo cellulare, è essenziale per la corretta sintesi e riparazione del DNA, rendendolo vitale in contesti terapeutici e fisiologici.

Formula: C₂₀H₂₃N₇O₇

InChI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1

InChI key: InChIKey=VVIAGPKUTFNRDU-ABLWVSNPSA-N

SMILES: C(=O)N1C2=C(NCC1CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)NC(N)=NC2=O

Sinonimi:

• (6R,S)-5-Formyltetrahydrofolate
• 10-Formyl-7,8-dihydrofolic acid
• 5-Formyl-5,6,7,8-tetrahydrofolic acid
• 5-Formyltetrahydrofolic Acid
• 5-Formyltetrahydrofolsaure
• 5-Formyltetrahydropteroylglutamic acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Acide 5-Formyltetrahydrofolique
• Acido 5-Formiltetrahidrofolico
• CF
• Folinic acid
• Folinic acid-SF
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-
• Kunyrin
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Leucal
• Leucoverin
• Leucovorin
• Levoleucovorin
• N-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N5-Formyl-5,6,7,8-tetrahydrofolic acid
• N5-Formyltetrahydrofolic acid
• N⁵-Formyl-5,6,7,8-tetrahydrofolic acid
• N⁵-Formyl-THF
• N⁵-Formyltetrahydrofolic acid
• Welcovorin
• l-Leucovorin
• N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
• N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
• 5-formyltetrahydrofolate
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid
• N-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
• N5-formyl-5,6,7,8-tetrahydrofolate
• N5-formyl-tetrahydrofolate

Calcium Folinate

CAS: 1492-18-8, 2060570-47-8, 58-05-9, 6035-45-6

Formula: C₂₀H₂₁CaN₇O₇

Purezza: >98.0%(T)(HPLC)

Colore e forma: Light orange to Yellow to Green powder to crystaline

Peso molecolare: 511.51

Ref: 3B-C2235

Folinic acid

CAS: 58-05-9

Folinic acid

Formula: C₂₀H₂₃N₇O₇

Purezza: ≥98%

Peso molecolare: 473.44

Ref: 54-BUP11034

(2S)-2-[[4-[(2-Amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

CAS: 58-05-9

Formula: C₂₀H₂₃N₇O₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 473.4393

Ref: IN-DA003A0Z

Folinic Acid

CAS: 58-05-9

Folinic Acid

Formula: C₂₀H₂₃N₇O₇

Purezza: 98%

Peso molecolare: 473.44

Ref: 54-OR1027762

Folinic Acid

CAS: 58-05-9

Applications Folinic Acid is used in combination with 5-fluorouracil in the treatment of colorectal cancers. It also functions as a useful antidotal therapy medication for decreasing the toxic effect of methotrexate overdosing.
References He, J., et al.: Cancer Sci., 111, 253 (2020); Labriet, A., et al.: Pharmacogenomics, 20, 1179 (2019); Pannu, A. K.: Curr. Drug Metab., 20, 714 (2019)

Formula: C₂₀H₂₃N₇O₇

Colore e forma: Neat

Peso molecolare: 473.45

Ref: TR-F680340

Folinic acid

CAS: 58-05-9

Folinic acid (Leucovorin) is a biofolic acid that can be used in the treatment of methotrexate, often in combination with Methotrexate (MTX) to reduce MTX-

Formula: C₂₀H₂₃N₇O₇

Purezza: 99.76%

Colore e forma: Solid

Peso molecolare: 473.44

Ref: TM-T24403

Folinic acid

CAS: 58-05-9

Folinic acid is a vitamin-B9 that is used as a cofactor for enzymes involved in the synthesis of DNA and RNA. It is also used to diagnose various infectious diseases, with high values found in patients with cancer or autoimmune diseases. Folinic acid has been shown to have dose-dependent effects on mammalian cells, exhibiting toxicities at higher concentrations. Folinic acid can be used to repair damaged DNA by acting as a glycosidase that breaks down the glycosidic bond between the base and sugar.

Formula: C₂₀H₂₃N₇O₇

Purezza: (%) Min. 97%

Colore e forma: White Powder

Peso molecolare: 473.44 g/mol

Ref: 3D-FF156776

5-Formyltetrahydrofolic Acid-[13C5]

CAS: 58-05-9

Ref: BE-MC-0148

Folinic acid

CAS: 58-05-9

Folinic acid

Formula: C₂₀H₂₃N₇O₇

Purezza: 98%

Peso molecolare: 473.44

Ref: IN-DG105751

(2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid

CAS: 58-05-9

Purezza: 98%

Peso molecolare: 473.4460144

Ref: 10-F862514