CAS 155213-67-5

Ritonavir

Descrizione:

Ritonavir è un farmaco antiretrovirale utilizzato principalmente nel trattamento dell'HIV/AIDS. Appartiene alla classe degli inibitori della proteasi, che agiscono inibendo l'enzima proteasi, cruciale per il processo di replicazione virale. Ritonavir è caratterizzato dalla sua complessa struttura molecolare, che include una serie di gruppi funzionali che contribuiscono alla sua attività farmacologica. Viene tipicamente somministrato per via orale ed è noto per la sua capacità di aumentare l'efficacia di altri farmaci antiretrovirali quando utilizzato in terapia combinata. Ritonavir è anche notevole per il suo ruolo nel potenziamento farmacocinetico, dove aumenta la concentrazione plasmatica di altri inibitori della proteasi, consentendo dosi più basse e riducendo gli effetti collaterali. La sostanza è relativamente stabile in condizioni standard, ma deve essere conservata correttamente per mantenere la sua efficacia. Gli effetti collaterali comuni possono includere disturbi gastrointestinali, affaticamento e cambiamenti metabolici. A causa del suo ruolo significativo nei regimi di trattamento dell'HIV, Ritonavir è stato un componente critico nella gestione della malattia e nel miglioramento degli esiti per i pazienti.

Formula: C₄H₅NOS

InChI: InChI=1/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

InChI key: InChIKey=NCDNCNXCDXHOMX-XGKFQTDJSA-N

SMILES: [C@H](CC1=CC=CC=C1)(C[C@@H]([C@H](CC2=CC=CC=C2)NC(OCC3=CN=CS3)=O)O)NC([C@@H](NC(N(CC=4N=C(C(C)C)SC4)C)=O)[C@H](C)C)=O

Sinonimi:

• 1,3-Thiazol-5-Ylmethyl N-[(2S,3S,5R)-3-Hydroxy-5-[[(2S)-3-Methyl-2-[[Methyl-[(2-Propan-2-Yl-1,3-Thiazol-4-Yl)Methyl]Carbamoyl]Amino]Butanoyl]Amino]-1,6-Diphenyl-Hexan-2-Yl]Carbamate
• 2,4,7,12-Tetraazatridecan-13-oic acid, 10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)-
• 2,4,7,12-Tetraazatridecan-13-oic acid, 10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, [5S-(5R*,8R*,10R*,11R*)]-
• 2,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
• A 84538
• Abbott 84538
• Abt 538
• Empetus
• N-[(1S,3S,4S)-1-benzyl-3-hydroxy-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl]-N~2~-(methyl{[2-(1-methylethyl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
• N-[(2S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)valinamide
• NSC 693184
• Norvir
• Novir
• Ritomune
• Ritovir
• Viriton
• thiazol-5-ylmethyl (2S,3S,5S)-3-hydroxy-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-ylcarbamate
• Liponavir Core
• RITONAVIR
• Ethinyl Estradiol, Powder
• 2,4,7,12-Tetraazatridecan-13-oic acid, 10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)-(9CI)
• THIAZOL-5-YL-METHANOL
• CHEMBRDG-BB 4050354
• Norvi
• 1,3-THIAZOL-5-YLMETHANOL
• (3S,4S,6S,9S)-4-Hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid, 5-thiazolylmethyl Ester
• RARECHEM AL BD 1261
• 5-HYDROXYMETHYLTHIAZOLE

Ritonavir

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Purezza: >98.0%(HPLC)(N)

Colore e forma: White to Almost white powder to crystaline

Peso molecolare: 720.95

Ref: 3B-R0116

Ritonavir

CAS: 155213-67-5

Ritonavir

Formula: C₃₇H₄₈N₆O₅S₂

Purezza: 99.7%

Colore e forma: White. To. Off-White

Peso molecolare: 720.31276

Ref: 47-1210

RITONAVIR CRS

CAS: 155213-67-5

RITONAVIR CRS

Formula: C₃₇H₄₈N₆O₅S₂

Colore e forma: White. Powder.

Peso molecolare: 720.9442

Ref: 41-Y0000714

RITONAVIR FOR PEAK IDENTIFICATION CRS

CAS: 155213-67-5

RITONAVIR FOR PEAK IDENTIFICATION CRS

Formula: C₃₇H₄₈N₆O₅S₂

Peso molecolare: 720.9442

Ref: 41-Y0000706

RITONAVIR RS

CAS: 155213-67-5

RITONAVIR RS

Ref: 41-ICRS1421

Ritonavir Related Compounds Mixture

CAS: 155213-67-5

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Colore e forma: White Light Yellow Powder

Ref: 45-1604814

Ritonavir

CAS: 155213-67-5

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure

Formula: C₃₇H₄₈N₆O₅S₂

Colore e forma: White Tan Powder

Peso molecolare: 720.31276

Ref: 45-1604803

Ritonavir

CAS: 155213-67-5

Ritonavir (ABT 538) inhibits HIV-1/2 proteases; serum proteins limit it but it enhances other HIV drugs by hindering P450 degradation.

Formula: C₃₇H₄₈N₆O₅S₂

Purezza: 99.38% - 99.96%

Colore e forma: White Solid

Peso molecolare: 720.94

Ref: TM-T1525

Ritonavir

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 720.94

Ref: 7W-GP3714

Ritonavir

CAS: 155213-67-5

Ritonavir

Formula: C₃₇H₄₈N₆O₅S₂

Purezza: ≥98%

Peso molecolare: 720.94

Ref: 54-BUP17784

Ritonavir

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Colore e forma: White To Off-White Solid

Peso molecolare: 720.95

Ref: 4Z-R-271

Ritonavir

CAS: 155213-67-5

Colore e forma: Neat

Ref: 61-FOR1034.00

Ritonavir

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Purezza: 98.0%

Colore e forma: Solid

Peso molecolare: 720.95

Ref: 10-F358080

Ritonavir

Prodotto controllato

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Colore e forma: Neat

Peso molecolare: 720.94

Ref: 86-MM1034.00

Ritonavir

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Colore e forma: Neat

Peso molecolare: 720.94

Ref: 04-C16815300

Ritonavir

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Peso molecolare: 720.95

Ref: ST-EA-CP-R16000

Ritonavir

CAS: 155213-67-5

Applications A selective HIV protease inhibitor. It is a COVID19-related research product.
References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788 (2006)

Formula: C₃₇H₄₈N₆O₅S₂

Colore e forma: Neat

Peso molecolare: 720.94

Ref: TR-R535000

Ritonavir

CAS: 155213-67-5

Ritonavir has an anti-retroviral activity as it inhibits the protease enzymes specific of both HIV-1 and HIV-2. As an added functionality, ritonavir also inactivates significantly the cytochrome P4503A4 (CYP3A4) thus increasing the bioavailability or half-life of other co-administered drugs.

Formula: C₃₇H₄₈N₆O₅S₂

Purezza: Min. 95%

Colore e forma: White Off-White Powder

Peso molecolare: 720.95 g/mol

Ref: 3D-FR16561

Ritonavir - Bio-X ™

CAS: 155213-67-5

Ritonavir is a HIV protease inhibitor. It has an anti-retroviral activity as it inhibits the protease enzymes specific of both HIV-1 and HIV-2 and has been shown to be effective in controlling virus replication in humans and animals. Ritonavir works by preventing the HIV viral protease enzyme from cleaving the structural and replicative proteins produced by HIV genes such as gag and pol.

Formula: C₃₇H₄₈N₆O₅S₂

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 720.95 g/mol

Ref: 3D-BR164353

Ritonavir

CAS: 155213-67-5

Ref: BE-RMCR094000