CAS 1629268-00-3

Formula: C22H29ClN4O3

InChI: InChI=1S/C22H29ClN4O3/c1-3-20(29)27-13-15(14-27)25-6-8-26(9-7-25)21(30)12-24-18-10-16(22(2)4-5-22)17(23)11-19(18)28/h3,10-11,15,24,28H,1,4-9,12-14H2,2H3

InChI key: IPFOCHMOYUMURK-UHFFFAOYSA-N

SMILES: CC1(CC1)C2=CC(=C(C=C2Cl)O)NCC(=O)N3CCN(CC3)C4CN(C4)C(=O)C=C

ARS-853

CAS: 1629268-00-3

ARS-853

Formula: C₂₂H₂₉ClN₄O₃

Purezza: 98%

Peso molecolare: 432.94

Ref: 54-BUP07398

1-[3-[4-[2-[[4-Chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl]amino]acetyl]-1-piperazinyl]-1-azetidinyl]-2-propen-1-one

CAS: 1629268-00-3

Formula: C₂₂H₂₉ClN₄O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 432.9437

Ref: IN-DA01E2JY

ARS-853

CAS: 1629268-00-3

1-(3-(4-((4-Chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl)glycyl)piperazin-1-yl)azetidin-1-yl)prop-2-en-1-one

Formula: C₂₂H₂₉ClN₄O₃

Purezza: 98%

Peso molecolare: 432.94

Ref: IN-DG764621

ARS-853

CAS: 1629268-00-3

ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells

Formula: C₂₂H₂₉ClN₄O₃

Purezza: 97.43% - 98.4%

Colore e forma: Solid

Peso molecolare: 432.944

Ref: TM-T7414

ARS-853

Prodotto controllato

CAS: 1629268-00-3

Formula: C₂₂H₂₉ClN₄O₃

Colore e forma: Neat

Peso molecolare: 432.944

Ref: TR-A774050

ARS-853

CAS: 1629268-00-3

ARS-853 is a potent inhibitor of protein kinase C (PKC) and PKC-related enzymes. ARS-853 has been shown to be an activated, potent inhibitor of PKC in vivo in a mouse tumor model. The mechanism of inhibition is thought to be due to the binding of ARS-853 to the catalytic site of PKC, which blocks phosphatase activity. PKC inhibitors are used in cancer treatment because they help control cancer cell signaling pathways. ARS-853 has been shown to inhibit phosphatases, such as PTP1B, which regulate multiple cellular processes including glycogen synthesis, lipid metabolism, and insulin secretion.
Pharmacokinetic studies have shown that ARS-853 is rapidly absorbed from the gastrointestinal tract and eliminated primarily by hepatic metabolism with a half-life of about 2 hours.

Formula: C₂₂H₂₉ClN₄O₃

Purezza: Min. 95%

Peso molecolare: 432.94 g/mol

Ref: 3D-EQC26800