CAS 169590-42-5

Celecoxib

Descrizione:

Celecoxib è un farmaco antinfiammatorio non steroideo (FANS) utilizzato principalmente per il trattamento del dolore e dell'infiammazione associati a condizioni come l'artrite. Inibisce selettivamente l'enzima cicloossigenasi-2 (COX-2), che gioca un ruolo chiave nel processo infiammatorio, riducendo così la produzione di prostaglandine che mediano il dolore e l'infiammazione. Celecoxib è caratterizzato dalla sua formula chimica C17H14F3N3O2S e da un peso molecolare di circa 381,37 g/mol. Viene tipicamente somministrato per via orale ed è noto per i suoi effetti collaterali gastrointestinali relativamente inferiori rispetto ai FANS tradizionali, poiché risparmia l'enzima COX-1, coinvolto nella protezione della mucosa gastrica. Celecoxib è anche riconosciuto per i suoi potenziali rischi cardiovascolari, in particolare nell'uso a lungo termine, richiedendo una selezione e un monitoraggio attenti dei pazienti. La sostanza è generalmente ben assorbita, con concentrazioni plasmatiche massime che si verificano entro poche ore dopo la somministrazione, ed è metabolizzata principalmente nel fegato.

Formula: C₁₇H₁₄F₃N₃O₂S

InChI: InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)

InChI key: InChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C1=NN(C(=C1)C2=CC=C(C)C=C2)C3=CC=C(S(N)(=O)=O)C=C3

Sinonimi:

• 4-[5-((4-Methylphenyl)-3-TRIFLUORPMETHYL)-1H-pyrazol-YL]BENENESULFONAMIDE
• 4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)Pyrazol-1-Yl]Benzenesulfonamide
• 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
• 4-[5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
• 4-[[5-(4-Methylphenyl)-3-trifluoromethyl]-1H-pyrazol-yl]Benzenesulfonamide
• Benzenesulfonamide, 4-5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-
• Celebra-
• Celebrex
• Celecox
• Celocoxib
• Eurocox
• Medicoxib
• Onsenal
• Sc 58635
• Xilebao
• Ym 177

Celecoxib

CAS: 169590-42-5

Formula: C₁₇H₁₄F₃N₃O₂S

Purezza: >98.0%(HPLC)(T)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 381.37

Ref: 3B-C2816

CELECOXIB CRS

CAS: 169590-42-5

CELECOXIB CRS

Ref: 41-Y0001445

Celecoxib

CAS: 169590-42-5

Celecoxib

Formula: C₁₇H₁₄F₃N₃O₂S

Purezza: 99.7%

Colore e forma: White

Peso molecolare: 381.07588

Ref: 47-1230

Celecoxib

CAS: 169590-42-5

Sulfonamides used as drugs

Formula: C₁₇H₁₄F₃N₃O₂S

Colore e forma: Powder

Peso molecolare: 381.07588

Ref: 45-1098504

4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

CAS: 169590-42-5

Formula: C₁₇H₁₄F₃N₃O₂S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 381.3722

Ref: IN-DA00HZBR

Celecoxib

CAS: 169590-42-5

Celecoxib (SC 58635) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor.

Formula: C₁₇H₁₄F₃N₃O₂S

Purezza: 99.44% - 99.98%

Colore e forma: Solid

Peso molecolare: 381.372

Ref: TM-T0466

Celecoxib

CAS: 169590-42-5

Celecoxib

Formula: C₁₇H₁₄F₃N₃O₂S

Purezza: >98%

Peso molecolare: 381.37

Ref: 54-PC109244

Celecoxib

CAS: 169590-42-5

Formula: C₁₇H₁₄F₃N₃O₂S

Purezza: (Titration) 98.0 - 102.0 % (dried basis)

Colore e forma: White or almost white powder

Peso molecolare: 381.37

Ref: 7W-GP8233

Celecoxib

CAS: 169590-42-5

Formula: C₁₇H₁₄F₃N₃O₂S

Colore e forma: White To Off-White Solid

Peso molecolare: 381.37

Ref: 4Z-C-035

Celecoxib

CAS: 169590-42-5

Celecoxib

Formula: C₁₇H₁₄F₃N₃O₂S

Purezza: ≥98%

Peso molecolare: 381.37

Ref: 54-BUP15111

Celecoxib-d7 (tolyl-d7)

CAS: 169590-42-5, 544686-21-7

Purezza: 99 atom % D

Colore e forma: Off White To Yellow Solid

Peso molecolare: 388.41

Ref: 3U-D7317

Celecoxib

Prodotto controllato

CAS: 169590-42-5

Formula: C₁₇H₁₄F₃N₃O₂S

Colore e forma: Neat

Peso molecolare: 381.37

Ref: 04-C11066500

Celecoxib 1.0 mg/ml in Acetonitrile

CAS: 169590-42-5

Colore e forma: Single Solution

Ref: 61-AMP0344.00-11

Celecoxib

Prodotto controllato

CAS: 169590-42-5

Formula: C₁₇H₁₄F₃N₃O₂S

Colore e forma: Neat

Peso molecolare: 381.37

Ref: 86-MM0344.00

Celecoxib

Prodotto controllato

CAS: 169590-42-5

Applications Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. Celecoxib is also used in the treatment of hereditary polyps in the colon
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),

Formula: C₁₇H₁₄F₃N₃O₂S

Colore e forma: Neat

Peso molecolare: 381.37

Ref: TR-C251000

Celecoxib RS

CAS: 169590-42-5

Colore e forma: White

Ref: 2K-107670002

Celecoxib

CAS: 169590-42-5

Formula: C₁₇H₁₄F₃N₃O₂S

Peso molecolare: 381.37

Ref: ST-EA-CP-C13000

Celecoxib - Bio-X ™

Prodotto controllato

CAS: 169590-42-5

Celecoxib is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has been shown to inhibit prostaglandin synthesis and promote apoptosis in human osteosarcoma cells. Celecoxib also inhibits tumor growth and inhibits angiogenesis in combination with paclitaxel, which is a chemotherapeutic agent. It is a nonsteroidal anti-inflammatory drug, thus a beneficial treatment in conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, acute pain and juvenile rheumatoid arthritis. Furthermore it can be utilized in patients with familial adenomatous polyposis to reduce colon and rectal polyps.
Celecoxib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₇H₁₄F₃N₃O₂S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 381.37 g/mol

Ref: 3D-BC164295

Celecoxib

Prodotto controllato

CAS: 169590-42-5

Celecoxib-BioX TM is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has been shown to inhibit prostaglandin synthesis and promote apoptosis in human osteosarcoma cells. Celecoxib-BioX TM also inhibits tumor growth and inhibits angiogenesis in combination with paclitaxel, which is a chemotherapeutic agent. It is a nonsteroidal anti-inflammatory drug, thus a beneficial treatment in conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, acute pain and juvenile rheumatoid arthritis. Furthermore it can be utilized in patients with familial adenomatous polyposis to reduce colon and rectal polyps.

Formula: C₁₇H₁₄F₃N₃O₂S

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 381.37 g/mol

Ref: 3D-FC11300

Celecoxib

CAS: 169590-42-5

Formula: C₁₇H₁₄F₃N₃O₂S

Colore e forma: Solid

Peso molecolare: 381.4

Ref: BE-RMCC159000