CAS 16960-16-0

Tetracosactide

Descrizione:

Tetracosactide, noto anche come acetato di Tetracosactide, è un peptide sintetico che consiste in una sequenza di 24 aminoacidi, specificamente un frammento dell'ormone adrenocorticotropo (ACTH). È utilizzato principalmente in applicazioni mediche per la sua capacità di stimolare la corteccia surrenale, portando a un aumento della produzione di corticosteroidi. Tetracosactide è caratterizzato dal suo ruolo nei test diagnostici per l'insufficienza surrenalica e come agente terapeutico in condizioni come la sclerosi multipla e alcuni tipi di malattie infiammatorie. La sostanza è tipicamente somministrata per iniezione ed è nota per la sua vita media relativamente lunga rispetto ad altri derivati dell'ACTH. La sua struttura molecolare include un'organizzazione specifica di aminoacidi che contribuisce alla sua attività biologica, ed è spesso conservata in condizioni controllate per mantenere la stabilità. Come molti peptidi, Tetracosactide può mostrare variabilità nei suoi effetti in base al dosaggio e alla risposta individuale del paziente, richiedendo un attento monitoraggio durante il trattamento.

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

InChI: InChI=1/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1

SMILES: CC(C)[C@@H](C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=N[C@@H](C(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1ccc(cc1)O)C(=O)N1CCC[C@H]1C(=O)O)O)O)O)O)O)O)O)O)O)N=C([C@@H]1CCCN1C(=O)[C@H](CCCCN)N=C(CN=C([C@H](Cc1c[nH]c2ccccc12)N=C([C@H](CCCNC(=N)N)N=C([C@H](Cc1ccccc1)N=C([C@H](Cc1cnc[nH]1)N=C([C@H](CCC(=O)O)N=C([C@H](CCSC)N=C([C@H](CO)N=C([C@H](Cc1ccc(cc1)O)N=C([C@H](CO)N)O)O)O)O)O)O)O)O)O)O)O

Sinonimi:

• Cosyntropin
• L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline
• ACTH(1-24),human
• (1-24)α-ACTH
• 10: PN: WO03051390 PAGE: 52 claimed protein
• 1-24 ACTH (human)
• 1-24 Corticotropin (Human)
• 2136: PN: WO03060071 SEQID: 2198 unclaimed
• Acth1-24
• Actholain
• ACTHα1-24
• Adrenocorticotropin(1-24)
• Ba 30920
• Ba 36716
• Corticotropin-(1-24)
• Cortrophin S
• Cortrosinta
• Cortrosyn
• Human ACTH (1-24)
• L-Proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-α-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-
• Nuvacthen Depot
• PN: WO9952928 SEQID: 9 claimed protein
• Porcine ACTH (1-24)
• Synacthen
• Synacthene
• Synacthene-retard
• Synecthen
• Tetracosactid
• Tetracosactida
• Tetracosactrin
• Tetracosapeptide
• α1-24-ACTH
• α1-24-Adrenocorticotropic hormone
• α1-24-Corticotropin
• β1-24-ACTH
• β1-24-Corticotropin
• β1-24-Tetracosactide

ACTH (1-24) (human, bovine, rat)

CAS: 16960-16-0

Tetracosactide, a C-terminally truncated ACTH, still exhibits corticotropic activity, but it is less immunogenic than the full-length peptide hormone. The peptide induces an increase in the circulating level of glucocorticoids.

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purezza: 96.2%

Colore e forma: White

Peso molecolare: 2933.48

Ref: 01-4011958

Tetracosactide acetate

CAS: 16960-16-0

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purezza: ≥ 95% (dry, solvent free basis)

Colore e forma: White, off-white or pale yellow powder

Peso molecolare: 2933.44

Ref: 7W-GX2798

Tetracosactide Acetate

CAS: 16960-16-0

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purezza: 95%~99%

Colore e forma: White to Off-white Powder

Peso molecolare: 2933.44

Ref: BP-BPPG064

Tetracosactide

CAS: 16960-16-0

Tetracosactide, a synthetic peptide, mirrors the 24-amino acid start of ACTH with sequence SYSMEHFRWGKPVGKKRRPVKVYP.

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purezza: 99.91%

Colore e forma: Solid

Peso molecolare: 2933.44

Ref: TM-TP1031

α1-24-Adrenocorticotropic-d4 Hormone TFA Salt

Prodotto controllato

CAS: 16960-16-0

Applications α1-24-Adrenocorticotropic-d4 Hormone is the labeled analog of α1-24-Adrenocorticotropic Hormone (A305290), which is used in the treatment of West syndrome (WS).
References Munakata, M., et. al.: Tohoku J. Exp. Med., 232, 273 (2014);

Formula: C₁₃₆H₂₀₆D₄N₄₀O₃₁S•x(C₂HF₃O₂)

Colore e forma: Off-White

Peso molecolare: 2937.4611402

Ref: TR-A305292

ACTH (1-24), human

CAS: 16960-16-0

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Peso molecolare: 2,933.5 g/mol

Ref: 3D-PP50154

ACTH (Human 1-24)

CAS: 16960-16-0

ACTH (1-24) is a peptide hormone and neurotransmitter that belongs to the corticotropin-releasing factor family. It is also known as corticotropin-releasing hormone, adrenocorticotropic hormone, or CRH. ACTH binds to the ACTH receptor, which activates protein kinase A and cyclic AMP response element binding protein (CREB). Activation of these proteins leads to an increase in the production of cortisol. ACTH can be used as a research tool for studying ion channels and ligands. It can also be used as an antibody in cell biology research.

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purezza: Min. 95%

Peso molecolare: 2,933.4 g/mol

Ref: 3D-PAC-4109-V

ACTH (1-24), human

CAS: 16960-16-0

Custom research peptide; min purity 95%.

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purezza: Min. 95%

Peso molecolare: 2,933.5 g/mol

Ref: 3D-PA16890

Tetracosactide

CAS: 16960-16-0

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 2933.4370

Ref: IN-DA019FUR