CAS 187235-37-6

PA 824

Descrizione:

PA-824, con il numero CAS 187235-37-6, è un composto sintetico studiato principalmente per il suo potenziale utilizzo nel trattamento della tubercolosi, in particolare delle ceppi resistenti ai farmaci. Appartiene alla classe dei nitroimidazoli e mostra attività battericida contro Mycobacterium tuberculosis. PA-824 funziona attraverso un meccanismo d'azione unico, attivandosi in condizioni anaerobiche, portando alla generazione di specie reattive dell'azoto che interrompono i processi cellulari batterici. Questo composto è caratterizzato dalla sua capacità di penetrare efficacemente la parete cellulare micobatterica, rendendolo un candidato promettente nella terapia della tubercolosi. Inoltre, PA-824 ha mostrato proprietà farmacocinetiche favorevoli, inclusa la biodisponibilità orale e una vita media prolungata, che supportano il suo potenziale per regimi di dosaggio una volta al giorno. La ricerca continua a valutare la sua efficacia e sicurezza in contesti clinici, in particolare nelle terapie combinate mirate a migliorare i risultati del trattamento per i pazienti con tubercolosi multiresistente. In generale, PA-824 rappresenta un avanzamento significativo nella ricerca di agenti anti-tubercolosi efficaci.

Formula: C₁₄H₁₂F₃N₃O₅

InChI: InChI=1/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1

InChI key: InChIKey=ZLHZLMOSPGACSZ-NSHDSACASA-N

SMILES: N(=O)(=O)C1=CN2C(=N1)OC[C@@H](OCC3=CC=C(OC(F)(F)F)C=C3)C2

Sinonimi:

• (6S)-2-Nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• (6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine
• (S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• (S)-6-[[4-(Trifluoromethoxy)benzyl]oxy]-6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazine
• (S)-Pa 824
• 5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-, (6S)-
• 5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-, (S)-
• Pa-824
• Pretomanid
• EOS-60675
• PA-824, >=98%
• PA-824;PA824;PA 824
• (6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine PA-824
• 2-NITRO-6(S)-[4-(TRIFLUOROMETHOXY)BENZYLOXY]-6,7-DIHYDRO-5H-IMIDAZO[2,1-B][1,3]OXAZINE
• CS-930
• (S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine
• (S)-PA 824 (Pretomanid)
• (6S)-2-nitro-6-{[4-(trifluoromethoxy)phenyl]metho
• (S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 98+%
• PRETOMANID;(S)-PA 824
• (S)-6-(4-(trifluoromethoxy)benzyloxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• xy}-5H,6H,7H-imidazo[2,1-b][1,3]oxazine
• PA-824(Pretomanid)

PA-824

CAS: 187235-37-6

Formula: C₁₄H₁₂F₃N₃O₅

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 359.26

Ref: 3B-P2718

Pretomanid

CAS: 187235-37-6

Pretomanid

Formula: C₁₄H₁₂F₃N₃O₅

Purezza: ≥98%

Colore e forma: Solid

Peso molecolare: 359.26

Ref: 54-BUP06246

(6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

Formula: C₁₄H₁₂F₃N₃O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 359.2574

Ref: IN-DA0074WJ

Pretomanid (PA-824)

CAS: 187235-37-6

Formula: C₁₄H₁₂F₃N₃O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 359.26

Ref: 4Z-P-138001

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Formula: C₁₄H₁₂F₃N₃O₅

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 359.25738

Ref: 54-PC400580

PA-824

CAS: 187235-37-6

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Formula: C₁₄H₁₂F₃N₃O₅

Purezza: 99%

Peso molecolare: 359.26

Ref: IN-DG289955

Pretomanid

CAS: 187235-37-6

Pretomanid ((S)-PA 824) , a nitroimidazole, is used as an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.

Formula: C₁₄H₁₂F₃N₃O₅

Purezza: 98.75% - 99.96%

Colore e forma: Solid

Peso molecolare: 359.26

Ref: TM-T6096

Pretomanid

CAS: 187235-37-6

Formula: C₁₄H₁₂F₃N₃O₅

Peso molecolare: 359.26

Ref: ST-EA-CP-P30000

(S)-PA 824 (Pretomanid)

Prodotto controllato

CAS: 187235-37-6

Applications A novel anti-tuberculosis drug.
References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);

Formula: C₁₄H₁₂F₃N₃O₅

Colore e forma: Neat

Peso molecolare: 359.26

Ref: TR-P122500

(S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

(S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine ia slo known as PA-824. An anti-tuberculosis drug that affects both replicating and non-replicating Mycobacterium tuberculosis via cell wall inhibition and respiratory poisoning..

Formula: C₁₄H₁₂F₃N₃O₅

Purezza: Min. 98 Area-%

Colore e forma: Off-White Slightly Yellow Powder

Peso molecolare: 359.26 g/mol

Ref: 3D-FP26721

Pretomanid

CAS: 187235-37-6

Ref: BE-MU-7934

Pretomanid

CAS: 187235-37-6

Ref: BE-RMCP318001

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

Formula: C₁₄H₁₂F₃N₃O₅

Purezza: 98%

Colore e forma: Liquid, No data available.

Peso molecolare: 359.261

Ref: 10-F462409

Pretomanid (Standard)

CAS: 187235-37-6

Pretomanid (Standard) is a reference standard for research and analysis in studies involving Pretomanid. Pretomanid ((S)-PA 824) , a nitroimidazole, is used as an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.

Formula: C₁₄H₁₂F₃N₃O₅

Colore e forma: Solid

Peso molecolare: 359.26

Ref: TM-TMSM-3604