CAS 1873373-33-1

Formula: C20H19F5N4O4

InChI: InChI=1S/C20H19F5N4O4/c1-27-18(31)12-7-14(17(26)28-8-12)32-15-9-29(10-19(15,21)22)16(30)6-11-2-4-13(5-3-11)33-20(23,24)25/h2-5,7-8,15H,6,9-10H2,1H3,(H2,26,28)(H,27,31)/t15-/m0/s1

InChI key: FTAFQADCGCSJAH-HNNXBMFYSA-N

SMILES: CNC(=O)C1=CC(=C(N=C1)N)O[C@H]2CN(CC2(F)F)C(=O)CC3=CC=C(C=C3)OC(F)(F)F

6-amino-5-{[(3S)-4,4-difluoro-1-{2-[4-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl]oxy}-N-methylpyridine-3-carboxamide

CAS: 1873373-33-1

6-amino-5-{[(3S)-4,4-difluoro-1-{2-[4-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl]oxy}-N-methylpyridine-3-carboxamide

Formula: C₂₀H₁₉F₅N₄O₄

Purezza: 95%

Peso molecolare: 474.3822

Ref: 54-PC1051806

Trk-in-3

CAS: 1873373-33-1

Trk-in-3 is an inhibitor specifically targeting tyrosine kinase receptors, derived from a combination of synthesized natural compounds. This inhibitor functions by selectively binding to the ATP-binding site of Trk receptors, thus disrupting downstream signaling pathways that are crucial for cellular proliferation and survival.

Formula: C₂₀H₁₉F₅N₄O₄

Purezza: Min. 95%

Peso molecolare: 474.4 g/mol

Ref: 3D-YZC37333

PF-06733804

CAS: 1873373-33-1

PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.

Formula: C₂₀H₁₉F₅N₄O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 474.38

Ref: TM-T13207