CAS 19210-12-9

Arpagoside

Descrizione:

Arpagoside è un glicoside iridoide che si trova naturalmente principalmente nelle radici della pianta Harpagophytum procumbens, comunemente nota come artiglio del diavolo. È caratterizzato dalla sua formula molecolare, che include atomi di carbonio, idrogeno e ossigeno, riflettendo la sua struttura glicosidica. Arpagoside è noto per le sue potenziali proprietà antinfiammatorie e analgesiche, rendendolo di interesse nella medicina erboristica e negli integratori alimentari, in particolare per condizioni come l'artrite e il dolore articolare. Il composto presenta un sapore amaro ed è spesso estratto per l'uso in varie formulazioni. In termini di solubilità, Arpagoside è generalmente solubile in acqua e solventi organici, il che facilita la sua estrazione e incorporazione in vari prodotti. I suoi effetti farmacologici sono attribuiti alla sua capacità di modulare le vie infiammatorie e influenzare la percezione del dolore. Come molti composti naturali, l'efficacia e la sicurezza di Arpagoside possono variare in base al dosaggio e alla risposta individuale, rendendo necessaria ulteriore ricerca per comprendere appieno il suo potenziale terapeutico e i meccanismi d'azione.

Formula: C₂₄H₃₀O₁₁

InChI: InChI=1S/C24H30O11/c1-23(35-16(27)8-7-13-5-3-2-4-6-13)11-15(26)24(31)9-10-32-22(20(23)24)34-21-19(30)18(29)17(28)14(12-25)33-21/h2-10,14-15,17-22,25-26,28-31H,11-12H2,1H3/b8-7+/t14-,15-,17-,18+,19-,20-,21+,22+,23+,24-/m1/s1

InChI key: InChIKey=KVRQGMOSZKPBNS-FMHLWDFHSA-N

SMILES: O[C@@]12[C@@]([C@](OC(/C=C/C3=CC=CC=C3)=O)(C)C[C@H]1O)([C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)OC=C2)[H]

Sinonimi:

• (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl β-<span class="text-smallcaps">D</span>-glucopyranoside
• (1S,4aS,5R,7S,7aS)-1-(beta-D-glucopyranosyloxy)-4a,5-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl (2E)-3-phenylprop-2-enoate
• (1S-(1alpha,4aalpha,5alpha,7alpha(E),7aalpha))-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-((allyl-1-oxo-3-phenyl)oxy)cyclopenta(c)pyran-1-yl-beta-D-glucopyranoside
• 1-(Hexopyranosyloxy)-4A,5-Dihydroxy-7-Methyl-1,4A,5,6,7,7A-Hexahydrocyclopenta[C]Pyran-7-Yl 3-Phenylprop-2-Enoate
• E-Harpagoside
• Hapagoside
• Harpagoside
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propenyl]oxy]cyclopenta[c]pyran-1-yl
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, 1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[(1-oxo-3-phenyl-2-propenyl)oxy]cyclopenta[c]pyran-1-yl, [1S-[1α,4aα,5α,7α(E),7aα]]-
• β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propenyl]oxy]cyclopenta[c]pyran-1-yl
• (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl β-D-glucopyranoside
• β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl

Harpagoside

CAS: 19210-12-9

Harpagoside analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₂₄H₃₀O₁₁

Purezza: (HPLC) ≥98%

Colore e forma: Powder

Peso molecolare: 494.49

Ref: 11-0229S

HARPAGOSIDE CRS

CAS: 19210-12-9

HARPAGOSIDE CRS

Ref: 41-Y0000673

Harpagoside

CAS: 19210-12-9

Formula: C₂₄H₃₀O₁₁

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 494.4884

Ref: IN-DA0074IX

Harpagoside

CAS: 19210-12-9

Harpagoside

Purezza: ≥95%

Peso molecolare: 494.49g/mol

Ref: 54-BUP11439

Harpagoside

CAS: 19210-12-9

Harpagoside

Purezza: 98%

Peso molecolare: 494.49g/mol

Ref: 54-OR1022943

Harpagoside

CAS: 19210-12-9

Ref: 7W-GC8133

Harpagoside

CAS: 19210-12-9

Formula: C₂₄H₃₀O₁₁

Colore e forma: Pale Yellow Solid

Peso molecolare: 494.49

Ref: 4Z-H-063001

Harpagoside

CAS: 19210-12-9

Formula: C₂₄H₃₀O₁₁

Purezza: >95.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 494.49

Ref: 3B-H1849

Harpagoside

CAS: 19210-12-9

Harpagoside has anti-inflammatory effects, it blocks lipopolysaccharide (LPS)-induced bone loss in an inflammatory osteoporosis model, and it does not prevent ovariectomy-mediated bone erosion in a postmenopausal osteoporosis model, it may lead to a partial prevention of obesity-induced atherosclerosis by attenuating inflammatory responses. Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-κB activation. Harpagoside exerts neuroprotection effect and ameliorates learning and memory deficit appears to be associated, at least in part, with up-regulation of brain-derived neurotrophic factor (BDNF) content as well as activating its downstream signaling pathways, e.g., MAPK/PI3K pathways.

Formula: C₂₄H₃₀O₁₁

Purezza: 95%~99%

Peso molecolare: 494.493

Ref: BP-BP0702

Harpagoside

CAS: 19210-12-9

Harpagoside: anti-inflammatory; 3 mM inhibits seed germination; reduces COX-2, iNOS mRNA, and protein in HepG2.

Formula: C₂₄H₃₀O₁₁

Purezza: 99.71% - ≥95%

Colore e forma: White To Off-White Powder

Peso molecolare: 494.49

Ref: TM-T6S2023

Harpagoside-d5

CAS: 19210-12-9

Formula: C₂₄H₂₅D₅O₁₁

Peso molecolare: 499.52

Ref: 4Z-H-063002

Harpagoside

CAS: 19210-12-9

Natural glycoside

Formula: C₂₄H₃₀O₁₁

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 494.5

Ref: 5G-89218

Harpagoside

CAS: 19210-12-9

Applications Harpagoside is an iridoid glycoside along with with Harpagide (H105270), the potential to be strong anti-inflammatory agents providing the bulk of the observed effects from their plant origins.
References Zhang, L. et al.: Bioorg Med. Chem., 19, 4882 (2011); Wen, B. et al.: J. Ethnopharm., 147, 503 (2013);

Formula: C₂₄H₃₀O₁₁

Colore e forma: Neat

Peso molecolare: 494.49

Ref: TR-H105275

Harpagoside

CAS: 19210-12-9

Harpagoside is a bioactive compound, which is an iridoid glycoside derived from the root of the plant Harpagophytum procumbens, commonly known as Devil’s Claw. This compound is predominantly sourced from Southern Africa, where the plant is native to semi-arid regions and has been traditionally used in herbal medicine.

Formula: C₂₄H₃₀O₁₁

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 494.5 g/mol

Ref: 3D-MH08976

HARPAGOSIDE

CAS: 19210-12-9

Purezza: 99%

Peso molecolare: 494.4930115

Ref: 10-F858514

Harpagoside-D5

Prodotto controllato

CAS: 19210-12-9

Applications Harpagoside-D5 is an isotope labelled analog of Harpagoside (H105275). Harpagoside is an iridoid glycoside along with with Harpagide (H105270), the potential to be strong anti-inflammatory agents providing the bulk of the observed effects from their plant origins.
References Zhang, L. et al.: Bioorg Med. Chem., 19, 4882 (2011); Wen, B. et al.: J. Ethnopharm., 147, 503 (2013);

Formula: C₂₄D₅H₂₅O₁₁

Colore e forma: Neat

Peso molecolare: 499.519

Ref: TR-H105277