CAS 1968-05-4

3,3'-Diindolilmetano

Descrizione:

3,3'-Diindolilmetano (DIM) è un composto organico derivato dall'indolo, formato specificamente attraverso la dimerizzazione dell'indolo-3-carbinolo, che si trova nelle verdure crucifere come broccoli e cavoletti di Bruxelles. È caratterizzato dai suoi due anelli di indolo collegati da un ponte di metilene. Il DIM è noto per i suoi potenziali benefici per la salute, in particolare nel contesto della prevenzione del cancro e dell'equilibrio ormonale, poiché può influenzare il metabolismo degli estrogeni ed esibire proprietà anti-infiammatorie. Il composto è tipicamente un solido cristallino di colore giallo-arancio ed è solubile in solventi organici, ma ha una solubilità limitata in acqua. La sua formula molecolare è C18H16N2 e ha un peso molecolare relativamente basso. Il DIM ha suscitato interesse nella ricerca nutrizionale e farmaceutica grazie alle sue proprietà bioattive, e gli studi hanno esplorato il suo ruolo nella modulazione di vari percorsi biologici, inclusa l'apoptosi e la regolazione del ciclo cellulare. Tuttavia, sono necessarie ulteriori ricerche per comprendere appieno i suoi meccanismi e il potenziale terapeutico.

Formula: C₁₇H₁₄N₂

InChI: InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2

InChI key: InChIKey=VFTRKSBEFQDZKX-UHFFFAOYSA-N

SMILES: C(C=1C=2C(NC1)=CC=CC2)C=3C=4C(NC3)=CC=CC4

Sinonimi:

• 1H-Indole, 3,3′-methylenebis-
• 3,3'-Methylenebisindole
• 3,3'-methanediylbis(1H-indole)
• 3,3'Diindolemethane
• 3,3-Methylenediindole
• 3,3′-Bisindolylmethane
• 3,3′-Methanediyldi(1H-indole)
• 3,3′-Methylenebis[1H-indole]
• 3-[(1H-Indol-3-yl)methyl]-1H-indole
• Arundine
• Bis(1H-indol-3-yl)methane
• Bis(3-indolyl)methane
• Cervicon-DIM
• DIM
• DIM (AhR agonist)
• DIM (diindolylmethane)
• Di(1H-indol-3-yl)methane
• Diindolylmethane
• Diindoylmethane
• Hb 236
• Indole, 3,3′-methylenedi-
• Infemin
• 3,3-Diindolylmethane

3,3'-Methylenediindole

CAS: 1968-05-4

Formula: C₁₇H₁₄N₂

Purezza: >98.0%(N)

Colore e forma: White to Light yellow to Light red powder to crystal

Peso molecolare: 246.31

Ref: 3B-M1399

3,3'-Diindolylmethane

CAS: 1968-05-4

3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.

Formula: C₁₇H₁₄N₂

Purezza: 99.09%

Colore e forma: Solid

Peso molecolare: 246.3065

Ref: TM-T2991

3,3'-Diindolylmethane

CAS: 1968-05-4

3,3'-Diindolylmethane

Formula: C₁₇H₁₄N₂

Purezza: ≥98%

Peso molecolare: 246.31

Ref: 54-BUP14951

3,3''-Diindolylmethane

CAS: 1968-05-4

Formula: C₁₇H₁₄N₂

Purezza: ≥ 98.0% (anhydrous basis)

Colore e forma: White to off-white crystalline powder

Peso molecolare: 246.31

Ref: 7W-GK6642

3,3-MethylenedIIndole

CAS: 1968-05-4

3,3-MethylenedIIndole

Formula: C₁₇H₁₄N₂

Purezza: >98%

Peso molecolare: 246.31

Ref: 54-OR1010762

3,3'-Bisindolylmethane

CAS: 1968-05-4

Formula: C₁₇H₁₄N₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 246.3065

Ref: IN-DA003BAM

3,3'-Diindolylmethane

Prodotto controllato

CAS: 1968-05-4

Applications 3,3'-Diindolylmethane is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. 3,3'-Diindolylmethane is an antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
References Kandala, et al.: Mol.Pharmacol., 78, 297 (2010), Kandala, et al.: J. Pharmacol. Exp. Ther., 341 24 (2012),

Formula: C₁₇H₁₄N₂

Colore e forma: Neat

Peso molecolare: 246.31

Ref: TR-D455190

Bis (3-indolyl)methane

CAS: 1968-05-4

Formula: C₁₇H₁₄N₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 246.313

Ref: 10-F024220

3,3'-Diindolylmethane

CAS: 1968-05-4

3,3'-Diindolylmethane

Formula: C₁₇H₁₄N₂

Purezza: 98%

Peso molecolare: 246.31

Ref: IN-DG8848

3,3'-Diindolymethane (synthetic)

CAS: 1968-05-4

3,3'-Diindolylmethane, also known as DIM, is natural compound derived from indole. In a recent study, DIM was evaluated as a potential agent for preventing biofilm formation by Streptococcus mutans, which is a major cause of dental caries. The researchers found that DIM significantly inhibited biofilm formation (by 92%) and reduced the production of extracellular polymeric substances (EPS), which are important for biofilm stability particularly under acidic conditions. The study suggests that 3,3'-diindolylmethane has anti-biofilm and anti-virulence properties against S. mutans, and it is a potential candidate for reducing biofilm formation and preventing dental caries.
It has been also reported that 3,3'-diindolymethane can act as a chemopreventive agent. DIM has estrogenic effects without interacting with the binding domain of the estrogen receptors. This study found that DIM could suppress cell growth and disrupt cell cycle progression of young adult mouse colonocytes (YAMCs) in vitro. Moreover, DIM altered gene expression associated with apoptosis and cell proliferation, and it induced transcriptional activity of the estrogen receptor (ER), which was inhibited by an ER antagonist.

Formula: C₁₇H₁₄N₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 246.31 g/mol

Ref: 3D-FD14886

3,3'-Diindolymethane (natural)

CAS: 1968-05-4

3,3'-Diindolylmethane, also known as DIM, is natural compound derived from indole. In a recent study, DIM was evaluated as a potential agent for preventing biofilm formation by Streptococcus mutans, which is a major cause of dental caries. The researchers found that DIM significantly inhibited biofilm formation (by 92%) and reduced the production of extracellular polymeric substances (EPS), which are important for biofilm stability particularly under acidic conditions. The study suggests that 3,3'-diindolylmethane has anti-biofilm and anti-virulence properties against S. mutans, and it is a potential candidate for reducing biofilm formation and preventing dental caries. It has been also reported that 3,3'-diindolymethane can act as a chemopreventive agent. DIM has estrogenic effects without interacting with the binding domain of the estrogen receptors. This study found that DIM could suppress cell growth and disrupt cell cycle progression of young adult mouse colonocytes (YAMCs) in vitro. Moreover, DIM altered gene expression associated with apoptosis and cell proliferation, and it induced transcriptional activity of the estrogen receptor (ER), which was inhibited by an ER antagonist.

Formula: C₁₇H₁₄N₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 246.31 g/mol

Ref: 3D-FD14887