CAS 197922-42-2

Teduglutide

Descrizione:

Teduglutide è un analogo sintetico del peptide simile al glucagone umano-2 (GLP-2), un ormone coinvolto nella regolazione della crescita e della funzione intestinale. È utilizzato principalmente nel trattamento della sindrome dell'intestino corto, una condizione che può insorgere dopo la rimozione chirurgica di una parte significativa dell'intestino. Teduglutide promuove l'assorbimento intestinale di nutrienti e fluidi, migliorando così la qualità della vita dei pazienti con questa condizione. La sostanza viene somministrata tramite iniezione sottocutanea e ha una emivita relativamente lunga grazie alla sua resistenza alla degradazione enzimatica. Il suo meccanismo d'azione implica il legame al recettore del GLP-2, portando a una crescita migliorata della mucosa intestinale, un aumento dell'altezza dei villi e un miglior assorbimento dei nutrienti. Gli effetti collaterali comuni possono includere sintomi gastrointestinali, come nausea e dolore addominale, così come potenziali rischi di neoplasia a causa dei suoi effetti promotori della crescita. In generale, Teduglutide rappresenta un avanzamento significativo nella gestione della sindrome dell'intestino corto, offrendo ai pazienti un miglior stato nutrizionale e una ridotta dipendenza dal supporto parenterale.

Formula: C₁₆₄H₂₅₂N₄₄O₅₅S

InChI: InChI=1S/C164H252N44O55S/c1-21-77(11)126(156(255)187-95(44-46-114(167)214)141(240)206-130(83(17)211)160(259)186-93(42-33-34-49-165)140(239)202-129(80(14)24-4)159(258)208-131(84(18)212)161(260)200-111(163(262)263)66-125(230)231)203-151(250)100(54-76(9)10)189-145(244)103(57-88-67-175-92-41-32-31-40-90(88)92)192-147(246)105(60-116(169)216)199-157(256)127(78(12)22-2)204-152(251)102(56-87-38-29-26-30-39-87)190-149(248)109(64-123(226)227)195-137(236)94(43-35-50-174-164(171)172)183-134(233)82(16)179-133(232)81(15)180-142(241)98(52-74(5)6)188-146(245)104(59-115(168)215)194-150(249)110(65-124(228)229)196-143(242)99(53-75(7)8)198-158(257)128(79(13)23-3)205-162(261)132(85(19)213)207-153(252)106(61-117(170)217)193-139(238)97(48-51-264-20)185-138(237)96(45-47-120(220)221)184-148(247)108(63-122(224)225)197-155(254)113(72-210)201-144(243)101(55-86-36-27-25-28-37-86)191-154(253)112(71-209)182-119(219)70-177-136(235)107(62-121(222)223)181-118(218)69-176-135(234)91(166)58-89-68-173-73-178-89/h25-32,36-41,67-68,73-85,91,93-113,126-132,175,209-213H,21-24,33-35,42-66,69-72,165-166H2,1-20H3,(H2,167,214)(H2,168,215)(H2,169,216)(H2,170,217)(H,173,178)(H,176,234)(H,177,235)(H,179,232)(H,180,241)(H,181,218)(H,182,219)(H,183,233)(H,184,247)(H,185,237)(H,186,259)(H,187,255)(H,188,245)(H,189,244)(H,190,248)(H,191,253)(H,192,246)(H,193,238)(H,194,249)(H,195,236)(H,196,242)(H,197,254)(H,198,257)(H,199,256)(H,200,260)(H,201,243)(H,202,239)(H,203,250)(H,204,251)(H,205,261)(H,206,240)(H,207,252)(H,208,258)(H,220,221)(H,222,223)(H,224,225)(H,226,227)(H,228,229)(H,230,231)(H,262,263)(H4,171,172,174)/t77-,78-,79-,80-,81-,82-,83+,84+,85+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,126-,127-,128-,129-,130-,131-,132-/m0/s1

InChI key: CILIXQOJUNDIDU-ASQIGDHWSA-N

SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CC5=CN=CN5)N

Sinonimi:

• Alx 0600

Teduglutide

CAS: 197922-42-2

Formula: C₁₆₄H₂₅₂N₄₄O₅₅S

Peso molecolare: 3752.13

Ref: 4Z-PT-312001

Teduglutide

CAS: 197922-42-2

Formula: C₁₆₄H₂₅₂N₄₄O₅₅S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 3752.0825

Ref: IN-DA00ACKN

Teduglutide-d8 TFA salt x hydrate (Leu-methyl-d3+Phe-d5)

Prodotto controllato

CAS: 197922-42-2

Applications Teduglutide-d8 TFA salt x hydrate (Leu-methyl-d3+Phe-d5) is an isotopically labelled form of Teduglutide (T013795), which is glucagon-like peptide-2 (GLP-2) analogue that is used for the treatment of short bowel syndrome.
References Jeppesen, P., et al.: Gut, 54, 1224 (2005)
Chemical Name: Jeppesen, P., et al.: Gut, 54, 1224 (2005)

Formula: C₁₆₄H₂₄₄D₈N₄₄O₅₅S•C₂HF₃O₂•x(H₂O)

Colore e forma: Neat

Peso molecolare: 3760.0811

Ref: TR-T013798

Teduglutide

CAS: 197922-42-2

Teduglutide (ALX-0600) is a glucagon-like peptide-2 analog that increases intestinal absorption and can be used in research on short bowel syndrome (SBS).

Formula: C₁₆₄H₂₅₂N₄₄O₅₅S

Purezza: 98.08% - 99.29%

Colore e forma: White Solid

Peso molecolare: 3752.08

Ref: TM-T35337

Teduglutide (GLP2 2G)

CAS: 197922-42-2

Teduglutide is a GLP-2 analogue, in which the alanine at position 2 has been substituted with glycine making the peptide resistant to degradation by dipeptidyl peptidase-4 (DPP-4)- Teduglutide therefore has a longer half-life than GLP-2 (2-3 hours for teduglutide vs 7 min for GLP-2). Teduglutide has high bioavailability after subcutaneous administration, suggesting that teduglutide has enhanced biological activity, relative to native GLP-2.GLP-2 is a gut hormone produced in the enteroendocrine L cells of gastrointestinal tract by the cleavage of the 160-amino-acid proglucagon molecule. GLP-2 is secreted following the ingestion of food and carries out its activities via the GLP-2 G-protein coupled receptors (GLP-2Rs). GLP-2 has a range of roles within the cell, including: anti-inflammatory effects- promoting the expansion of the intestinal mucosa- stimulating intestinal blood flow- inhibiting gastric acid secretion and gastric emptying- increasing intestinal barrier function and enhancing nutrient and fluid absorption.

Formula: C₁₆₄H₂₅₂N₄₄O₅₅S

Colore e forma: Powder

Peso molecolare: 3,749.8 g/mol

Ref: 3D-CRB1000390

Teduglutide

CAS: 197922-42-2

Teduglutide is a Glucagon-like Peptide-2 Analog which has been used in the treatment of Short Bowel Syndrome. It is avaiable in the Trifluoroacetate salt form.
One-Letter Formula: HGDGSFSDEMNTILDNLAARDFINWLIQTKITD

Formula: C₁₆₄H₂₅₂N₄₄O₅₅S

Purezza: Min. 95%

Peso molecolare: 3,752.16 g/mol

Ref: 3D-TED-3880-PI

Teduglutide

CAS: 197922-42-2

Formula: C₁₆₄H₂₅₂N₄₄O₅₅S

Peso molecolare: 3752.1

Ref: BE-RMCP514001

Teduglutide trifluoroacetate

CAS: 197922-42-2

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₁₆₄H₂₅₂N₄₄O₅₅S

Peso molecolare: 3,752.08 g/mol

Ref: 3D-PP50564

Teduglutide

CAS: 197922-42-2

Formula: C₁₆₄H₂₅₂N₄₄O₅₅S

Peso molecolare: 3752.13

Ref: ST-EA-CP-T111000