CAS 203120-17-6

Laninamivir

Descrizione:

Laninamivir è un composto antivirale utilizzato principalmente nel trattamento dell'influenza. Appartiene alla classe degli inibitori della neuraminidasi, che funzionano bloccando l'enzima virale neuraminidasi, impedendo così il rilascio di nuove particelle virali dalle cellule infette e limitando la diffusione del virus nelle vie respiratorie. Laninamivir è caratterizzato dalla sua lunga emivita, che consente una somministrazione meno frequente rispetto ad altri farmaci antivirali. Viene tipicamente somministrato per inalazione, il che facilita la consegna diretta al sito di infezione nei polmoni. Il composto ha dimostrato efficacia contro vari ceppi di influenza, comprese quelle resistenti ad altri agenti antivirali. Inoltre, Laninamivir ha un profilo di sicurezza favorevole, con effetti collaterali comuni che sono lievi e transitori. Le sue uniche proprietà farmacocinetiche e meccanismo d'azione lo rendono un'opzione preziosa nella gestione dell'influenza, in particolare nelle popolazioni ad alto rischio di complicazioni da virus.

Formula: C₁₃H₂₂N₄O₇

InChI: InChI=1S/C13H22N4O7/c1-5(19)16-9-6(17-13(14)15)3-8(12(21)22)24-11(9)10(23-2)7(20)4-18/h3,6-7,9-11,18,20H,4H2,1-2H3,(H,16,19)(H,21,22)(H4,14,15,17)/t6-,7+,9+,10+,11+/m0/s1

InChI key: InChIKey=QNRRHYPPQFELSF-CNYIRLTGSA-N

SMILES: [C@H]([C@@H](CO)O)(OC)[C@]1([C@H](NC(C)=O)[C@@H](NC(=N)N)C=C(C(O)=O)O1)[H]

Sinonimi:

• (4S,5R,6R)-5-Acetamido-4-carbamimidamido-6-((1R,2R)-3-hydroxy-2-methoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid
• (4S,5R,6R)-5-Acetamido-4-guanidino-6-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid
• 203120-17-6
• 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-<span class="text-smallcaps">D</smallcap>-glycero-<smallcap>D</span>-galacto-non-2-enonic acid
• <span class="text-smallcaps">D</smallcap>-glycero-<smallcap>D</span>-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-
• Laninamivir
• R 125489
• D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-
• 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid

(2R,3R,4S)-3-Acetamido-2-((1R,2R)-2,3-Dihydroxy-1-Methoxypropyl)-4-Guanidino-3,4-Dihydro-2H-Pyran-6-Carboxylic Acid

CAS: 203120-17-6

(2R,3R,4S)-3-Acetamido-2-((1R,2R)-2,3-Dihydroxy-1-Methoxypropyl)-4-Guanidino-3,4-Dihydro-2H-Pyran-6-Carboxylic Acid

Formula: C₁₃H₂₂N₄O₇

Purezza: 98%

Peso molecolare: 346.34

Ref: 54-OR1024357

Laninamivir

CAS: 203120-17-6

Laninamivir (R 125489) inhibits influenza NA (IC50: 0.90-3.12 nM) across strains H12N5, pH1N1, and H2N2.

Formula: C₁₃H₂₂N₄O₇

Purezza: 99%

Colore e forma: White Solid

Peso molecolare: 346.3364

Ref: TM-T15707

Laninamivir

CAS: 203120-17-6

Laninamivir

Formula: C₁₃H₂₂N₄O₇

Purezza: ≥98%

Peso molecolare: 346.34

Ref: 54-BUP02004

(2R,3R,4S)-3-Acetamido-2-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-4-guanidino-3,4-dihydro-2H-pyran-6-carboxylic acid

CAS: 203120-17-6

Formula: C₁₃H₂₂N₄O₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 346.3364

Ref: IN-DA0028OB

Laninamivir

CAS: 203120-17-6

Applications A new potent neuraminidase (NA) inhibitor, shows long-acting anti-influenza virus activity.
References Bantia, S., et al.: Antimicrob. Agents Chemother., 42, 801 (1998), Honda, T., et al.: Bioorg. Med. Chem. Lett., 12, 1925 (2002), Kiso, M., et al.: Lancet, 364, 759 (2004), Macdonald, S., et al.: J. Med. Chem., 48, 2964 (2005),

Formula: C₁₃H₂₂N₄O₇

Colore e forma: Neat

Peso molecolare: 346.34

Ref: TR-L174000

Laninamivir

CAS: 203120-17-6

Formula: C₁₃H₂₂N₄O₇

Peso molecolare: 346.34

Ref: 4Z-L-222001

Laninamivir

CAS: 203120-17-6

(2R,3R,4S)-3-Acetamido-2-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-4-guanidino-3,4-dihydro-2H-pyran-6-carboxylic acid

Formula: C₁₃H₂₂N₄O₇

Purezza: 98%

Peso molecolare: 346.34

Ref: IN-DG318102

Laninamivir

CAS: 203120-17-6

Formula: C₁₃H₂₂N₄O₇

Peso molecolare: 346.34

Ref: BE-RMCL019000

(2R,3R,4S)-3-Acetamido-2-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-4-guanidino-3,4-dihydro-2H-pyran-6-carboxylic acid

CAS: 203120-17-6

Formula: C₁₃H₂₂N₄O₇

Purezza: 98%

Peso molecolare: 346.34

Ref: 10-F549638

Laninamivir-13C,15N2

Prodotto controllato

CAS: 203120-17-6

Applications Isotope labelled Laninamir (L174000) is a new potent neuraminidase (NA) inhibitor, shows long-acting anti-influenza virus activity.
References Bantia, S., et al.: Antimicrob. Agents Chemother., 42, 801 (1998), Honda, T., et al.: Bioorg. Med. Chem. Lett., 12, 1925 (2002), Kiso, M., et al.: Lancet, 364, 759 (2004), Macdonald, S., et al.: J. Med. Chem., 48, 2964 (2005),

Formula: CC₁₂H₂₂₁₅N₂N₂O₇

Colore e forma: Neat

Peso molecolare: 346.34

Ref: TR-L174003

Laninamivir

CAS: 203120-17-6

Laninamivir is an antiviral drug that inhibits the neuraminidase activity of influenza A and B viruses. It is a prodrug that is activated by esterases to form the active metabolite laninamivir carboxylate, which inhibits virus replication. Laninamivir has been shown to be effective against oseltamivir-resistant mutants and has been used in combination with oseltamivir as a treatment for pandemic influenza. Laninamivir has also been studied in pediatric patients with influenza-like symptoms, with significant reductions in symptom severity, duration of symptoms, and viral load.

Formula: C₁₃H₂₂N₄O₇

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 346.34 g/mol

Ref: 3D-ML58733

Laninamivir

CAS: 203120-17-6

Formula: C₁₃H₂₂N₄O₇

Peso molecolare: 346.34

Ref: ST-EA-CP-L83000