CAS 205640-91-1

Oressina B (umana)

Descrizione:

L'orexina B, nota anche come ipocretina-2, è un neuropeptide che gioca un ruolo cruciale nella regolazione dell'eccitazione, della vigilanza e dell'appetito negli esseri umani. Viene prodotta nell'ipotalamo ed è parte del sistema orexina, che include orexina A e orexina B. L'orexina B è caratterizzata dalla sua specifica sequenza di amminoacidi e struttura, che le consente di legarsi ai recettori dell'orexina (OX1R e OX2R) nel cervello, influenzando vari processi fisiologici. Questo peptide è coinvolto nella modulazione dell'equilibrio energetico ed è stato implicato nei disturbi del sonno, in particolare nella narcolessia. L'attività biologica dell'orexina B è influenzata dalla sua stabilità e dalle interazioni con altri neuropeptidi e neurotrasmettitori. Il numero CAS 205640-91-1 identifica in modo univoco questo composto, facilitando il suo riconoscimento nella letteratura scientifica e nelle banche dati. In generale, l'orexina B è un attore significativo nella neurobiologia, con potenziali implicazioni per interventi terapeutici in disturbi legati al sonno e metabolici.

Formula: C₁₂₃H₂₁₂N₄₄O₃₅S

InChI: InChI=1S/C123H212N44O35S/c1-18-63(12)96(118(200)161-80(46-62(10)11)116(198)165-97(67(16)170)119(201)152-70(98(129)180)35-41-203-17)164-94(178)53-140-99(181)64(13)146-100(182)65(14)148-110(192)81(47-68-49-136-57-145-68)160-115(197)82(48-90(128)174)151-92(176)51-142-104(186)83(55-168)162-101(183)66(15)147-106(188)74(30-33-88(126)172)155-113(195)78(44-60(6)7)159-114(196)79(45-61(8)9)158-108(190)72(26-21-38-139-123(134)135)153-109(191)75(31-34-89(127)173)156-112(194)77(43-59(4)5)157-107(189)71(25-20-37-138-122(132)133)149-91(175)50-141-103(185)73(29-32-87(125)171)154-111(193)76(42-58(2)3)150-93(177)52-143-117(199)85-27-22-40-167(85)120(202)86-28-23-39-166(86)95(179)54-144-105(187)84(56-169)163-102(184)69(124)24-19-36-137-121(130)131/h49,57-67,69-86,96-97,168-170H,18-48,50-56,124H2,1-17H3,(H2,125,171)(H2,126,172)(H2,127,173)(H2,128,174)(H2,129,180)(H,136,145)(H,140,181)(H,141,185)(H,142,186)(H,143,199)(H,144,187)(H,146,182)(H,147,188)(H,148,192)(H,149,175)(H,150,177)(H,151,176)(H,152,201)(H,153,191)(H,154,193)(H,155,195)(H,156,194)(H,157,189)(H,158,190)(H,159,196)(H,160,197)(H,161,200)(H,162,183)(H,163,184)(H,164,178)(H,165,198)(H4,130,131,137)(H4,132,133,138)(H4,134,135,139)/t63-,64-,65-,66-,67+,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,96-,97-/m0/s1

InChI key: DHBREICAXZPFDD-WMQZXSDYSA-N

SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)N

Sinonimi:

• L-Methioninamide,L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leu
• H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
• Orexin B(human)
• Hypocretin-2 (huMan)
• L-Methioninamide, L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-
• Orexin B (human), ≥98% (HPLC)
• REF DUPL: Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
• Orexin B (human) (trifluoroacetate salt)
• OREXIN B HUMAN ≥98%
• RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2
• OREXIN B (HUMAN) USP/EP/BP
• HYPOCRETIN-2, HUMAN
• PubChem ID: 90479794
• OREXINS OREXIN B HUMAN
• Human orexin B
• ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2

Orexin B (human)

CAS: 205640-91-1

Like orexin A, orexin B (OXB) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of OXB to rats stimulated food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX₁ receptor is significantly lower (IC₅₀ = 240 nM) than that of orexin A. Binding affinities for the OX₂ receptor are similar for orexin A and B (IC₅₀ = 38 nM and 36 nM, respectively, for displacement of radiolabeled orexin A bound to the receptor).

Formula: C₁₂₃H₂₁₂N₄₄O₃₅S

Purezza: 96.3%

Colore e forma: White

Peso molecolare: 2899.38

Ref: 01-4028263

Orexin B, human

CAS: 205640-91-1

Orexin B, human agonizes Orexin receptors (OX1 Ki=420 nM, OX2 Ki=36 nM), promotes feeding in rats, and is a neuropeptide.

Formula: C₁₂₃H₂₁₂N₄₄O₃₅S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 2899.34

Ref: TM-TP1139

Orexin-B, human TFA salt form

CAS: 205640-91-1

Formula: C₁₂₅H₂₁₃F₃N₄₄O₃₇S

Purezza: 98%

Peso molecolare: 3013.3615

Ref: IN-DA01EAOA

Orexin B (human)

CAS: 205640-91-1

Orexin B (human)

Colore e forma: Solid

Ref: 54-BIBA1033

Orexin B(Human)(Leu* U-13C6,15N)

CAS: 205640-91-1

Formula: C₁₂₃H₂₁₂N₄₄O₃₅S

Peso molecolare: 2899.3

Ref: BE-MCN-10-0009

Orexin B, human TFA

CAS: 205640-91-1

Formula: C₁₂₃H₂₁₂N₄₄O₃₅S

Peso molecolare: 2899.3

Ref: BE-MU-10-0009

Orexin-B (Human)

CAS: 205640-91-1

Orexin B, also known as hypocretin-2, is a neuropeptide that is produced by a small group of neurons in the hypothalamus, a region of the brain that plays a critical role in regulating various physiological functions, including sleep, appetite, and energy balance. Orexin B plays a role in promoting wakefulness and arousal and studies have shown that disruptions in the orexin system are associated with various sleep disorders, including narcolepsy and insomnia. In addition, orexin B has been shown to be involved in the regulation of appetite and energy metabolism, and is being explored as a potential target for the treatment of obesity and other metabolic disorders. Therefore, orexin B is an important neuropeptide and is an active area of research in neuroscience and medicine. This product is available as a 0.1mg vial

Formula: C₁₂₃H₂₁₂N₄₄O₃₅S

Purezza: Min. 95%

Peso molecolare: 2,899.3 g/mol

Ref: 3D-POR-4348-S

Orexin B (human) trifluoroacetate salt

CAS: 205640-91-1

Orexin B (human) trifluoroacetate salt H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln -Ala -Ser -Gly -Asn -His -Ala -Ala -Gly -Ile -Leu -Thr
Met –NH2 trifluoroacetate salt is an amino acid sequence that is found in the human body. It is a polypeptide that regulates arousal, wakefulness, and appetite. Orexin B (human) trifluoroacetate salt H Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu Gln Arg Leu Leu Gln Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met NH2 trifluoroacetate salt promotes apoptosis by binding to c

Formula: C₁₂₃H₂₁₂N₄₄O₃₅S

Purezza: Min. 95%

Peso molecolare: 2,899.34 g/mol

Ref: 3D-FO109202