CAS 209410-46-8

5-(2,6-diclorofenile)-2-[(2,4-difluorofenile)tio]-6H-pirimido[1,6-b]piridazin-6-one

Descrizione:

5-(2,6-diclorofenile)-2-[(2,4-difluorofenile)tio]-6H-pirimido[1,6-b]piridazin-6-one, con il numero CAS 209410-46-8, è un composto organico sintetico caratterizzato dalla sua complessa struttura eterociclica. Questo composto presenta un nucleo di pirimidina e piridazina, che contribuisce alla sua potenziale attività biologica. La presenza di gruppi diclorofenile e difluorofenile indica una significativa alogenazione, che può migliorare la lipofilia e influenzare l'interazione del composto con obiettivi biologici. Il legame tioetere introduce zolfo nella struttura, potenzialmente influenzando la sua reattività e solubilità. Questo composto può mostrare proprietà farmacologiche, rendendolo di interesse nella chimica medicinale, in particolare nello sviluppo di nuovi agenti terapeutici. Le sue caratteristiche specifiche, come il punto di fusione, la solubilità e i dati spettroscopici, sarebbero tipicamente determinate attraverso metodi sperimentali. In generale, le caratteristiche strutturali uniche di questo composto suggeriscono che potrebbe svolgere un ruolo in varie applicazioni chimiche e biologiche.

Formula: C₁₉H₉Cl₂F₂N₃OS

InChI: InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H

InChI key: InChIKey=VEPKQEUBKLEPRA-UHFFFAOYSA-N

SMILES: O=C1C(=C2N(N=C(SC3=C(F)C=C(F)C=C3)C=C2)C=N1)C4=C(Cl)C=CC=C4Cl

Sinonimi:

• 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one
• 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one
• 6H-Pyrimido[1,6-b]pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-
• Neflamapimod
• Vd 31745
• Vrt 031745
• Vx-745
• 5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

Neflamapimod

CAS: 209410-46-8

Neflamapimod

Formula: C₁₉H₉Cl₂F₂N₃OS

Purezza: ≥95%

Peso molecolare: 436.26

Ref: 54-BUP10374

VX-745

CAS: 209410-46-8

VX-745

Formula: C₁₉H₉Cl₂F₂N₃OS

Purezza: 99.8% (Typical Value in Batch COA)

Colore e forma: Solid

Peso molecolare: 436.26206

Ref: 54-BISN0180

5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

CAS: 209410-46-8

Formula: C₁₉H₉Cl₂F₂N₃OS

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 436.2621

Ref: IN-DA002K7Y

VX-745

CAS: 209410-46-8

Ref: 7W-GW2962

Neflamapimod

CAS: 209410-46-8

Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.

Formula: C₁₉H₉Cl₂F₂N₃OS

Purezza: 97.88% - 99.75%

Colore e forma: Yellow Solid

Peso molecolare: 436.26

Ref: TM-T6089

Neflamapimod

CAS: 209410-46-8

5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one

Formula: C₁₉H₉Cl₂F₂N₃OS

Purezza: 98%

Peso molecolare: 436.26

Ref: IN-DG41447

5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one

CAS: 209410-46-8

Formula: C₁₉H₉Cl₂F₂N₃OS

Purezza: 98%

Peso molecolare: 436.26

Ref: 10-F092709

VX 745

Prodotto controllato

CAS: 209410-46-8

Applications VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.
References Haddad, J.J.: Curr. Opin. Invest. Drugs, 2, 1070 (2001); Duffy, J.P. et al.: ACS Med. Chem. Lett., 2, 758 (2011); Bagley, M.C. et al.: Pharmaceuticals, 3, 1842 (2010);

Formula: C₁₉H₉Cl₂F₂N₃OS

Colore e forma: Neat

Peso molecolare: 436.26

Ref: TR-V900500

Neflamapimod

CAS: 209410-46-8

5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one (NVP-BEZ235) is a molecule that inhibits the activity of the phosphoinositide 3 kinase (PI3K) pathway. This pathway regulates cell growth and survival by controlling cellular energy production and distribution. The PI3K pathway is active in a number of cancers, including colorectal cancer and acute myeloid leukemia. NVP-BEZ235 has been shown to be effective for treating bowel disease and inflammatory bowel disease in clinical trials. In addition, it is also an effective treatment for cancer with platinum based chemotherapy. The most common side effects are nausea, vomiting, diarrhea, constipation, anorexia, fatigue and headache.

Formula: C₁₉H₉Cl₂F₂N₃OS

Purezza: Min. 95%

Peso molecolare: 436.26 g/mol

Ref: 3D-FD139233