CAS 211914-51-1

Dabigatran

Descrizione:

Dabigatran è un farmaco anticoagulante orale utilizzato principalmente per la prevenzione e il trattamento dei disturbi tromboembolici, come la fibrillazione atriale e la trombosi venosa profonda. Funziona come un inibitore diretto della trombina, il che significa che inibisce direttamente l'attività della trombina, un enzima cruciale per la formazione di coaguli di sangue. La formula chimica di Dabigatran è C19H21N7O5S e presenta una struttura unica che include un gruppo acido carbossilico, un gruppo amminico e un moiety sulfonamide. Dabigatran è caratterizzato dalla sua alta biodisponibilità e dal rapido inizio d'azione, rendendolo efficace per la gestione dei disturbi della coagulazione. Viene tipicamente somministrato come un pro-farmaco, Dabigatran etexilato, che viene convertito nella sua forma attiva nel corpo. La sostanza è nota per la sua farmacocinetica prevedibile, che consente una dosaggio fisso senza la necessità di monitoraggio routinario dei livelli di anticoagulazione, a differenza degli anticoagulanti tradizionali come la warfarina. Tuttavia, è essenziale considerare i potenziali effetti collaterali, inclusi i rischi di sanguinamento, e utilizzarlo sotto supervisione medica.

Formula: C₂₅H₂₅N₇O₃

InChI: InChI=1/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)

InChI key: InChIKey=YBSJFWOBGCMAKL-UHFFFAOYSA-N

SMILES: CN1C=2C(=CC(C(N(CCC(O)=O)C3=CC=CC=N3)=O)=CC2)N=C1CNC4=CC=C(C(=N)N)C=C4

Sinonimi:

• 3-[[2-[[(4-Carbamimidoylphenyl)Amino]Methyl]-1-Methyl-Benzoimidazole-5-Carbonyl]-Pyridin-2-Yl-Amino]Propanoic Acid
• Bibr 953
• Bibr 953Zw
• Dabigatran
• N-(2-(4-(N-(Hexyloxycarbonyl)Amidino)Phenylaminomethyl)-1-Methyl-1H-Benzimidazol-5-Ylcarbonyl)-N-(2-Pyridyl)-Beta-Alanine Ethyl Ester
• N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine
• beta-alanine, N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-
• β-Alanine, N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-
• N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-ben...
• N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine
• Dabiga group
• BIBR953;BIBR 953;BIBR-953
• Dabigatran etexilate impurity1513
• 3-[[2-[[(4-carbaMiMidoylphenyl)aMino]Methyl]-1-Met
• BIBR 953 (Dabigatran, Pradaxa)
• Dabigatran(BIB-953
• Dabigatran Q: What is the CAS Number of
• BIB-953
• 3-(2-((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid
• BIBR 953(Dabigatran)
• Dabigatran Etexilate Mesilate
• Dabigatran etexilate-1
• Dabigatran base
• 3-[[2-[[(4-carbaMiMidoylphenyl)aMino]Methyl]-1-Methyl-benzoiMidazole-5-carbonyl]-pyridin-2-yl-aMino]
• 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic
• Dabigatran3-(2-((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid
• Dabigatran Ester Impurity B
• Dabigatran API
• BIBR 953;BIBR 953ZW;BIBR953;BIB-953
• Dabigatran Impurity U
• 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid
• 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid Dabigatran (BIBR 953)
• Dabigatran (Acid)
• ethyl 3-(2-(((4-(N'-((hexan-2-yloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
• N-[[2-[[[4-(AMinoiMinoMethyl)phenyl]aMino]Methyl]-1-Methyl-1H-benzo[d]iMidazol-5-yl]carbonyl]-N-pyridin-2-yl-beta-alanine
• DabigatranQ: What is
• Dabigatran (BIBR 953)
• Dabigatran etexilate impurity189
• Dabigatran Impurity b
• N- (2-{ (4-carbaMiMidoylphenyl)aMino Methyl}-1-Met
• Dabigatran Q: What are the applications of
• Dabigatran Q: What is the storage condition of
• Dabigatran USP/EP/BP
• CS-1864
• N-[(2-{[(4-carbaMiMidoylphenyl)aMino]Methyl}-1-Methyl-1HbenziMidazol-

3-[1-(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-1,3-benzodiazol-5-yl)-N-(pyridin-2-yl)formamido]propanoic acid

CAS: 211914-51-1

Formula: C₂₅H₂₅N₇O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 471.5111

Ref: IN-DA00I41W

3-(2-(((4-Carbamimidoylphenyl)Amino)Methyl)-1-Methyl-N-(Pyridin-2-Yl)-1H-Benzo[D]Imidazole-5-Carboxamido)Propanoic Acid

CAS: 211914-51-1

3-(2-(((4-Carbamimidoylphenyl)Amino)Methyl)-1-Methyl-N-(Pyridin-2-Yl)-1H-Benzo[D]Imidazole-5-Carboxamido)Propanoic Acid

Purezza: 98%

Peso molecolare: 471.51g/mol

Ref: 54-OR1010625

Dabigatran

CAS: 211914-51-1

Formula: C₂₅H₂₅N₇O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 471.52

Ref: 4Z-D-591

Dabigatran-13C-d3

CAS: 211914-51-1

Formula: C₂₄₁₃CH₂₂D₃N₇O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 475.53

Ref: 4Z-D-59109

Dabigatran

CAS: 211914-51-1

Dabigatran

Purezza: ≥95%

Peso molecolare: 471.51g/mol

Ref: 54-BUP05533

N-Nitroso Dabigatran Etexilate-13C-d3

CAS: 211914-51-1

Formula: C₃₃₁₃CH₃₇D₃N₈O₆

Colore e forma: White To Off-White Solid

Peso molecolare: 660.75

Ref: 4Z-D-59138

Dabigatran

CAS: 211914-51-1

Formula: C₂₅H₂₅N₇O₃

Purezza: >95.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 471.52

Ref: 3B-D5902

Dabigatran

CAS: 211914-51-1

Colore e forma: Neat

Ref: 86-MM3522.02

Dabigatran

CAS: 211914-51-1

Dabigatran (BIBR 953ZW), a thrombin inhibitor, prevents thrombus formation, reducing stroke and embolism risk in nonvalvular atrial fibrillation patients.

Formula: C₂₅H₂₅N₇O₃

Purezza: 97.44% - 98.7%

Colore e forma: Tan Solid

Peso molecolare: 471.51

Ref: TM-T6295

Dabigatran

CAS: 211914-51-1

Applications Nonpeptide, direct thrombin inhibitor. Antithrombotic.
References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002), Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002), Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),

Formula: C₂₅H₂₅N₇O₃

Colore e forma: Neat

Peso molecolare: 471.51

Ref: TR-D100090

Dabigatran-d7 (>90%)

Prodotto controllato

CAS: 211914-51-1

Applications Dabigatran-d7, is the labeled analogue of Dabigatran (D100090), Nonpeptide, direct thrombin inhibitor. Antithrombotic.
References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002), Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002), Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),

Formula: C₂₅H₁₈D₇N₇O₃

Colore e forma: Neat

Peso molecolare: 478.55

Ref: TR-D100093

Dabigatran

CAS: 211914-51-1

Formula: C₂₅H₂₅N₇O₃

Peso molecolare: 471.51

Ref: ST-EA-CP-D5003

Dabigatran

CAS: 211914-51-1

Dabigatran is an oral prodrug that is converted to dabigatran etexilate by esterases in the blood. Dabigatran etexilate is an anticoagulant that inhibits thrombin formation and also prevents the conversion of fibrinogen to fibrin. The drug is used for the prevention of stroke or embolism in people with atrial fibrillation, as well as treatment and prevention of deep venous thrombosis and pulmonary embolism. Dabigatran etexilate has a long half-life of 15-20 hours, meaning that it can be administered once daily. There are two analytical methods for measuring dabigatran concentrations in plasma: one based on the activity of the drug's main metabolite (dabigatran etexilate) and another based on both dabigatran and its active metabolite (dabigatran etexil

Formula: C₂₅H₂₅N₇O₃

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 471.51 g/mol

Ref: 3D-FD32710

DABIGATRAN

CAS: 211914-51-1

Purezza: 98%

Peso molecolare: 471.5209961

Ref: 10-F799805