CAS 23720-80-1
:Nardosinone
Descrizione:
Nardosinone è un composto sesquiterpenico naturale derivato principalmente dalla pianta Nardostachys jatamansi, comunemente nota come spikenard. È caratterizzato dalla sua complessa struttura biciclica, che contribuisce alle sue uniche proprietà chimiche. Nardosinone mostra una gamma di attività biologiche, inclusi effetti antinfiammatori, antimicrobici e potenziali effetti neuroprotettivi, rendendolo di interesse nella ricerca farmacologica. Il composto si trova tipicamente in oli essenziali ed estratti della pianta, e la sua presenza è spesso associata a pratiche medicinali tradizionali. In termini di solubilità, Nardosinone è generalmente più solubile nei solventi organici che in acqua, il che è comune per molti terpenoidi. La sua struttura molecolare include più gruppi funzionali che possono partecipare a varie reazioni chimiche, migliorando le sue potenziali applicazioni sia nella chimica dei prodotti naturali che nello sviluppo terapeutico. In generale, Nardosinone rappresenta un composto significativo nel campo dei prodotti naturali, con studi in corso volti a chiarire il suo ampio spettro di effetti biologici e potenziali usi in medicina.
Formula:C15H22O3
InChI:InChI=1S/C15H22O3/c1-9-6-5-7-10-11(16)8-12-13(15(9,10)4)14(2,3)18-17-12/h7,9,12-13H,5-6,8H2,1-4H3/t9-,12-,13+,15+/m1/s1
InChI key:InChIKey=KXGHHSIMRWPVQM-JWFUOXDNSA-N
SMILES:C[C@@]12[C@]3([C@@](CC(=O)C1=CCC[C@H]2C)(OOC3(C)C)[H])[H]
Sinonimi:- (3aR,9R,9aR,9bS)-1,1,9,9a-tetramethyl-1,3a,4,7,8,9,9a,9b-octahydro-5H-naphtho[2,1-c][1,2]dioxol-5-one
- (3aR,9R,9aR,9bS)-1,3a,4,7,8,9,9a,9b-Octahydro-1,1,9,9a-tetramethyl-5H-naphtho[2,1-c][1,2]dioxol-5-one
- 5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)-
- 5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, [3aR-(3aα,9α,9aα,9bα)]-
- Nardosinon
- Nardosinone
Filtra per
Percentuale di purezza
0
100
|
0
|
50
|
90
|
95
|
100
Trovati 13 prodotti.
- Prezzo più basso
- Prezzo più alto
- Purezza più bassa
- Purezza più alta
- Consegna più veloce
(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-3a,4,7,8,9,9a-hexahydro-1H-naphtho[2,1-c][1,2]dioxol-5(9bH)-one
CAS:Formula:C15H22O3Purezza:99%Colore e forma:SolidPeso molecolare:250.3334Nardosinone
CAS:Nardosinone is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities. It has a wide spectrum of targets including PI3K,Akt,MEK,ERK, PKA, MAPK.Formula:C15H22O3Purezza:95%~99%Peso molecolare:250.338Nardosinone (Standard)
CAS:Nardosinone (Standard) is a reference standard for research and analysis in studies involving Nardosinone. 1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed to OGD, which may be relevant to the promotion of PKA and ERK signaling pathway. 3. Nardosinone enhances staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying both the MAP kinase-dependent and -independent signaling pathways of dbcAMP and staurosporine. 4. The enhancement of NGF-induced neurite outgrowth from PC12D cells by Nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of NGF coupled with PKC.Formula:C15H22O3Peso molecolare:250.3334Nardosinone
CAS:Prodotto controllatoApplications Nardosinone reduces neuronal injury and protects H9c2 cardiac cells from angiotensin II-induced hypertrophy which may give rise to heart failure. Enhancer of nerve growth factor (NGF).
References Du, M. et al.: J. Huazhong Uni. Sci. Tech. Med. Serv., 33, 822 (2013); Li, P. et al.: Dev. Brain Res., 145, 177 (2003);Formula:C15H22O3Colore e forma:NeatPeso molecolare:250.33(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-3a,4,7,8,9,9a-hexahydro-1H-naphtho[2,1-c][1,2]dioxol-5(9bH)-one
CAS:Formula:C15H22O3Purezza:99%Peso molecolare:250.33Nardosinone
CAS:Nardosinone inhibits H9c2 cell hypertrophy, protects neurons from OGD, and boosts neurite outgrowth by modifying key signaling pathways.Formula:C15H22O3Purezza:98.82% - 99%Colore e forma:SolidPeso molecolare:250.3334Nardosinone
CAS:Oxygen-heterocyclic compoundFormula:C15H22O3Purezza:≥ 98.0 % (HPLC)Colore e forma:CrystalsPeso molecolare:250.34Nardosinone
CAS:Prodotto controllatoNardosinone is a secoiridoid compound, which is a natural product derived from the roots of the plant Nardostachys jatamansi, commonly known as spikenard. The source of Nardosinone is a flowering plant that is native to the Himalayan region and has been traditionally used in Ayurvedic medicine for its therapeutic properties. The mode of action of Nardosinone involves modulation of neurotransmitter systems, inhibition of neuroinflammation, and protection against oxidative damage, contributing to its neuroprotective effects. Nardosinone exhibits potential applications in the treatment of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, due to its ability to improve cognitive function and mitigate neuronal damage. Additionally, it is being investigated for its potential role in mood regulation and anti-anxiety effects. Given its intriguing pharmacological profile, Nardosinone is the subject of ongoing research aimed at understanding its comprehensive mechanisms and potential therapeutic benefits in neuroscience.Formula:C15H22O3Purezza:Min. 95%Colore e forma:SolidPeso molecolare:250.33 g/mol
![(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-3a,4,7,8,9,9a-hexahydro-1H-naphtho[2,1-c][1,2]dioxol-5(9bH)-…](https://static.cymitquimica.com/products/IN/thumb/DA00C4G3.jpg)
