CAS 2375840-87-0
:6-Chloro-4-fluoropyridine-3-boronic acid
CAS:Formula:C20H14ClF2NO5SPurezza:98%Colore e forma:SolidPeso molecolare:453.8437Methyl 3-Chloro-5-(N-(4,6-Difluoro-[1,1'-Biphenyl]-3-Yl)Sulfamoyl)-4-Hydroxybenzoate
CAS:Methyl 3-Chloro-5-(N-(4,6-Difluoro-[1,1'-Biphenyl]-3-Yl)Sulfamoyl)-4-HydroxybenzoateFormula:C20H14ClF2NO5SPurezza:98%Peso molecolare:453.84NDI-091143
CAS:NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate bindingFormula:C20H14ClF2NO5SPurezza:97.03% - ≥95%Colore e forma:SolidPeso molecolare:453.84Methyl 3-chloro-5-(N-(4,6-difluoro-[1,1′-biphenyl]-3-yl)sulfamoyl)-4-hydroxybenzoate
CAS:Formula:C20H14ClF2NO5SPurezza:98%Peso molecolare:453.84NDI-091143
CAS:NDI-091143 is a drug that inhibits prenylation, which is the process whereby proteins are modified by the attachment of a chain of seven carbon atoms called an isoprenoid. This process is important for cancer cell survival and the maintenance of healthy cells. Inhibiting this process leads to apoptosis, or cell death, in cancer cells. NDI-091143 has been shown to have potent inhibition against acetylated proteins in vitro. The drug has also been shown to be hydrophobic and druggable, meaning it can cross the blood brain barrier and enter cells. Additionally, NDI-091143 has been found to bind to cavity surfaces in cryo-electron microscopy studies. The drug inhibits cancer cell growth by binding to a specific site on HMG CoA reductase which results in reduced levels of cholesterol synthesis.
NDI-091143's mechanism of action involves inhibiting the enzyme 3β-hydroxysterFormula:C20H14ClF2NO5SPurezza:Min. 95%Peso molecolare:453.84 g/mol
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