CAS 2407451-82-3

3-Pyridinecarboxamide, 5-fluoro-2-methoxy-N-[6-[4-[(1S)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

Formula: C₁₇H₁₄F₄N₆O₂

InChI: InChI=1S/C17H14F4N6O2/c1-9(17(19,20)21)27-8-23-26-14(27)12-4-3-5-13(24-12)25-15(28)11-6-10(18)7-22-16(11)29-2/h3-9H,1-2H3,(H,24,25,28)/t9-/m0/s1

InChI key: MXOCTLMVBIGSKH-VIFPVBQESA-N

SMILES: C[C@@H](C(F)(F)F)N1C=NN=C1C2=NC(=CC=C2)NC(=O)C3=C(N=CC(=C3)F)OC

Sinonimi:

• 3-Pyridinecarboxamide, 5-fluoro-2-methoxy-N-[6-[4-[(1S)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

ASK1-IN-6

CAS: 2407451-82-3

ASK1-IN-6 (Compound 32), a selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor, exhibits an IC50 of 25 nM. This compound readily crosses the blood-brain barrier, as evidenced by rat pharmacokinetics showing a clearance/unchanged clearance rate of 1.6/56 L/h/kg and an unbound partition coefficient (Kp,uu) of 0.46. Additionally, ASK1-IN-6 demonstrates anti-inflammatory activity and effectively improves symptoms in the Alzheimer's Disease Tg4510 mouse model.

Formula: C₁₇H₁₄F₄N₆O₂

Colore e forma: Solid

Peso molecolare: 410.33

Ref: TM-T88037