CAS 25126-32-3

(27-tir(so(3)H))colecistochinina-frammento (26-33)-amide

Descrizione:

La sostanza chimica nota come "(27-tir(so(3)H))colecistochinina-frammento (26-33)-amide," con il numero CAS 25126-32-3, è un frammento peptidico derivato dalla colecistochinina (CCK), un ormone coinvolto nella digestione e nella sazietà. Questo specifico frammento è composto da aminoacidi dal 26 al 33 della molecola di CCK, con una tirosina solfatata in posizione 27, che è cruciale per la sua attività biologica. La presenza del gruppo solfato migliora l'interazione del peptide con i suoi recettori, influenzando vari processi fisiologici come la contrazione della cistifellea e la secrezione di enzimi dal pancreas. La struttura di questo peptide include una sequenza di aminoacidi legati da legami peptidici e presenta proprietà tipiche dei peptidi, come la solubilità in acqua e la stabilità in condizioni fisiologiche. La sua importanza biologica è sottolineata dal suo ruolo nel sistema gastrointestinale, rendendolo un argomento di interesse negli studi relativi alla digestione, alla regolazione dell'appetito e alle potenziali applicazioni terapeutiche nei disturbi gastrointestinali.

Formula: C₄₉H₆₂N₁₀O₁₆S₃

InChI: InChI=1/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1

InChI key: IZTQOLKUZKXIRV-YRVFCXMDSA-N

SMILES: CSCC[C@@H](C(=NCC(=N[C@@H](Cc1c[nH]c2ccccc12)C(=N[C@@H](CCSC)C(=N[C@@H](CC(=O)O)C(=N[C@@H](Cc1ccccc1)C(=N)O)O)O)O)O)O)N=C([C@H](Cc1ccc(cc1)OS(=O)(=O)O)N=C([C@H](CC(=O)O)N)O)O

Sinonimi:

• (tyr(so3H)27)-cholecystokinin fragment*26-33 amid
• Sincalide
• Cholecystokinin Octapeptide
• Tyr(SO3H]27)Cholecystokinin fragment 26-33 Amide
• alpha-aspartyl-O-sulfotyrosylmethionylglycyltryptophylmethionyl-alpha-aspartylphenylalaninamide
• L-alpha-aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide
• Sincalide(CCK-8)
• Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
• Caerulein, 1-de(5-oxo-L-proline)-2-de-L-glutamine-5-L-methionine-
• Cholecystokinin C-terminal octapeptide
• Cholecystokinin octapeptide (26-33 sulfated)
• Cholecystokinin-(26-33)-amide
• Cholecystokinin-8 (chicken)
• Cholecystokinin-8 (pig)
• Cholecystokinin-8 (Squalus acanthias)
• Cholecystokinin-8 (swine)
• Cholecystokinin-pancreozymin (swine intestine C-terminal octapeptide)
• Cholecystokinin-pancreozymin C-terminal octapeptide
• Human CCK-8
• L-Phenylalaninamide, L-α-aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
• Sincalid
• Sincalida

Cholecystokinin, CCK Octapeptide (26-33)

CAS: 25126-32-3

For cellular and molecular biology applications

Colore e forma: White, Lyophilized Powder

Ref: 02-J66669

Cholecystokinin Octapeptide (sulfated)

CAS: 25126-32-3

CCK-8 exhibits various gastrointestinal effects as contraction of the gallbladder and stimulation of pancreatic secretion and gastrointestinal transit. In rats, CCK-8 facilitated the uptake of leptin from peripheral circulation to cerebrospinal fluid and its access to the hypothalamus.

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purezza: 98.42%

Colore e forma: White Powder

Peso molecolare: 1143.29

Ref: 01-4033010

Sincalide

CAS: 25126-32-3

Sincalide

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Colore e forma: Solid-Powder

Peso molecolare: 1143.26898

Ref: 54-BITH3042

Sincalide

CAS: 25126-32-3

Sincalide

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purezza: ≥98%

Peso molecolare: 1143.27

Ref: 54-BUP02057

(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide

CAS: 25126-32-3

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Peso molecolare: 1143.27

Ref: 7W-GL1683

Sincalide

CAS: 25126-32-3

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1143.2690

Ref: IN-DA002QKR

Sincalide(CCK-8)

CAS: 25126-32-3

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purezza: 95%~99%

Colore e forma: White to Off-white Powder

Peso molecolare: 1143.27

Ref: BP-BPPG057

Sincalide

CAS: 25126-32-3

Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purezza: 98.32% - 99.35%

Colore e forma: White Viscous

Peso molecolare: 1143.27

Ref: TM-TP1197

Sincalide

CAS: 25126-32-3

Sincalide is a cholecystokinin (CCK) analog that has been used as a pharmacological agent. It is an agonist for CCK-A receptors and inhibits the activity of protein kinase C. Sincalide also has been shown to suppress tumor growth in experimental models. A polymerase chain reaction analysis of cck-8, a rat CCK receptor gene, showed a high degree of homology with human CCK-A receptor genes. The physiological effects of sincalide are complex and depend on the presence or absence of other hormones such as insulin, glucagon, somatostatin, and leptin.

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 1,143.27 g/mol

Ref: 3D-FS41124

CCK-Octapeptide (26-33) (Sulfated Form)

CAS: 25126-32-3

CCK-Octapeptide (26-33) (Sulfated Form) is a peptide that has been shown to have a variety of biological effects. It has been found to enhance the activity of rifampicin against tuberculosis by increasing the activity of the kinase protein. CCK-Octapeptide (26-33) (Sulfated Form) also has natriuretic peptide-like activity, which means it can regulate blood pressure and fluid balance in the body. In addition, it has been shown to inhibit tumor growth and metastasis in animal models, possibly through its ability to modulate guanosine triphosphate-binding proteins. CCK-Octapeptide (26-33) (Sulfated Form) also exhibits trypsin inhibitory activity and thymidine uptake inhibition. Furthermore, it has been studied as a potential treatment for cancer and as an alternative to vasopressin or nesiritide in certain medical conditions where natriuretic peptides are used ther

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Purezza: Min. 95%

Peso molecolare: 1,143.3 g/mol

Ref: 3D-PCK-4100-V

Sincalide

CAS: 25126-32-3

Formula: C₄₉H₆₂N₁₀O₁₆S₃

Peso molecolare: 1143.27

Ref: ST-EA-CP-S88000