CAS 2576427-49-9

Formula: C21H21N3O3

InChI: InChI=1S/C21H21N3O3/c1-13-5-3-4-6-15(13)12-27-18-8-7-14(9-19(18)26-2)16-10-20(25)23-21-17(16)11-22-24-21/h3-9,11,16H,10,12H2,1-2H3,(H2,22,23,24,25)

InChI key: BVPWSDUNVDLFKY-UHFFFAOYSA-N

SMILES: CC1=CC=CC=C1COC2=C(C=C(C=C2)C3CC(=O)NC4=C3C=NN4)OC

VS3

CAS: 2576427-49-9

VS3 is an inhibitor of the YAP-TEAD interaction. By directly binding to the TEAD4 Interface 3 (Kd = 6 μM), VS3 disrupts the interaction between YAP and TEAD. It exhibits antiproliferative activity against HT29, HCT116, and A2780 cells. VS3 is useful for studying colorectal adenocarcinoma and ovarian cancer.

Formula: C₂₁H₂₁N₃O₃

Peso molecolare: 363.42

Ref: TM-T214392