CAS 2750895-97-5

MTX115325

Formula: C₁₈H₁₆N₆O₂

Sinonimi:

• MTX115325

MTX115325

CAS: 2750895-97-5

MTX115325 (Example 1) is a brain-penetrant USP30 inhibitor with an IC 50 of 12 nM, administered orally and exhibiting neuroprotective properties. It enhances ubiquitination (EC 50 =32 nM) of TOM20, a mitochondrial outer membrane protein and USP30 substrate, thereby promoting mitophagy. Additionally, MTX115325 prevents dopaminergic neuron loss and maintains striatal dopamine [1].

Formula: C₁₈H₁₆N₆O₂

Colore e forma: Solid

Peso molecolare: 348.36

Ref: TM-T86936