CAS 2752441-61-3

Formula: C17H12ClFN6O3S

InChI: InChI=1S/C17H12ClFN6O3S/c1-28-16-13(6-12(18)9-22-16)29(26,27)25-15-14(19)11(4-5-21-15)3-2-10-7-23-17(20)24-8-10/h4-9H,1H3,(H,21,25)(H2,20,23,24)

InChI key: ZHEOLZYPHNHWHG-UHFFFAOYSA-N

SMILES: COC1=C(C=C(C=N1)Cl)S(=O)(=O)NC2=NC=CC(=C2F)C#CC3=CN=C(N=C3)N

APL-4098

CAS: 2752441-61-3

APL-4098 is an orally active, selective, ATP-competitive GCN2 inhibitor with a Ki of 4.39 nM and a Kd of 2.9 nM. It reduces the phosphorylation levels of eIF2α and the expression of ATF4. APL-4098 impairs mitochondrial function and exhibits cytotoxicity against primary acute myeloid leukemia cells. It is applicable in studies related to acute myeloid leukemia.

Formula: C₁₇H₁₂ClFN₆O₃S

Peso molecolare: 434.83

Ref: TM-T218287