CAS 30220-46-3

Ingenolo

Descrizione:

Ingenolo, con il numero CAS 30220-46-3, è un composto naturale derivato dalla linfa del genere Euphorbia, in particolare dalla pianta Euphorbia peplus. È classificato come un diterpenoide e presenta una struttura complessa caratterizzata da un sistema di anelli fusi. Ingenolo ha attirato attenzione per le sue attività biologiche, in particolare per il suo potenziale come agente antitumorale. Funziona attraverso meccanismi come l'induzione dell'apoptosi nelle cellule tumorali e la modulazione delle risposte immunitarie. Inoltre, Ingenolo è stato studiato per le sue applicazioni dermatologiche, in particolare nel trattamento della cheratosi attinica, una condizione cutanea precocemente cancerosa. Il composto è noto per la sua tossicità relativamente bassa a dosi terapeutiche, rendendolo un candidato per formulazioni topiche. Tuttavia, la sua stabilità e solubilità possono variare, il che è un'importante considerazione nella sua applicazione. In generale, Ingenolo rappresenta un'area significativa di interesse sia in farmacologia che in chimica medicinale grazie ai suoi diversi effetti biologici e potenziali usi terapeutici.

Formula: C₂₀H₂₈O₅

InChI: InChI=1S/C20H28O5/c1-9-7-19-10(2)5-13-14(18(13,3)4)12(17(19)24)6-11(8-21)16(23)20(19,25)15(9)22/h6-7,10,12-16,21-23,25H,5,8H2,1-4H3/t10-,12+,13-,14+,15+,16-,19+,20-/m1/s1

InChI key: InChIKey=VEBVPUXQAPLADL-POYOOMFHSA-N

SMILES: O[C@@]12[C@@]3(C(=O)[C@]([C@]4([C@@](C[C@H]3C)(C4(C)C)[H])[H])(C=C(CO)[C@H]1O)[H])C=C(C)[C@@H]2O

Sinonimi:

• (1aR,2S,5R,5aR,6S,8aS,10aR)-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one
• (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-Octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
• (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one
• (1aR,5R,5aR,6S,9R,10aR)-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one
• 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one, 1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-, (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-
• 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one, 1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-, [1aR-(1aα,2β,5β,5aβ,6β,8aα,9α,10aα)]-
• 1aalpha,2alpha,5beta,5abeta,6beta,beta,9 alpha, 10,10aalpha-Octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1H-2,8aalpha-methano cyclopenta(a)cyclopropa(e)cyclodecen-11-one
• 5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one
• (-)-Ingenol
• Ingenol

1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one,1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-, (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-

CAS: 30220-46-3

Formula: C₂₀H₂₈O₅

Purezza: %

Colore e forma: Solid

Peso molecolare: 348.4333

Ref: IN-DA00I5O8

Ingenol

CAS: 30220-46-3

Ingenol

Formula: C₂₀H₂₈O₅

Purezza: ≥95%

Peso molecolare: 348.43

Ref: 54-BUP08868

Ingenol

CAS: 30220-46-3

Formula: C₂₀H₂₈O₅

Peso molecolare: 348.43

Ref: 7W-GK7087

Ingenol

CAS: 30220-46-3

Formula: C₂₀H₂₈O₅

Purezza: >99.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 348.44

Ref: 3B-I1112

Ingenol

CAS: 30220-46-3

Formula: C₂₀H₂₈O₅

Purezza: 95%~99%

Peso molecolare: 348.439

Ref: BP-BP0765

Ingenol

CAS: 30220-46-3

Formula: C₂₀H₂₈O₅

Peso molecolare: 348.44

Ref: 4Z-I-062001

Ingenol

CAS: 30220-46-3

Ingenol

Formula: C₂₀H₂₈O₅

Purezza: >99%

Colore e forma: Solid

Peso molecolare: 348.43332

Ref: 54-BII3022

Ingenol

CAS: 30220-46-3

Ingenol mebutate treats actinic keratosis, has anticancer properties, and may reactivate latent HIV.

Formula: C₂₀H₂₈O₅

Purezza: 99.78% - 99.87%

Colore e forma: Solid

Peso molecolare: 348.43

Ref: TM-T5S2017

Ingenol

CAS: 30220-46-3

Ingenol is a natural product, which belongs to the group of ingenol esters. It has been shown to have significant cytotoxic effects on solid tumours in vitro and in vivo. Ingenol is metabolized by esterases and glucuronidases, or hydrolyzed by esterases or glucuronidases, leading to the release of methyl ethyl erythritol tetranitrate (MEETN). The MEETN molecule is then converted into a nitrate radical that causes cell death. Ingenol is also effective against skin cancers. Studies have shown that it inhibits the growth of skin cancer cells through mitochondrial membrane potential and cytosolic calcium levels. This drug has a chemical stability of less than one week at room temperature.

Formula: C₂₀H₂₈O₅

Purezza: Min. 95%

Colore e forma: Solid

Peso molecolare: 348.43 g/mol

Ref: 3D-FI73952

Ingenol

CAS: 30220-46-3

M01922 - Ingenol

Formula: C₂₀H₂₈O₅

Purezza: 99+%

Colore e forma: Solid, Film

Peso molecolare: 348.439

Ref: 10-M01922

Ingenol

Prodotto controllato

CAS: 30220-46-3

Applications Ingenol, is the analogue of Ingenol 3-Angelate (I655800), which has anti-tumor activity when used topically for the treatment of actinic keratosis.
References Ogbourne, S.M., et al.: Cancer. Res., 64, 2833 (2004); Zayed, S.M., et al.: J. Cancer. Res. Clin. Oncol., 127, 40 (2001);

Formula: C₂₀H₂₈O₅

Colore e forma: Neat

Peso molecolare: 348.43

Ref: TR-I655795

Ingenol

CAS: 30220-46-3

Formula: C₂₀H₂₈O₅

Peso molecolare: 348.44

Ref: ST-EA-CP-I63000