CAS 3026367-07-4

JAK1/TYK2-IN-5

CAS: 3026367-07-4

JAK1/TYK2-IN-5 (compound A1) is an inhibitor of JAK1 and TYK2, exhibiting Ki values of 0.0044 nM for TYK2JH2, 0.02 nM for JAK1 JH2, 6.9 μM for JAK1 JH1, 0.79 μM for JAK2 JH1, 0.21 μM for JAK3 JH1, and 0.55 μM for TYK2JH1. Additionally, it inhibits STAT activation mediated by TYK2/JAK1, induced by IFNα.

Formula: C₂₆H₃₀N₇O₄P

Peso molecolare: 535.55

Ref: TM-T212955