CAS 3048196-52-4

Formula: C53H61FN8O7

InChI: InChI=1S/C53H61FN8O7/c1-33(34-5-7-35(8-6-34)42-15-20-55-46-12-9-36(54)29-44(42)46)50(65)56-37-3-2-4-41(30-37)69-40-18-23-61(24-19-40)49(64)32-58-21-16-38(17-22-58)59-25-27-60(28-26-59)39-10-11-43-45(31-39)53(68)62(52(43)67)47-13-14-48(63)57-51(47)66/h2-4,9-12,15,20,29-31,33-35,38,40,47H,5-8,13-14,16-19,21-28,32H2,1H3,(H,56,65)(H,57,63,66)/t33-,34?,35?,47?/m1/s1

InChI key: LDFDXTNMCGLUMQ-VOYGFYKOSA-N

SMILES: C[C@H](C1CCC(CC1)C2=C3C=C(C=CC3=NC=C2)F)C(=O)NC4=CC(=CC=C4)OC5CCN(CC5)C(=O)CN6CCC(CC6)N7CCN(CC7)C8=CC9=C(C=C8)C(=O)N(C9=O)C1CCC(=O)NC1=O

NU227326

CAS: 3048196-52-4

NU227326 is a PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) with a DC50 value of 4.5 nM. It effectively degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively. NU227326 exhibits favorable pharmacokinetic properties, with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours. (Pink: ligand for target protein IDO1 ligand-1; Black: linker; Blue: ligand for E3 ligase Cereblon).

Formula: C₅₃H₆₁FN₈O₇

Colore e forma: Solid

Peso molecolare: 941.099

Ref: TM-T205704