CAS 3054043-85-2

Formula: C28H28N4O2

InChI: InChI=1S/C28H28N4O2/c1-20-24(21-8-4-3-5-9-21)11-6-12-25(20)26-14-13-23(28(32-26)34-2)19-30-16-17-31-27(33)22-10-7-15-29-18-22/h3-15,18,30H,16-17,19H2,1-2H3,(H,31,33)

InChI key: LAWJEYCPOCTNIU-UHFFFAOYSA-N

SMILES: CC1=C(C=CC=C1C2=NC(=C(C=C2)CNCCNC(=O)C3=CN=CC=C3)OC)C4=CC=CC=C4

PD-L1/Nampt-IN-1

CAS: 3054043-85-2

PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.

Formula: C₂₈H₂₈N₄O₂

Colore e forma: Solid

Peso molecolare: 452.55

Ref: TM-T212272