CAS 3065556-04-6

Formula: C28H35N3O5

InChI: InChI=1S/C28H35N3O5/c32-25-17-26(33)23(16-22(25)20-7-8-20)28(35)31-18-21(19-5-2-1-3-6-19)15-24(31)27(34)29-9-4-10-30-11-13-36-14-12-30/h1-3,5-6,16-17,20-21,24,32-33H,4,7-15,18H2,(H,29,34)/t21-,24+/m0/s1

InChI key: XCXDMGICEJTIPU-XUZZJYLKSA-N

SMILES: C1CC1C2=CC(=C(C=C2O)O)C(=O)N3C[C@H](C[C@@H]3C(=O)NCCCN4CCOCC4)C5=CC=CC=C5

Hsp90-IN-38

CAS: 3065556-04-6

Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.

Formula: C₂₈H₃₅N₃O₅

Colore e forma: Solid

Peso molecolare: 493.595

Ref: TM-T205493