CAS 3081876-96-9

FXR DUBTAC IN-1

CAS: 3081876-96-9

FXRDUBTAC IN-1 (compound D11) is a deubiquitinase-targeting chimera (DUBTAC) designed to target FXR, with a Ka value of 2.12e-5 M. This compound recruits the deubiquitinase OTUB1 to form a ternary complex with FXR, reducing FXR's polyubiquitination levels. It prevents FXR degradation via the ubiquitin-proteasome pathway, thereby increasing FXR protein levels. FXRDUBTAC IN-1 is used in the study of cholestatic liver injury.

Formula: C₄₃H₆₆N₄O₇

Peso molecolare: 751.01

Ref: TM-T218558