CAS 3085155-69-4

CAIIVII-IN-1

Formula: C₂₇H₂₃ClN₈O₅S₂

Sinonimi:

• CAIIVII-IN-1
• 1H-1,2,3-Triazole-4-carboxylic acid, 1-[4-(aminosulfonyl)phenyl]-5-methyl-, 2-[[3-(4-chlorophenyl)-1-[4-(methylsulfonyl)phenyl]-1H-pyrazol-4-yl]methylene]hydrazide

CAII/VII-IN-1

CAS: 3085155-69-4

CAII/VII-IN-1 is an orally active inhibitor of hCA II (KI= 12.3 nM) and hCA VII (KI= 22.6 nM), showing no significant activity towards hCA I. In vivo, it demonstrates excellent neuroprotective properties in a Pilocarpine-induced epilepsy model. It upregulates KCC2 and inhibits mTOR, contributing to its neuroprotective effects. CAII/VII-IN-1 exhibits no significant neurotoxicity or changes in liver and kidney function, making it a useful compound for epilepsy research.

Formula: C₂₇H₂₃ClN₈O₅S₂

Peso molecolare: 639.1

Ref: TM-T213638