CAS 3111011-76-5

Formula: C36H45ClN7O3P

InChI: InChI=1S/C36H45ClN7O3P/c1-47-32-22-27(10-11-30(32)40-36-38-23-29(37)34(41-36)39-31-6-4-5-7-33(31)48(2,3)46)42-14-12-26(13-15-42)43-16-18-44(19-17-43)35(45)28-21-24-8-9-25(28)20-24/h4-11,22-26,28H,12-21H2,1-3H3,(H2,38,39,40,41)

InChI key: SMZHXZJSLALQAC-UHFFFAOYSA-N

SMILES: COC1=C(C=CC(=C1)N2CCC(CC2)N3CCN(CC3)C(=O)C4CC5CC4C=C5)NC6=NC=C(C(=N6)NC7=CC=CC=C7P(=O)(C)C)Cl

ALK-IN-35

CAS: 3111011-76-5

ALK-IN-35 is an ALK degrader with an IC₅₀ of 0.74 nM. It inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes the formation of partially unfolded ALK conformations, and induces proteasome-mediated degradation of ALK. ALK-IN-35 effectively inhibits cancer cell proliferation and is applicable in research related to non-small-cell lung cancer.

Formula: C₃₆H₄₅ClN₇O₃P

Peso molecolare: 690.21

Ref: TM-T218942