CAS 31618-90-3

dietil (tosilossi)metilfosfonato

Descrizione:

dietil (tosilossi)metilfosfonato, con il numero CAS 31618-90-3, è un composto organofosforato caratterizzato dalla sua struttura di fosfonato, che include un atomo di fosforo legato a un atomo di ossigeno e a un gruppo alchile. Questo composto presenta due gruppi etile e un gruppo tosile, che ne aumenta la reattività e la solubilità nei solventi organici. È tipicamente un liquido incolore o giallo pallido ed è noto per le sue applicazioni nella sintesi organica, in particolare come reagente nella preparazione di vari fosfonati e fosfonamidati. La presenza del gruppo tosile contribuisce alla sua natura elettrofila, rendendolo utile nelle reazioni di sostituzione nucleofila. Inoltre, dietil (tosilossi)metilfosfonato può mostrare tossicità moderata, comune tra i composti organofosforati, richiedendo una manipolazione attenta e misure di sicurezza appropriate durante l'uso. Le sue proprietà chimiche, inclusa stabilità e reattività, lo rendono un intermedio prezioso nella sintesi di prodotti farmaceutici e agrochimici.

Formula: C₁₂H₁₉O₆PS

InChI: InChI=1/C12H19O6PS/c1-4-16-19(13,17-5-2)10-18-20(14,15)12-8-6-11(3)7-9-12/h6-9H,4-5,10H2,1-3H3

InChI key: InChIKey=UOEFFQWLRUBDME-UHFFFAOYSA-N

SMILES: S(OCP(OCC)(OCC)=O)(=O)(=O)C1=CC=C(C)C=C1

Sinonimi:

• (Diethoxyphosphoryl)Methyl 4-Methylbenzenesulfonate
• 4-Methylbenzenesulfonic acid (diethoxyphosphoryl)methyl ester
• Desmp
• Detp
• Diethoxyphosphorylmethyl tosylate
• Diethyl P-Toluenesulfonyl Oxymethyl Phosphonate
• Diethyl P-Tosyloxymethylphosphonate
• Diethyl P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]phosphonate
• Diethyl [[(P-Toluenesulfonyl)Oxy]Methyl]Phosphonate
• Diethyl [[[(4-Tolyl)Sulfonyl]Oxy]Methyl]Phosphonate
• Diethyl p-toluene sulfonyl oxymethyl phosphonate
• Diethyl p-toluene sulfonyloxy methyl phosphonate
• Diethyl  p-toluenesulfonyloxymethylphosphonate
• PMPA monohydrate
• Phosphonic acid, (hydroxymethyl)-, diethyl ester, p-toluenesulfonate
• Phosphonic acid, P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-, diethyl ester
• Phosphonic acid, [[[(4-methylphenyl)sulfonyl]oxy]methyl]-, diethyl ester
• Tosyloxymethyl Diethyl Phosphonate
• [[[(4-Tolyl)Sulfonyl]Oxy]Methyl]Phosphonic Acid Diethyl Ester
• Diethyl(tosyloxy)methylphosphonate
• Diethyl p-toluene sulfonyloxy methyl phosphonate(DESMP)
• PHOSPHONIC ACID, [[[(4-METHYLPHENYL)SULFONYL]OXY]METHYL]-, DIETHYL ESTER (9CI)
• Diethylp-toluenesulfonyloxymenthylphosphonate
• p-toluenesulfonyloxy methylphosphonate
• DIETHYL 4-TOLUENESULFONYLOXYMETHYLPHOSPHONATE
• DETHYL (TOSYLOXY) METHYLPHOSPHONATE
• TOLUENE-4-SULFONIC ACID DIETHOXY-PHOSPHORYLMETHYL ESTER
• DIETHYL(TOSYLOXYMETHYL)PHOSPHONATE
• Diethyl(Tosyloxy)methylphosphonte
• 4-METHYLPHENYL]SULFONYL]OXY]METHYLPHOSPHONICACIDDIETHYLESTER

Diethyl (p-Toluenesulfonyloxymethyl)phosphonate

CAS: 31618-90-3

Formula: C₁₂H₁₉O₆PS

Purezza: >97.0%(GC)

Colore e forma: Colorless to Light yellow clear liquid

Peso molecolare: 322.31

Ref: 3B-D4968

(Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate

CAS: 31618-90-3

Formula: C₁₂H₁₉O₆PS

Purezza: 98%

Colore e forma: Liquid

Peso molecolare: 322.3144

Ref: IN-DA0034QG

Diethyl(tosyloxy)methylphosphonate

CAS: 31618-90-3

Diethyl(tosyloxy)methylphosphonate

Formula: C₁₂H₁₉O₆PS

Purezza: 98%

Colore e forma: Solid-Low Melt

Peso molecolare: 322.31442

Ref: 54-OR53035

Tenofovir Impurity 36

CAS: 31618-90-3

Formula: C₁₂H₁₉O₆PS

Peso molecolare: 322.31

Ref: 4Z-T-0280

Tenofovir Impurity 66

CAS: 31618-90-3

Formula: C₁₂H₁₉O₆PS

Peso molecolare: 322.31

Ref: ST-EA-CP-T5013

Diethyl p-tosyloxymethylphosphonate

CAS: 31618-90-3

Diethyl p-tosyloxymethylphosphonate is an organic compound that is used in the synthesis of tenofovir. It is a salt of diethyl phosphate and p-toluenesulfonyl chloride, which reacts with magnesium chloride to form diethyl p-tosyloxymethylphosphonate. Diethyl p-tosyloxymethylphosphonate is also used as a reagent for the acylation reaction of phosphites and chlorides. This reaction has been shown to be useful in the synthesis of many organic compounds, including drugs such as methyldopa and acetazolamide. Diethyl p-tosyloxymethylphosphonate has also been shown to have anti-cancer properties. The mechanism of this effect is not well understood, but it may be due to inhibition of DNA replication or the induction of apoptosis by reactive oxygen species (ROS).

Formula: C₁₂H₁₉O₆PS

Purezza: Min. 95%

Colore e forma: Colorless Clear Liquid

Peso molecolare: 322.32 g/mol

Ref: 3D-FD10108

(Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate

CAS: 31618-90-3

Formula: C₁₂H₁₉O₆PS

Purezza: 97%

Colore e forma: White powder

Peso molecolare: 322.31

Ref: 10-F213393

Diethyl p-Toluenesulfonyloxymethylphosphonate

Prodotto controllato

CAS: 31618-90-3

Applications Diethyl p-Toluenesulfonyloxymethylphosphonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),

Formula: C₁₂H₁₉O₆PS

Colore e forma: Neat

Peso molecolare: 322.31

Ref: TR-D445260