CAS 320-67-2

Azacitidina

Descrizione:

Azacitidina, con il numero CAS 320-67-2, è un analogo nucleosidico della citidina, caratterizzato dalla presenza di un atomo di azoto nell'anello pirimidinico. Questa modifica altera la sua attività biologica, rendendolo un potente inibitore della metilazione del DNA. Azacitidina è utilizzato principalmente nel trattamento di alcuni tipi di cancro, in particolare sindromi mielodisplastiche e leucemia mieloide acuta, poiché può indurre differenziazione e apoptosi nelle cellule maligne. Il composto viene tipicamente somministrato per iniezione e ha una vita media relativamente breve nel corpo. Il suo meccanismo d'azione implica l'incorporazione in RNA e DNA, portando a ipometilazione di geni che sono silenziati nel cancro. Azacitidina è anche noto per la sua capacità di riattivare geni soppressori tumorali, contribuendo ai suoi effetti terapeutici. Tuttavia, può causare effetti collaterali, tra cui mielosoppressione, disturbi gastrointestinali e potenziali rischi a lungo termine. In generale, Azacitidina rappresenta un significativo progresso nella terapia epigenetica, evidenziando l'importanza della metilazione del DNA nel trattamento del cancro.

Formula: C₈H₁₂N₄O₅

InChI: InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1

InChI key: InChIKey=NMUSYJAQQFHJEW-KVTDHHQDSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)N=C2

Sinonimi:

• 1,3,5-Triazin-2(1H)-one, 4-amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 1,3,5-Triazin-2(1H)-one, 4-amino-1-β-D-ribofuranosyl-
• 2-(β-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-on
• 2-(β-D-ribofurannosyl)-4-amino-1,3,5-triazine-2-one
• 2-(β-D-ribofuranosil)-4-amino-1,3,5-triazin-2-ona
• 2-(β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2-one
• 4-Amino-1-Beta-D-Ribofuranosyl-S-Triazin-2(1H)-On
• 4-Amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1,3,5-triazin-2(1H)-one
• 4-amino-1-D-lyxofuranosyl-1,3,5-triazin-2(1H)-one
• 4-amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
• 4-amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one
• 4-amino-1-pentofuranosyl-1,3,5-triazin-2(1H)-one
• 5 Azc
• 5-Ac
• 5-Azac
• 5-Azacitidine
• 5-Azcr
• 5-Triazin-2(1H)-One,4-Amino-1-Beta-D-Ribofuranosyl-3
• Antibiotic u 18496
• Antibioticu18496
• Azacitidine
• Azacytidine
• Cc 486
• Ladakamycin
• Ledakamycin
• Mylosar
• Nci-C01569
• Nsc 103-627
• Nsc-102816
• U 18496
• U18496
• Vidaza
• Wr 183027
• s-Triazin-2(1H)-one, 4-amino-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• s-Triazin-2(1H)-one, 4-amino-1-β-D-ribofuranosyl-
• 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

5-Azacytidine

CAS: 320-67-2

Formula: C₈H₁₂N₄O₅

Purezza: >98.0%(T)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 244.21

Ref: 3B-A2033

5-Azacytidine, 98%

CAS: 320-67-2

Causes DNA demethylation or hemi-demethylation; a powerful mutagen

Formula: C₈H₁₂N₄O₅

Purezza: 98%

Colore e forma: White to off-white, Powder or crystals or crystalline powder

Peso molecolare: 244.21

Ref: 02-J64159

Azacitidine

CAS: 320-67-2

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₈H₁₂N₄O₅

Colore e forma: White Off-White Powder

Peso molecolare: 244.08077

Ref: 45-1045520

5-Azacytidine

CAS: 320-67-2

5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.

Formula: C₈H₁₂N₄O₅

Purezza: 99.31% - 99.87%

Colore e forma: White Solid

Peso molecolare: 244.2047

Ref: TM-T1339

5-Azacytidine

CAS: 320-67-2

5-Azacytidine

Formula: C₈H₁₂N₄O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 244.2

Ref: 54-OR1011812

5-Azacytidine

CAS: 320-67-2

5-Azacytidine

Formula: C₈H₁₂N₄O₅

Purezza: ≥98%

Peso molecolare: 244.2

Ref: 54-BUP15112

5-Azacytidine

CAS: 320-67-2

Formula: C₈H₁₂N₄O₅

Purezza: ≥ 98.0% (dried basis)

Colore e forma: White to off-white crystalline powder

Peso molecolare: 244.20

Ref: 7W-GA4671

Azacitidine

CAS: 320-67-2

Formula: C₈H₁₂N₄O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 244.21

Ref: 4Z-A-811

Azacitidine Impurity 3

CAS: 320-67-2

Formula: C₁₄H₁₈N₄O₈

Colore e forma: Off-White Solid

Peso molecolare: 370.32

Ref: 4Z-A-8110

Azacitidine

Prodotto controllato

CAS: 320-67-2

Formula: C₈H₁₂N₄O₅

Colore e forma: Neat

Peso molecolare: 244.20

Ref: 86-MM1259.00

5-Azacytidine-15N4

Prodotto controllato

CAS: 320-67-2

Applications Labelled Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.
References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)

Formula: C₈H₁₂₁₅N₄O₅

Colore e forma: Neat

Peso molecolare: 248.18

Ref: TR-A796002

5-Azacytidine

CAS: 320-67-2

Applications A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.
References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)

Formula: C₈H₁₂N₄O₅

Colore e forma: Neat

Peso molecolare: 244.2

Ref: TR-A796000

5-Azacytidine

CAS: 320-67-2

4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one

Formula: C₈H₁₂N₄O₅

Purezza: 95%

Peso molecolare: 244.2

Ref: IN-DG8347

Azacitidine

CAS: 320-67-2

Formula: C₈H₁₂N₄O₅

Peso molecolare: 244.20

Ref: ST-EA-CP-A35000

5-Azacytidine

CAS: 320-67-2

An azanucleoside and epigenetic modulator that interferes with nucleic acid metabolism. The compound gets incorporated into RNA and inhibits ribonucleotide reductase subunit RRM2 in leukemia cell lines. Intracellularly, 5-azacytidine can get converted into 2′-deoxy-5-azacytidine (decitabine) and subsequently incorporated in DNA, where it irreversibly inhibits DNMT1 methyltransferase. In human epithelial cell lines, this compound decreases Src-activated expression of a histone chaperone CAF1 and inhibits cell motility and invasiveness.

Formula: C₈H₁₂N₄O₅

Purezza: Min. 95%

Colore e forma: White Off-White Powder

Peso molecolare: 244.21 g/mol

Ref: 3D-NA02947

Azacitidine-[13C5]

CAS: 320-67-2

Formula: C₈H₁₂N₄O₅

Colore e forma: Solid

Peso molecolare: 244.2

Ref: BE-MC-7318

5-Azacytidine

CAS: 320-67-2

Formula: C₈H₁₂N₄O₅

Colore e forma: Solid

Peso molecolare: 244.2

Ref: BE-RMCA339000

5-Azacytidine

CAS: 320-67-2

Formula: C₈H₁₂N₄O₅

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 244.207

Ref: 10-F492447

5-Azacytidine extrapure, 98%

CAS: 320-67-2

Formula: C₈H₁₂N₄O₅

Purezza: min. 98%

Colore e forma: White to off-white, Crystalline powder

Peso molecolare: 244.21

Ref: SR-34476

5-Azacytidine

CAS: 320-67-2

Formula: C₈H₁₂N₄O₅

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 244.2047

Ref: IN-DA003824