CAS 33069-62-4

Paclitaxel

Descrizione:

Paclitaxel, con il numero CAS 33069-62-4, è un prodotto naturale complesso e un agente chemioterapico utilizzato principalmente nel trattamento di vari tipi di cancro, tra cui cancro ovarico, al seno e ai polmoni. È derivato dalla corteccia dell'albero di tasso del Pacifico (Taxus brevifolia) ed è classificato come un taxano. Paclitaxel funziona stabilizzando i microtubuli e prevenendo la loro depolimerizzazione, il che interrompe il normale processo di divisione cellulare, portando infine all'apoptosi nelle cellule tumorali. Il composto è caratterizzato dalla sua struttura unica, che include un sistema ad anello di taxano e diversi gruppi funzionali che contribuiscono alla sua attività biologica. Paclitaxel viene tipicamente somministrato per via endovenosa e ha una solubilità relativamente bassa in acqua, richiedendo spesso formulazioni con solventi come Cremophor EL per uso clinico. I suoi effetti collaterali possono includere neutropenia, reazioni di ipersensibilità e neuropatia periferica. A causa della sua efficacia e meccanismo d'azione, Paclitaxel rimane un pilastro nelle terapie oncologiche, sebbene il suo uso sia spesso accompagnato da un attento monitoraggio e assistenza di supporto.

Formula: C₄₇H₅₁NO₁₄

InChI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

InChI key: InChIKey=RCINICONZNJXQF-MZXODVADSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]

Sinonimi:

• 5β,20-Epoxy-1,2a,4,7β,10β,13α-hexahydroxy-tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7,11-Methano-5H-Cyclodeca[3,4]Benz[1,2-B]Oxete Benzenepropanoic Acid Deriv.
• Abi 007
• Abraxane
• Anzatax
• Apealea
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Bms 181339-01
• Capxol
• Coroflex Please
• Cremophor-free paclitaxel
• Cyclopax
• Cynviloq
• Cypher select
• Dhp 107
• Ebetaxel
• EmPAC
• EndoTAG 1
• Genaxol
• Genetaxyl
• Genexol
• Genexol-PM
• Ig 001
• Ig 002
• Infinnium
• Intaxel
• Lep-Etu
• Liposome-entrapped paclitaxel easy-to-use
• Mbt 0206
• Mitotax
• Nab-paclitaxel
• Nanotax
• Nanoxel
• Nk 105
• Nsc 125973
• OncoGel
• Onxal
• Oraxol
• Pacitaxel
• Pacliex
• Padexol
• Paxene
• Pazenir
• Plaxicel
• Qw 8184
• Sindaxel
• TAXUS Express
• TAXUS stent
• Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxy-, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• TaxAlbin
• Taxal
• Taxol
• Taxol A
• Taxus
• Taxus Liberte
• Tocosol Paclitaxel

Paclitaxel

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 853.92

Ref: 3B-P1632

Paclitaxel, 99.5+%

CAS: 33069-62-4

Paclitaxel, 33069-62-4, also known as Taxol, is an anticancer agent which acts through disruption of microtubule growth. Learn more at Thermo Fisher Scientific.

Formula: C₄₇H₅₁NO₁₄

Purezza: 99.5+%

Colore e forma: White to cream, Crystalline powder or granular

Peso molecolare: 853.92

Ref: 02-J62734

PACLITAXEL NATURAL FOR PEAK IDENTIFICATION CRS

CAS: 33069-62-4

PACLITAXEL NATURAL FOR PEAK IDENTIFICATION CRS

Formula: C₄₇H₅₁NO₁₄

Peso molecolare: 853.9061

Ref: 41-Y0000700

PACLITAXEL CRS

CAS: 33069-62-4

PACLITAXEL CRS

Formula: C₄₇H₅₁NO₁₄

Colore e forma: Crystalline Powder. White. Powder.

Peso molecolare: 853.9061

Ref: 41-Y0000698

PACLITAXEL SEMI-SYNTHETIC FOR SYSTEM SUITABILITY CRS

CAS: 33069-62-4

PACLITAXEL SEMI-SYNTHETIC FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0000739

PACLITAXEL SEMI-SYNTHETIC FOR PEAK IDENTIFICATION CRS

CAS: 33069-62-4

PACLITAXEL SEMI-SYNTHETIC FOR PEAK IDENTIFICATION CRS

Formula: C₄₇H₅₁NO₁₄

Peso molecolare: 853.9061

Ref: 41-Y0000719

Paclitaxel

CAS: 33069-62-4

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₄₇H₅₁NO₁₄

Colore e forma: White Off-White Powder

Peso molecolare: 853.33096

Ref: 45-1491332

Paclitaxel

CAS: 33069-62-4

Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer.

Formula: C₄₇H₅₁NO₁₄

Purezza: 98% - 99.92%

Colore e forma: White Powder

Peso molecolare: 853.91

Ref: TM-T0968

Paclitaxel

CAS: 33069-62-4

Paclitaxel

Purezza: ≥98%

Peso molecolare: 853.91g/mol

Ref: 54-BUP20834

Paclitaxel

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Purezza: 97.0 - 102.0 % (anhydrous basis)

Colore e forma: White powder

Peso molecolare: 853.91

Ref: 7W-GA4564

Paclitaxel (Docetaxel EP Impurity F)

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Colore e forma: White To Off-White Solid

Peso molecolare: 853.92

Ref: 4Z-P-283

Paclitaxel

CAS: 33069-62-4

Paclitaxel is a potent anticancer medication which can promote microtubule (MT) assembly, inhibits MT depolymerization, and changes MT dynamics required for mitosis and cell proliferation. Paclitaxel can induce ototoxicity in rats.

Formula: C₄₇H₅₁NO₁₄

Purezza: 95%~99%

Peso molecolare: 853.918

Ref: BP-BP1055

Paclitaxel (1mg×5)

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 853.92

Ref: 3B-P3207

Paclitaxel

Prodotto controllato

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Colore e forma: Neat

Peso molecolare: 853.91

Ref: 04-C15839000

Paclitaxel

Prodotto controllato

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Colore e forma: Neat

Peso molecolare: 853.91

Ref: 86-MM1489.00

Paclitaxel from Taxus Mairei

CAS: 33069-62-4

Paclitaxel from Taxus Mairei

Formula: C₄₇H₅₁NO₁₄

Purezza: By hplc: consistent with structure (Typical Value in Batch COA)

Colore e forma: solid

Peso molecolare: 853.91g/mol

Ref: 54-BIP1002

Taxol

CAS: 33069-62-4

Oxygen-heterocyclic compound

Formula: C₄₇H₅₁NO₁₄

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 853.92

Ref: 5G-89806

Paclitaxel

CAS: 33069-62-4

Applications An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

Formula: C₄₇H₅₁NO₁₄

Colore e forma: Off-White

Peso molecolare: 853.91

Ref: TR-P132500

Paclitaxel-13C6

Prodotto controllato

CAS: 33069-62-4

Applications Paclitaxel-13C is the labeled analogue of Paclitaxel (P132500). Paclitaxel is an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

Formula: C₄₁₁₃C₆H₅₁NO₁₄

Colore e forma: Neat

Peso molecolare: 859.86

Ref: TR-P132504

Paclitaxel

CAS: 33069-62-4

Tubulin ligand which promotes microtubule assembly and stabilises microtubule cytoskeleton against depolymerisation. The compound has anti-tumoral activity since its interference with cytoskeleton dynamics affects the assembly of mitotic spindle, segregation of chromosomes, cell division and blocks the cell cycle in G1 or M phase. The compound is also used for the purification of tubulin or microtubule-associated proteins.

Formula: C₄₇H₅₁NO₁₄

Purezza: Min. 95%

Colore e forma: White Clear Liquid

Peso molecolare: 853.91 g/mol

Ref: 3D-FP10637