CAS 33507-63-0

Sostanza P

Descrizione:

Sostanza P è un neuropeptide che funge principalmente da neurotrasmettitore e neuromodulatore nei sistemi nervoso centrale e periferico. È composto da undici aminoacidi ed è parte della famiglia dei peptidi tachichinina. Caratteristicamente, Sostanza P è coinvolto nella trasmissione dei segnali di dolore e gioca un ruolo significativo nelle risposte infiammatorie, nello stress e nell'ansia. Si lega al recettore della neurochinina-1 (NK1), che è ampiamente distribuito nel cervello e in altri tessuti, influenzando vari processi fisiologici. Oltre al suo ruolo nella percezione del dolore, Sostanza P è implicato nella regolazione dell'umore, dell'ansia e della risposta immunitaria. Il peptide si trova tipicamente in alte concentrazioni in aree del cervello associate alla regolazione del dolore e delle emozioni. A causa del suo coinvolgimento in varie condizioni patofisiologiche, Sostanza P è stato un obiettivo per interventi terapeutici nella gestione del dolore e nei disturbi psichiatrici. Il suo numero CAS, 33507-63-0, è utilizzato per l'identificazione in database chimici e contesti normativi.

Formula: C63H98N18O13S

InChI: InChI=1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1

InChI key: ADNPLDHMAVUMIW-CUZNLEPHSA-N

SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCN=C(N)N)N

Sinonimi:

• 2: PN: JP2005049164 SEQID: 2 claimed protein
• 21: PN: WO0181408 SEQID: 44 claimed protein
• 36: PN: WO2007058336 SEQID: 36 claimed protein
• 44: PN: WO2005016244 PAGE: 68 claimed protein
• 690: PN: WO2004005342 PAGE: 46 claimed protein
• L-Methioninamide, L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-
• Neurokinin P
• Substance P (1-11)
• Substance P (peptide)
• Substance P (smooth-muscle stimulant)
• Substanz P

Substance P

CAS: 33507-63-0

For cellular and molecular biology applications

Formula: C₆₃H₉₈N₁₈O₁₃S

Colore e forma: Lyophilized Powder, White

Peso molecolare: 1347.65

Ref: 02-J63489

Substance P

CAS: 33507-63-0

Substance P

Formula: C₆₃H₉₈N₁₈O₁₃S

Purezza: ≥98%

Peso molecolare: 1347.63

Ref: 54-BUP04957

Substance P

CAS: 33507-63-0

Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.

Formula: C₆₃H₉₈N₁₈O₁₃S

Purezza: 98% - 99.51%

Colore e forma: White Solid

Peso molecolare: 1347.63

Ref: TM-TP1087

Substance P

CAS: 33507-63-0

Formula: C₆₃H₉₈N₁₈O₁₃S

Purezza: 95.0%

Colore e forma: Solid

Peso molecolare: 1347.65

Ref: 10-F047247

Substance P (Human, Bovine, Rat, Mouse)

CAS: 33507-63-0

Substance P is a member of the tachykinin neuropeptide family which is produced in the central nervous system (CNS) and acts through its specific receptor neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is involved in: pain perceptions as a neurotransmitter; gut motility; increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research. This product is available as a 0.5 mg vial.

Formula: C₆₃H₉₈N₁₈O₁₃S

Purezza: Min. 95%

Peso molecolare: 1,347.6 g/mol

Ref: 3D-PSP-4014-V

Substance P

CAS: 33507-63-0

Substance P is a protein that belongs to the tachykinin family of neuropeptides. It is a powerful activator of the inflammatory response, and also inhibits cell growth in cancer cells. There has been some evidence that Substance P may be useful in treating Alzheimer's disease, due to its ability to inhibit the proliferation of certain brain cells. The levels of substance P are increased in patients with Alzheimer's, and it has been hypothesized that this increase may be related to the progression of the disease.

Formula: C₆₃H₉₈N₁₈O₁₃S

Purezza: Min. 95%

Peso molecolare: 1,347.63 g/mol

Ref: 3D-FS73619

Substance P

CAS: 33507-63-0

Substance P (SP), a neuropeptide discovered already in 1931, is closely related to neurokinin A. SP acts as neurotransmitter and as neuromodulator.

Formula: C₆₃H₉₈N₁₈O₁₃S

Purezza: ≥ 98%

Colore e forma: White Lyophilisate

Peso molecolare: 1347.65

Ref: 01-4010600