CAS 34031-32-8

Auranofin

Descrizione:

Auranofin è un composto contenente oro utilizzato principalmente nel trattamento dell'artrite reumatoide. Appartiene alla classe di farmaci noti come sali d'oro, che hanno proprietà anti-infiammatorie. La formula chimica di Auranofin è C20H17AuO9PS, indicando che contiene oro, zolfo, fosforo e diversi componenti organici. Auranofin agisce modulando la risposta immunitaria e inibendo l'attività di alcuni enzimi coinvolti nell'infiammazione. Viene tipicamente somministrato per via orale ed è noto per la sua tossicità relativamente bassa rispetto ad altri composti d'oro. Tuttavia, può comunque causare effetti collaterali, tra cui disturbi gastrointestinali e potenziali reazioni allergiche. Il meccanismo d'azione del composto implica l'inibizione dell'attivazione dei macrofagi e la modulazione della produzione di citochine, contribuendo ai suoi effetti terapeutici. Auranofin ha anche suscitato interesse nella ricerca per le sue potenziali applicazioni oltre l'artrite, comprese le sue proprietà antiparassitarie e anticancro. Come per qualsiasi medicinale, il suo uso deve essere monitorato da professionisti sanitari per gestire efficacemente eventuali effetti avversi.

Formula: C₂₀H₃₄AuO₉PS

InChI: InChI=1/C6H15P.Au/c1-4-7(5-2)6-3;/h4-6H2,1-3H3;/q;+1

InChI key: InChIKey=AUJRCFUBUPVWSZ-XTZHGVARSA-M

SMILES: O(C(C)=O)[C@@H]1[C@@H](OC(C)=O)[C@H]([S-][Au+][P](CC)(CC)CC)O[C@H](COC(C)=O)[C@H]1OC(C)=O

Sinonimi:

• (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate
• 3,4,5-Triacetoxy-6-(Acetoxymethyl)Tetrahydropyran-2-Thiolate
• Aktil
• Auranofina
• Auranofine
• Crisinor
• Crisofin
• Gold Salt
• Gold(+1) Cation
• Gold, (1-thio-β-<span class="text-smallcaps">D</span>-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate
• Gold, (1-thio-β-<span class="text-smallcaps">D</span>-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-
• Gold, (1-thio-β-D-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate
• Gold, (1-thio-β-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-
• Gold, [1-(thio-κS)-β-<span class="text-smallcaps">D</span>-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-
• Gold, [1-(thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-
• Nsc 321521
• Phosphine, Triethyl-, Gold(1+) Salt (1:1)
• Ridaura
• Ridauran
• Skf 39162
• Skf 39162D
• Triethylphosphonium
• [(Tetra-O-acetyl-β-<span class="text-smallcaps">D</span>-glucopyranosyl)thio](triethylphosphine)gold
• [(Tetra-O-acetyl-β-D-glucopyranosyl)thio](triethylphosphine)gold
• [1-(Thio-κS)-β-<span class="text-smallcaps">D</span>-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)gold
• β-<span class="text-smallcaps">D</span>-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, gold complex
• β-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, gold complex
• [1-(Thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)gold
• 3,4,5-Triacetyloxy-6-(acetyloxymethyl) oxane-2-thiolate triethylphosphanium
• gold,(1-thio-beta-d-glucopyranose2,3,4,6-tetraacetato-s)(triethylphosphine)
• Gold, [1-(thio-kS)-b-D-glucopyranose2,3,4,6-tetraacetato](triethylphosphine)-
• sk&f39162
• 2,3,4,6-tetra-o-acetyl-1-thio-beta-d-glucopyranosato-s(triethylphosphine)gol
• sk&f39162d
• (1-thio-beta-d-glucopyranosato)-(triethylphosphine)gold2,3,4,6-tetraacetate
• (1-Thio-β-D-glucopyranosato)(triethylphosphine)gold-2，3，4，6-tetraacetate
• gold,(1-thio-beta-d-glucopyranosato-s)(triethylphosphine)-,2,3,4,6-tetraaceta
• AURANOFIN
• sk&fd-39162
• Adtil
• Auranofin, >=98%

Auranofin

CAS: 34031-32-8

Auranofin (SKF-39162), an antirheumatic, treats rheumatoid arthritis and eases joint pain and stiffness.

Formula: C₂₀H₃₄AuO₉PS

Purezza: 97.00% - 99.41%

Colore e forma: Yellow Solid

Peso molecolare: 678.484

Ref: TM-T1303

(1-Thio-β-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate

CAS: 34031-32-8

Formula: C₂₀H₃₄AuO₉PS

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 678.4839

Ref: IN-DA00382F

((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(Acetoxymethyl)Tetrahydro-2H-Pyran-2-Thio)(Triethylphosphine)Gold

CAS: 34031-32-8

((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(Acetoxymethyl)Tetrahydro-2H-Pyran-2-Thio)(Triethylphosphine)Gold

Formula: C₂₀H₃₆AuO₉PS

Purezza: 98% (HPLC)

Colore e forma: Solid

Peso molecolare: 678.5

Ref: 54-IN11585

Auranofin

CAS: 34031-32-8

Auranofin

Formula: C₂₀H₃₄AuO₉PS

Purezza: ≥90%

Peso molecolare: 678.49

Ref: 54-BUP13236

Auranofin

Prodotto controllato

CAS: 34031-32-8

Applications Auranofin is a new oral gold-based antiarthritis drug. Auranofin inhibits various leukocyte activation pathways at multiple sites. Auranofin inhibits the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions related to its inhibition of mitochondrial thioredoxin reductase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kizu, R., et al.: Chem. Pharm. Bull., 41, 1261 (1993), Itokazu, M., et al.: Clin. Ther., 17, 60 (1995), Kean, W.F., et al.: Br. J. Rheumatol., 36, 560 (1997),

Formula: C₂₀H₃₄AuO₉PS

Colore e forma: Neat

Peso molecolare: 678.48

Ref: TR-A794750

Auranofin

CAS: 34031-32-8

((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-thio)(triethylphosphine)gold

Formula: C₂₀H₃₄AuO₉PS

Purezza: 98% (HPLC)

Peso molecolare: 678.48

Ref: IN-DG114846

Auranofine

CAS: 34031-32-8

Formula: C₂₀H₃₄AuO₉PS

Purezza: ≥ 95.0%

Colore e forma: White to off-white solid

Peso molecolare: 678.48

Ref: 7W-GP1600

Auranofin RS

CAS: 34031-32-8

Colore e forma: White Solid Crystalline Powder

Ref: 2K-103470002

Auranofin

CAS: 34031-32-8

Auranofin is a chrysotherapeutic agent which inhibits histamine release from human basophils. Auranofin is gold-containing salt extensively used in the treatment of rheumatoid arthritis. Auranofin has antimicrobial properties and inhibits the growth of Clostridium difficile more effectively than vancomycin and metronidazole. According to in vitro studies carried out in 2020, auranofin inhibits the replication of coronavirus SARS-CoV-2 and reduces inflammation in human cells.

Formula: C₂₀H₃₄AuO₉PS

Colore e forma: White Off-White Powder

Peso molecolare: 678.49 g/mol

Ref: 3D-MA05382

Auranofin-13C6

Prodotto controllato

CAS: 34031-32-8

Formula: C₁₄C₆H₃₄AuO₉PS

Colore e forma: Neat

Peso molecolare: 684.44

Ref: TR-A794752

Auranofin RS

CAS: 34031-32-8

Colore e forma: White Solid Crystalline Powder

Ref: 2K-1034700021