CAS 34381-68-5

Cloridrato di acebutololo

Descrizione:

Cloridrato di acebutololo è un antagonista selettivo dei recettori beta-1 adrenergici, utilizzato principalmente nel trattamento dell'ipertensione e di alcune condizioni cardiache. È caratterizzato dalla sua capacità di ridurre la frequenza cardiaca e la contrattilità miocardica, rendendolo efficace nella gestione dell'ipertensione e nella prevenzione dell'angina. Il composto è tipicamente somministrato per via orale ed è noto per la sua emivita relativamente lunga, che consente una somministrazione una o due volte al giorno. Cloridrato di acebutololo è una polvere cristallina bianca o bianco sporco, solubile in acqua e alcol, che facilita la sua formulazione in varie forme farmaceutiche. Il suo meccanismo d'azione implica il blocco dei recettori beta-1 nel cuore, portando a una diminuzione della gittata cardiaca e a una riduzione della pressione sanguigna. Inoltre, possiede un'attività simpaticomimetica intrinseca, il che significa che può stimolare parzialmente i recettori beta mentre li blocca, potenzialmente risultando in meno effetti collaterali rispetto ai beta-bloccanti non selettivi. Come per qualsiasi farmaco, è importante monitorare i potenziali effetti collaterali, inclusi bradicardia e affaticamento, e considerare le controindicazioni nei pazienti con determinate condizioni preesistenti.

Formula: C₁₈H₂₉ClN₂O₄

InChI: InChI=1/C18H28N2O4.ClH/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3;/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23);1H

InChI key: InChIKey=KTUFKADDDORSSI-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)C)O)C1=C(C(C)=O)C=C(NC(CCC)=O)C=C1.Cl

Sinonimi:

• (+-)-3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide monohydrochloride
• (1)-N-(3-Acetyl-4-(2-hydroxy-3-((isopropyl)amino)propoxy)phenyl)butyramide monohydrochloride
• 3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide hydrochloride
• 3-[2-acetyl-4-(butanoylamino)phenoxy]-2-hydroxy-N-(propan-2-yl)propan-1-aminium chloride
• <span class="text-smallcaps">DL</span>-1-(2-Acetyl-4-butyramido)-3-(isopropylamino)propan-2-ol hydrochloride
• <span class="text-smallcaps">DL</span>-1-(2-Acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride
• Acebutolol HCl
• Acebutolol hydrochloride [JAN]
• Acetanol
• Acetobutolol hydrochloride
• Butanamide, N-(3-acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-, monohydrochloride, (+-)-
• Butanamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-, hydrochloride (1:1)
• Butyranilide, 3'-acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)-, monohydrochloride, (+-)-
• Ccris 1102
• Diasectral
• Hsdb 6524
• Il 17803A
• M and B 17803A
• M&B 17,803A
• Neptall
• Sectral
• Unii-B025Y34C54
• Wesfalin
• dl-1-(2-Acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride
• ACEBUTOLOL HYDROCHLORIDE, IMPURITY IN-[3-ACETYL-4-[(2RS)-3-(ETHYLAMINO)-2-HYDROXYPROPOXY]PHENYL)BUTANAMIDE EP STANDARD
• N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide Hydrochloride
• n-[3-acetyl-4-[2-hydroxy-3-[(isopropyl)amino]propoxy]phenyl]butyramide hydrochloride
• ACEBUTOLOL HYDROCHLORIDE
• 3’-acetyl-4’-(2-hydroxy-3-(isopropylamino)propoxy)butyranilidehydrochloride
• (±)-N-[3-acetyl-4-[2-hydroxy-3-[(isopropyl)amino]propoxy]phenyl]butyramide monohydrochloride
• ACEBUTOLOL HYDROCHLORIDE, EP STANDARD
• acetobutololhydrochloride
• ACEBUTOLOL HYDROCHLORIDE, USP STANDARD
• Acecor
• 3’-acetyl-4’-(2-hydroxy-3-(isopropylamino)propoxy)-butyranilidmonohydrochl
• m&b17,803a
• ACEBUTOLOL HYDROCHLORIDE, IMPURITY CN-(3-ACETYL-4-HYDROXYPHENYL)BUTANAMIDE EP STANDARD
• dl-1-(2-acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropanehydroch
• N-[3-ACETYL-4-(2-HYDROXY-3-[ISOPROPYLAMINO]PROPOXY)PHENYL]-BUTANAMIDE HYDROCHLORIDE
• ACEBUTOLOL HYDROCHLORIDE, MM(CRM STANDARD)

Acebutolol Hydrochloride

CAS: 34381-68-5

Colore e forma: Off-White

Ref: 61-FOR0435.00

Acebutolol Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 34381-68-5

Colore e forma: Colourless

Ref: 61-AMP0435.00-01

ACEBUTOLOL HYDROCHLORIDE CRS

CAS: 34381-68-5

ACEBUTOLOL HYDROCHLORIDE CRS

Formula: C₉H₁₇NO

Colore e forma: White. Whitish. Crystalline Powder. Powder.

Peso molecolare: 155.2374

Ref: 41-A0040000

Acebutolol Hydrochloride

CAS: 34381-68-5

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Formula: C₁₈H₂₈N₂O₄·HCl

Colore e forma: White Off-White Powder

Peso molecolare: 372.89

Ref: 45-1000601

DL-1-(2-Acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride

CAS: 34381-68-5

Formula: C₁₈H₂₉ClN₂O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 372.8869

Ref: IN-DA007FXT

Acebutolol hydrochloride

CAS: 34381-68-5

Acebutolol HCl: cardioselective beta-blocker, minimal bronchial impact, intrinsic sympathomimetic, treats hypertension & ventricular arrhythmias.

Formula: C₁₈H₂₉ClN₂O₄

Purezza: 99.92% - >99.99%

Colore e forma: White Or Slightly Off-White Crystalline Powder Solid

Peso molecolare: 372.89

Ref: TM-T1012

Acebutolol-d7

CAS: 34381-68-5, 37517-30-9

Formula: C₁₈H₂₁D₇N₂O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 343.47

Ref: 4Z-A-169012

Acebutolol Hydrochloride

CAS: 34381-68-5

Colore e forma: Neat

Ref: 86-MM0435.00

Acebutolol hydrochloride

Prodotto controllato

CAS: 34381-68-5

Formula: C₁₈H₂₈N₂O₄·ClH

Colore e forma: Off-White

Peso molecolare: 372.89

Ref: 04-C10005150

Acebutolol Hydrochloride

CAS: 34381-68-5

Applications Cardioselective β-adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
References Cuthbert, O.A., et al.: Br. J. Pharmacol., 43, 639 (1971), Singh, B.N., et al.: Drugs, 29, 531 (1985), Foster, R.T., et al.: Anal. Profiles Drug Subs., 19, 1 (1990),

Formula: C₁₈H₂₉ClN₂O₄

Colore e forma: White to Pale Yellow Solid

Peso molecolare: 372.89

Ref: TR-A123800

Acebutolol hydrochloride

Prodotto controllato

CAS: 34381-68-5

Acebutolol is a non-selective beta-blocker that is used for the treatment of hypertension and other conditions. It inhibits the ryanodine receptor and prevents calcium release, which has been shown to be responsible for the contraction of cardiac muscle. Acebutolol also inhibits phosphodiesterase, which leads to increased levels of cyclic adenosine monophosphate (cAMP) in cells. In addition, acebutolol has been shown to inhibit the production of inflammatory mediators by inhibiting prostaglandin synthesis. The most common adverse effects include drowsiness, dizziness, fatigue, and headache. Acebutolol hydrochloride can be found in wastewater as a result of its use in humans and animals. This drug can be detected in wastewater using solid phase microextraction followed by gas chromatography/mass spectrometry (GC/MS).

Formula: C₁₈H₂₈N₂O₄•HCl

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 372.89 g/mol

Ref: 3D-FA16907

Acebutolol Hydrochloride

CAS: 34381-68-5

Formula: C₁₈H₂₈N₂O₄HCl

Peso molecolare: 336.4 : 36.46

Ref: ST-EA-CP-A94014