CAS 3599-32-4

Verde di indocianina

Descrizione:

Verde di indocianina (ICG) è un colorante sintetico utilizzato principalmente nella diagnostica medica, in particolare in oftalmologia e imaging cardiovascolare. È caratterizzato dal suo colore verde scuro e da una forte assorbimento nella regione dell'infrarosso vicino dello spettro elettromagnetico, rendendolo particolarmente utile per l'imaging a fluorescenza. La struttura chimica dell'ICG include uno scheletro di colorante cianina, che contribuisce alle sue uniche proprietà ottiche. L'ICG è solubile in acqua e ha un profilo di tossicità relativamente basso, il che ne aumenta l'idoneità per le applicazioni cliniche. Dopo la somministrazione, si lega alle proteine plasmatiche, consentendo una visualizzazione efficace del flusso sanguigno e della perfusione tissutale. La sua rapida eliminazione dal flusso sanguigno, principalmente attraverso il fegato, è un'altra caratteristica notevole. Inoltre, l'ICG è utilizzato in varie applicazioni oltre all'imaging, inclusa la valutazione della funzione epatica e la guida di procedure chirurgiche. In generale, le sue proprietà distintive rendono Verde di indocianina uno strumento prezioso sia in contesti diagnostici che terapeutici.

Formula: C₄₃H₄₇N₂NaO₆S₂

InChI: InChI=1/C43H48N2O6S2.Na/c1-42(2)36-26-24-32-18-10-12-20-34(32)40(36)44(28-14-16-30-52(46,47)48)38(42)22-8-6-5-7-9-23-39-43(3,4)37-27-25-33-19-11-13-21-35(33)41(37)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1/rC43H47N2NaO6S2/c1-42(2)36-26-24-32-18-10-12-20-34(32)40(36)44(28-14-16-30-53(47,48)49)38(42)22-8-6-5-7-9-23-39-43(3,4)37-27-25-33-19-11-13-21-35(33)41(37)45(39)29-15-17-31-54(50,51)52-46/h5-13,18-27H,14-17,28-31H2,1-4H3

InChI key: InChIKey=AANGVCDSLQANGQ-UHFFFAOYSA-N

SMILES: CC1(C)C2=C([N+](CCCCS(=O)(=O)[O-])=C1C=CC=CC=CC=C3N(CCCCS(=O)(=O)O)C4=C(C3(C)C)C=5C(C=C4)=CC=CC5)C=CC=6C2=CC=CC6.[Na]

Sinonimi:

• 1H-Benz[e]indolium, 2-[7-[1,1-dimethyl-3-(4-sulfobutyl)benz[e]indolin-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-, hydroxide, inner salt, sodium salt
• 1H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrien-1-yl]-1,1-dimethyl-3-(4-sulfobutyl)-, inner salt, sodium salt (1:1)
• 1H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-, hydroxide, inner salt, sodium salt
• 1H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-, inner salt, sodium salt
• 2-{7-[1,3-Dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]hepta-1,3,5-trienyl}-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz[e]indolium, hydroxyde, sel interne, sel de sodium
• 4,5-Benzoindotricarbocyanine
• 4-[(2Z)-2-[(2Z,4E,6Z)-7-[3,3-dimethyl-1-(4-sulfonatobutyl)benzo[g]indol-1-ium-2-yl]hepta-2,4,6-trienylidene]-3,3-dimethyl-benzo[g]indol-1-yl]butylsulfonyloxysodium
• Cardio Green
• HWD Indocyanine Green
• ICG
• Indocyanin green
• Ir-125
• Natrium-2-[7-[3,3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolin-2-yliden]hepta-1,3,5-trien-1-yl]-3,3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolinium
• Nk 2611
• Nk 2612
• Opthagreen
• Sacarosa, Bruta (De Cana)
• Saccharose, Brut (De Canne)
• So 270
• Sodium 2-(7-(3,3-Dimethyl-1-(4-Sulfonatobutyl)Benz(E)Indolin-2-Ylidene)Hepta-1,3,5-Trien-Y-1-Yl)-3,3-Dimethyl-1-(4-Sulfonatobutyl)Benz[E]Indolinium
• Sodium 2-(7-(3,3-dimethyl-1-(4-sulfonatobutyl)benz(e)indolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolinium
• Ujoviridin
• Wofaverdin
• sodium 4-(2-{7-[1,1-dimethyl-3-(4-sulfonatobutyl)-1H-benzo[e]indolium-2-yl]hepta-2,4,6-trien-1-ylidene}-1,1-dimethyl-1,2-dihydro-3H-benzo[e]indol-3-yl)butane-1-sulfonate
• 4-(2-[7-[1,1-DIMETHYL-3-(4-SULFO-BUTYL)-1H-BENZO[E]INDOL-2-YL]-HEPTA-2,4,6-TRIENYLIDENE]-1,1-DIMETHYL-BENZO[E]INDOLIUM-3-YL)-BUTANE-1-SULFONIC ACID SODIUM SALT
• )-1,3,5-heptatrienyl)-1,1-dimethyl-3-(4-sulfobutyl)-,hydroxide,innersalt,
• CARDIOGREEN
• BIS-[1-(4-SULFOBUTYL)-3,3-DIMETHYL-4,5-BENZOINDOLINYLIDEN-2]-HEPTAMETHINECYANINE-BETAINE-SODIUM SALT (INDOCYANINEGREEN, CARDIOGREEN)
• FOXGREEN
• IC GREEN
• INDOCYANINE GREEN
• ,innersalt,sodiumsalt(9ci)

Indocyanine Green

CAS: 3599-32-4

Synthetic organic coloring matter,nesoi

Formula: C₄₃H₄₇N₂NaO₆S₂

Colore e forma: Green Brown Blue Powder

Peso molecolare: 774.27732

Ref: 45-1340009

1H-Benz[e]indolium,2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-, inner salt, sodiumsalt

CAS: 3599-32-4

Formula: C₄₃H₄₇N₂NaO₆S₂

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 774.9629

Ref: IN-DA00I74W

Cardio-Green

CAS: 3599-32-4

Cardio-Green

Formula: C₄₃H₄₇N₂NaO₆S₂

Purezza: >97%

Colore e forma: Solid

Peso molecolare: 774.96

Ref: 54-OR1012625

Indocyanine Green

CAS: 3599-32-4

Formula: C₄₃H₄₇N₂O₆S₂·Na

Peso molecolare: 751.98 22.99

Ref: 4Z-I-134001

Cardiogreen, 95%, USP grade

CAS: 3599-32-4

Formula: C₄₃H₄₇N₂NaO₆S₂

Purezza: 90.0 - 105.0 % (dried basis)

Colore e forma: Dark green to brown crystalline powder

Peso molecolare: 774.96

Ref: 7W-GT1101

Indocyanine green

CAS: 3599-32-4

Indocyanine green

Formula: C₄₃H₄₇N₂NaO₆S₂

Purezza: ≥98%, 10 mM in DMSO

Peso molecolare: 774.96

Ref: 54-BUP17455

Indocyanine Green

CAS: 3599-32-4

Formula: C₄₃H₄₇N₂NaO₆S₂

Colore e forma: Light yellow to Amber to Dark green powder to crystal

Peso molecolare: 774.97

Ref: 3B-I0535

Indocyanine Green

CAS: 3599-32-4

Sodium 4-(2-(7-(1,1-dimethyl-3-(4-sulfonatobutyl)-1H-benzo[e]indol-2(3H)-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)butane-1-sulfonate

Formula: C₄₃H₄₇N₂NaO₆S₂

Purezza: 95%

Peso molecolare: 774.96

Ref: IN-DG134593

Indocyanine green

CAS: 3599-32-4

Indocyanine green (Cardiogreen) is a low toxicic fluorescent agent, is a tricarbocyanine dye,has been widely used in medical diagnostics.

Formula: C₄₃H₄₇N₂NaO₆S₂

Purezza: 98.77%

Colore e forma: Brown Solid

Peso molecolare: 774.96

Ref: TM-T14875

Indocyanine Green-d12

CAS: 3599-32-4

Formula: C₄₃H₃₅D₁₂N₂O₆S₂·Na

Peso molecolare: 764.05 22.99

Ref: 4Z-I-134002

Cardiogreen

CAS: 3599-32-4

Formula: C₄₃H₄₇N₂NaO₆S₂

Purezza: ≥ 90.0%

Colore e forma: Dark green powder

Peso molecolare: 774.96

Ref: 7W-GT1409

Indocyanine Green>d6

Prodotto controllato

CAS: 3599-32-4

Applications It is the labeled analogue of Indocyanine Green (I697000), a tricarbocyanine type of dye with infrared absorbing properties that can be used as a diagnostic aid (blood volume determination, cardiac output, hepatic function).
References Papageorgiou, P., et al.: Br. J. Dermatol., 142, 973 (2000), Dreno, B., et al.: Dermatology, 203, 135 (2001), Gollnick, H., et al.: Drugs, 63, 1579 (2003), Seaton, E., et al.: Lancet, 362, 1347 (2003),

Formula: C₇H₁₄N₂O

Colore e forma: Neat

Peso molecolare: NA

Ref: TR-I697003

Indocyanine green

CAS: 3599-32-4

Indocyanine green is a fluorescent dye with a variety of applications in medical imaging. It has been used to diagnose and evaluate the activity of cancer cells and brain functions. Indocyanine green has also been used as an angiographic agent for diagnosis of solid tumours. In addition, it can be used to evaluate liver function and the blood flow in the brain. The biological properties of indocyanine green have not yet been fully elucidated, but it is known that it binds to hepatocyte-like cells in culture and is found at high levels in human serum. This dye shows fluorescence when bound to DNA or RNA, which indicates its possible use as a molecular probe for detecting carcinoma cells. 
Indocyanine green is a STT3B inhibitor and has been shown to prevent α-amanitin toxicity in mice (Wang et al, 2023). This means it could be a possible antidote to poisoning by Amanita, such as death cap mushroom Amanita phalloides, which is the cause of over 90% of fatal mushroom poisoning.

Formula: C₄₃H₄₇N₂O₆S₂·Na

Purezza: (%) Min. 95%

Colore e forma: Green Powder

Peso molecolare: 774.96 g/mol

Ref: 3D-FI10558

Indocyanine green

CAS: 3599-32-4

Purezza: 95%

Peso molecolare: 774.97

Ref: 10-F868901

Indocyanine Green (~90%)

Prodotto controllato

CAS: 3599-32-4

Formula: C₄₃H₄₇N₂O₆S₂·Na

Purezza: ~90%

Colore e forma: Neat

Peso molecolare: 774.96

Ref: TR-I697000

Indocianine Green RS

CAS: 3599-32-4, 7681-82-5

Colore e forma: Dark Greenish Blue Solid Powder

Ref: 2K-2001000021