CAS 366789-02-8
:Rivaroxaban
Descrizione:
Rivaroxaban è un farmaco anticoagulante orale utilizzato principalmente per la prevenzione e il trattamento dei disturbi tromboembolici, come la trombosi venosa profonda e l'embolia polmonare. Funziona come un inibitore diretto del fattore Xa, che interrompe la cascata di coagulazione e riduce la formazione di coaguli di sangue. Rivaroxaban è caratterizzato dalla sua alta biodisponibilità e farmacocinetica prevedibile, consentendo una posologia fissa senza la necessità di monitoraggio routinario dei parametri di coagulazione. La sostanza viene tipicamente somministrata in forma di compressa ed è assorbita rapidamente, con concentrazioni plasmatiche massime che si verificano entro poche ore dopo l'ingestione. Viene metabolizzata principalmente nel fegato attraverso gli enzimi del citocromo P450 ed è escreta attraverso vie renali e fecali. Gli effetti collaterali comuni possono includere complicazioni emorragiche, il che richiede cautela nei pazienti con determinati fattori di rischio. Il profilo di efficacia e sicurezza di Rivaroxaban lo ha reso un'opzione ampiamente utilizzata nella terapia anticoagulante, sebbene sia controindicato nei pazienti con emorragia attiva o grave compromissione renale.
Formula:C19H18ClN3O5S
InChI:InChI=1/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
InChI key:InChIKey=KGFYHTZWPPHNLQ-AWEZNQCLSA-N
SMILES:O=C1N(C[C@H](CNC(=O)C=2SC(Cl)=CC2)O1)C3=CC=C(C=C3)N4C(=O)COCC4
Sinonimi:- (S)-Rivaroxaban
- 2-Thiophenecarboxamide, 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-
- 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
- 5-Chloro-N-([(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl]-methyl)-2-thiophenecarboxamide
- 5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
- 5-Chloro-N-[[(S)-3-(4-(3-oxomorpholin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]-thiophene-2-carboxamide
- 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl]thiophene-2-carboxamide
- Bay 59-7939
- Rivaroxaban intermediates
- Rivaroxban
- Xarelto
- Rivaroxaban
- (S)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
- Rivaroxaban API
- Rivarobaxan
- Rivaroxaban(Xarelto)
- (S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carboxami
- Rivaroxaba
- Vedi altri sinonimi
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Rivaroxaban
CAS:Formula:C19H18ClN3O5SPurezza:>98.0%(HPLC)(T)Colore e forma:White to Light yellow powder to crystalPeso molecolare:435.88Rivaroxaban
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C19H18ClN3O5SColore e forma:White PowderPeso molecolare:435.06557Rivaroxaban
CAS:RivaroxabanFormula:C19H18ClN3O5SPurezza:99.50%Colore e forma:SolidPeso molecolare:435.88Rivaroxaban
CAS:Rivaroxaban (BAY 59-7939) is an oral, direct factor Xa inhibitor with anticoagulant properties, interfering with thrombin formation.Formula:C19H18ClN3O5SPurezza:99.93% - >99.99%Colore e forma:White SolidPeso molecolare:435.88Rivaroxaban
CAS:Formula:C19H18ClN3O5SPurezza:≥ 98.0% (dried basis)Colore e forma:White to off-white powderPeso molecolare:435.88Rivaroxaban (Standard)
CAS:Rivaroxaban (Standard) is a reference standard for research and analysis in studies involving Rivaroxaban. Rivaroxaban (BAY 59-7939) is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both free factor Xa and factor Xa bound in the prothrombinase complex. This interferes with the conversion of prothrombin (factor II) to thrombin and eventually prevents the formation of cross-linked fibrin clots. Rivaroxaban does not affect existing thrombin levels.Formula:C19H18ClN3O5SPeso molecolare:435.88Rivaroxaban
CAS:Applications A novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.
References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),Formula:C19H18ClN3O5SColore e forma:NeatPeso molecolare:435.88(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
CAS:(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamideFormula:C19H18ClN3O5SPurezza:98%Peso molecolare:435.88Rivaroxaban - Bio-X ™
CAS:Rivaroxaban is a natural drug that is a direct factor Xa inhibitor. It has been shown to be an effective therapy for the treatment of atrial fibrillation, deep vein thrombosis (DVT) and pulmonary embolism (PE). It works by inhibiting the enzyme, thrombin, which is responsible for the formation of blood clots. Rivaroxaban also has an effect on the coagulation system by decreasing the levels of fibrinogen and increases in antithrombin III. This drug does not have any specific antidote, but it can be reversed with heparin. Pharmacodynamics and drug interactions have been studied extensively in preclinical models, demonstrated by the concentration–time curves.Formula:C19H18ClN3O5SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:435.88 g/mol5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide
CAS:Formula:C19H18ClN3O5SPurezza:99%Colore e forma:SolidPeso molecolare:435.8813Rivaroxaban
CAS:Rivaroxaban is a natural drug that is a direct factor Xa inhibitor. It has been shown to be an effective therapy for the treatment of atrial fibrillation, deep vein thrombosis (DVT) and pulmonary embolism (PE). It works by inhibiting the enzyme, thrombin, which is responsible for the formation of blood clots. Rivaroxaban also has an effect on the coagulation system by decreasing the levels of fibrinogen and increases in antithrombin III. This drug does not have any specific antidote, but it can be reversed with heparin. Pharmacodynamics and drug interactions have been studied extensively in preclinical models, demonstrated by the concentration–time curves.
Formula:C19H18ClN3O5SPurezza:Min. 98 Area-%Colore e forma:White Off-White PowderPeso molecolare:435.88 g/mol
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