CAS 388082-77-7

ditosilato di lapatinib

Descrizione:

ditosilato di lapatinib è un inibitore della tirosina chinasi a piccole molecole utilizzato principalmente nel trattamento di alcuni tipi di cancro al seno, in particolare quelli che sono positivi per HER2. Funziona inibendo l'attività del recettore del fattore di crescita epidermico (EGFR) e HER2, che sono coinvolti nella proliferazione e sopravvivenza delle cellule tumorali. Il composto è caratterizzato dalla sua formula molecolare, che riflette la sua struttura complessa, inclusi un gruppo dicloroanilina e un gruppo solfonato che ne migliora la solubilità. ditosilato di lapatinib è tipicamente somministrato per via orale ed è noto per la sua capacità di penetrare la barriera ematoencefalica, rendendolo un'opzione potenziale per il trattamento delle metastasi cerebrali. La sua farmacocinetica include un'assorbimento moderato e una emivita che consente una somministrazione una volta al giorno. Gli effetti collaterali comuni possono includere diarrea, eruzione cutanea e nausea. Come per qualsiasi terapia mirata, il suo uso è spesso accompagnato da monitoraggio dell'efficacia e delle reazioni avverse, sottolineando l'importanza della medicina personalizzata in oncologia.

Formula: C₄₃H₄₂ClFN₄O₁₀S₃

InChI: InChI=1/C29H26ClFN4O4S.2C6H6O3S.H2O/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*7-10(8,9)6-4-2-1-3-5-6;/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*1-5H,(H,7,8,9);1H2

InChI key: InChIKey=OZDXXJABMOYNGY-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=CC(=C2)C=3OC(CNCCS(C)(=O)=O)=CC3)N=CN1)C4=CC(Cl)=C(OCC5=CC(F)=CC=C5)C=C4.S(=O)(=O)(O)C1=CC=C(C)C=C1

Sinonimi:

• 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, 4-methylbenzenesulfonate (1:2)
• 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, bis(4-methylbenzenesulfonate)
• Benzenesulfonic Acid
• Gw 572016F
• Hydrate
• Lapatinib Ditoyslate
• Lapatinib ditosylate anhydrous
• Lapatinib, Tykerb, GW572016
• N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate)
• N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6 -[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine h ydrate
• N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
• N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine benzenesulfonate hydrate (1:2:1)
• N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylbenzenesulfonate)
• Tykerb
• Tykerb N-{3-Chloro-4-[(3-fluorophenyl)-methoxy]-phenyl}-6-{5-{(2-methylsulfonylethy amino)-methyl]-2-furyl}-quinazolin-4-amine-benzenesulfonic acid
• Lapatinib ditosylate
• GW-572016 ditosylate
• Lapatinib (GW-572016) Ditosylate
• GW 572016 ditosylate
• N-{3-chloro-4-[(3-fluorobenzyl)oxyl]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylBenzenesulfonate)
• Lapatinib Ditosylate (Tykerb)
• N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(Methylsulfonyl)ethyl]aMino}Methyl)-2-furyl]-4-quinazolinaMine 4-Methylbenzenesulfonate (1:2)
• GW-572016F Ditosylate
• Tykerb Ditosylat
• Lapatinib ditasylate
• N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4-amine,di4-methylbenzenesulfonate
• Tykerb(lapatinib)
• Tykerb Ditosylate

Lapatinib Ditosylate

CAS: 388082-77-7

Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).

Formula: C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S

Purezza: 99.41%

Colore e forma: Yellow Solid

Peso molecolare: 925.46

Ref: TM-T6235

Lapatinib ditosylate

CAS: 388082-77-7

Formula: C₄₃H₄₂ClFN₄O₁₀S₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 925.4608

Ref: IN-DA00C6B6

Lapatinib Ditosylate

CAS: 388082-77-7

Lapatinib Ditosylate

Purezza: ≥98%

Peso molecolare: 925.46g/mol

Ref: 54-BUP15047

Lapatinib Ditosylate

CAS: 388082-77-7

Formula: C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S

Colore e forma: Yellow Solid

Peso molecolare: 581.06 2*172.20

Ref: 4Z-L-255

Lapatinib-d4 Ditosylate

CAS: 388082-77-7

Formula: C₂₉H₂₂D₄ClFN₄O₄S·2C₇H₈O₃S

Colore e forma: Light Yellow Solid

Peso molecolare: 585.08 2 172.20

Ref: 4Z-L-253

N-(3-Chloro-4-((3-Fluorobenzyl)Oxy)Phenyl)-6-(5-(((2-(Methylsulfonyl)Ethyl)Amino)Methyl)Furan-2-Yl)Quinazolin-4-Amine Bis(4-Methylbenzenesulfonate)

CAS: 388082-77-7

N-(3-Chloro-4-((3-Fluorobenzyl)Oxy)Phenyl)-6-(5-(((2-(Methylsulfonyl)Ethyl)Amino)Methyl)Furan-2-Yl)Quinazolin-4-Amine Bis(4-Methylbenzenesulfonate)

Purezza: 98%

Peso molecolare: 925.46g/mol

Ref: 54-PC109179

Lapatinib Ditosylate

CAS: 388082-77-7

Formula: C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 925.46

Ref: 3B-L0467

Lapatinib Ditosylate

Prodotto controllato

CAS: 388082-77-7

Applications Reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.
References Kim, T.E., et al.: Drugs, 6, 886 (2003), Wood, E.R., et al.: Cancer Res., 64, 6652 (2004), Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005),

Formula: C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S

Colore e forma: Yellow

Peso molecolare: 925.46

Ref: TR-L175800

Lapatinib tosylate anhydrous

CAS: 388082-77-7

Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface.

Formula: C₂₉H₂₆ClFN₄O₄S•(C₇H₈O₃S)₂

Purezza: Min. 95%

Colore e forma: Off-White Powder

Peso molecolare: 925.46 g/mol

Ref: 3D-FL65053