CAS 38819-10-2

2-ammino-9-(beta-D-arabinofuranosil)-3,9-diidro-6H-purina-6-one

Descrizione:

2-ammino-9-(beta-D-arabinofuranosil)-3,9-diidro-6H-purina-6-one, comunemente noto come Ara-A o arabinosiladenina, è un analogo di nucleoside con notevoli proprietà antivirali. È caratterizzato dalla sua struttura di base purinica, che include un gruppo amminico in posizione 2 e un moiety di zucchero beta-D-arabinofuranosilico. Questo composto presenta una stereochimica unica che contribuisce alla sua attività biologica, in particolare nell'inibire la replicazione virale. Ara-A è principalmente utilizzato nel trattamento delle infezioni virali, comprese quelle causate dal virus dell'herpes simplex e altri virus a RNA. Il suo meccanismo d'azione implica l'interferenza con la sintesi degli acidi nucleici virali, rendendolo un agente terapeutico prezioso. Il composto è tipicamente somministrato nella sua forma fosfato per migliorare la solubilità e la biodisponibilità. Inoltre, Ara-A è stato studiato per il suo potenziale nella terapia del cancro grazie alla sua capacità di interrompere i processi cellulari. In generale, le sue caratteristiche strutturali e le attività biologiche lo rendono un composto significativo nella chimica medicinale e nella virologia.

Formula: C₁₀H₁₃N₅O₅

InChI: InChI=1/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6+,9-/m1/s1

InChI key: InChIKey=NYHBQMYGNKIUIF-FJFJXFQQSA-N

SMILES: O=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)NC(N)=N1

Sinonimi:

• 1-β-D-Arabinofuranosylguanine
• 2-Amino-6-hydroxy-9-(β-<span class="text-smallcaps">D</span>-arabinofuranosyl)purine
• 2-Amino-9-(beta-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one
• 2-Amino-9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-1,9-dihydro-6H-purin-6-one
• 6H-Purin-6-one, 2-amino-9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-1,9-dihydro-
• 6H-purin-6-one, 2-amino-9-beta-D-arabinofuranosyl-1,9-dihydro-
• 9-(Beta-D-Arabinofuranosyl)Guanine
• 9-Arabinoguanine
• 9-β-<span class="text-smallcaps">D</span>-Arabinofuranosylguanine
• A 4233
• Arabinoguanosine
• Araguanosine
• Guanine arabinoside
• Guanine, 9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• NSC 76352
• ara-Guanosine
• Arabinosylguanine
• 9-β-D-Arabinofuranosylguanine
• Guanine, 9-β-D-arabinofuranosyl-
• 2-Amino-6-hydroxy-9-(β-D-arabinofuranosyl)purine
• 6H-Purin-6-one, 2-amino-9-β-D-arabinofuranosyl-1,9-dihydro-
• 2-Amino-9-β-D-arabinofuranosyl-1,9-dihydro-6H-purin-6-one
• )-21-(Acetyloxy)-9,11-epoxy-6-fluoro-16-methyl-d3-pregna-1,4-diene-3,20-dione
• )-10-Bromo-8,9,10,11-tetrahydrobenz[a]anthracene-8,9,11-triol
• 9-beta-D-Arabinofuranosylguanine Hydrate
• GUANINE-9-ARABINOSIDE
• -Epoxy-21dehydroxy Betamethasone
• Ara-G
• 9-β-D-Arabinofuranosyl-1,6-dihydro-2-amino-6-oxo-9H-purine
• 9-beta-Arabinosylguanine
• )-9,11-Epoxy-pregna-1,4,16-triene-3,20-dione
• 9-(β-D-Arabinoribofuranosyl)-guanine
• 9-arabinofuranosylguanine
• 9-(BETA-D-ARABINOFURANOSYL)GUANINE USP/EP/BP
• 9-(b-D-Arabinofuranosyl)guanine
• 9-β-D-Arabinofuranosyl-2-amino-9H-purin-6-ol
• )-9,11-Epoxy-6-fluoro-21-hydroxy-16-methyl-pregna-1,4-diene-3,20-dione
• 9-β-D-Arabinofuranosylguanine Hydrate
• 2-AMino-9-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
• )-21-(Acetyloxy)-9,11-epoxy-6-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione
• -Epoxy-17,21-dihydroxy-16&beta
• 2-amino-9-beta-d-arabinofuranosyl-1,9-dihydro-6h-purin-6-on
• Guanine, 9-(beta-D-arabinofuranosyl)-
• 9-β-D-Arabinofuranosylguanine Hydrate &gt
• 9-&beta
• 9-(beta-d-arabinofuranosyl)-guanin
• )-9,11-Epoxy-1,21-dihydroxy-4,16-dimethyl-19-norpregna-1,3,5(10)-trien-20-one
• 9-(β-D-Arabinofuranosyl)guanine ,97%
• )-9,11-Epoxy-21-hydroxy-16-methyl-pregna-1,4-diene-3,20-dione
• )-21-(Acetyloxy)-9,11-epoxypregna-1,4,16-triene-3,20-dione
• 2-Amino-9-β-D-arabinofuranosyl-9H-purine-6(1H)-one
• Ara-G hydrate, 98%, inhibitor of DNA synthesis, an antimetabolite and antineoplastic.
• Ara-G hydrate
• -Arabinofuranosylguanine Hydrate
• 2-amino-9-(beta-D-arabinofuranosyl)-3,9-dihydro-6H-purin-6-one
• ARABINOFURANOSYL-GUANINE
• D
• -
• )-9-Bromo-8,9,10,11-tetrahydrobenz[a]anthracene-8,10,11-triol-d9
• Arabinofuranosyl-guanine (ara-G)
• )-21-(Acetyloxy)-9,11-epoxy-6-fluoro-pregna-1,4,16-triene-3,20-dione
• 9-β-D-Arabinofuranosyl guanine hydrate
• -methyl-pregn-4-ene-3,20-dione
• )-9,11-Epoxy-6-fluoropregna-1,4,16-triene-3,20-dione
• ARA-G 9-(BETA-D-ARABINOFURANOSYL)-GUANINE

9-beta-D-Arabinofuranosylguanine

CAS: 38819-10-2

Formula: C₁₀H₁₃N₅O₅

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 283.24

Ref: 3B-A2739

9-β-Arabinosylguanine

CAS: 38819-10-2

9-β-Arabinosylguanine

Formula: C₁₀H₁₃N₅O₅

Purezza: 98%

Peso molecolare: 283.24

Ref: 54-OR1026312

Ara-G

CAS: 38819-10-2

Ara-G

Formula: C₁₀H₁₃N₅O₅

Purezza: 98.5%

Peso molecolare: 283.24

Ref: 54-BUP16058

9-β-D-Arabinofuranosylguanine

CAS: 38819-10-2

Formula: C₁₀H₁₃N₅O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 283.2407

Ref: IN-DA0037XI

9-β-D-Arabinofuranosylguanine

CAS: 38819-10-2

9-beta-Arabinosylguanine

Formula: C₁₀H₁₃N₅O₅

Purezza: 98%

Peso molecolare: 283.24

Ref: IN-DG12134

Ara-G

CAS: 38819-10-2

Ara-G, a deoxyguanosine analog, inhibits DNA synthesis, targeting T cell leukemia by converting to araGTP.

Formula: C₁₀H₁₃N₅O₅

Purezza: 98.74%

Colore e forma: White Solid

Peso molecolare: 283.2407

Ref: TM-T36944

Nelarabine Impurity 16

CAS: 38819-10-2

Formula: C₁₀H₁₃N₅O₅

Peso molecolare: 283.24

Ref: 4Z-N-5217

9-(b-D-Arabinofuranosyl)guanine

CAS: 38819-10-2

Formula: C₁₀H₁₃N₅O₅·xH₂O

Purezza: ≥ 97.5%

Colore e forma: White to off-white crystalline powder

Peso molecolare: 283.24 (anhydrous)

Ref: 7W-GN2070

9-(b-D-Arabinofuranosyl)guanine

CAS: 38819-10-2

9-(b-D-Arabinofuranosyl)guanine is an arabinoside derivative that has high affinity for DNA. 9-(b-D-Arabinofuranosyl)guanine binds to the phosphate groups in DNA and inhibits the synthesis of DNA. It is used in vitro assays to study molecular pathogenesis and in vivo as a drug against leukemia, lymphomas, and other cancers. 9-(b-D-Arabinofuranosyl)guanine also inhibits protein synthesis by binding to ribosomes. This drug can cause significant side effects such as gastrointestinal distress, diarrhea, nausea, vomiting, and abdominal pain. It can also cause blood dyscrasias and liver damage.

Formula: C₁₀H₁₃N₅O₅

Purezza: Min. 97 Area-%

Colore e forma: White Powder

Peso molecolare: 283.24 g/mol

Ref: 3D-NA06002

Ara-G

CAS: 38819-10-2

Formula: C₁₀H₁₃N₅O₅

Peso molecolare: 283.24

Ref: BE-RMCN045008

9-β-D-Arabinofuranosylguanine

CAS: 38819-10-2

Purezza: 98%

Peso molecolare: 283.092

Ref: 10-F858517

9-b-D-Arabinofuranosylguanine

CAS: 38819-10-2

Formula: C₁₀H₁₃N₅O₅

Purezza: 95.0%

Colore e forma: Liquid, No data available.

Peso molecolare: 283.244

Ref: 10-F225628

Ara-G

Prodotto controllato

CAS: 38819-10-2

Applications Ara-G is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic.

Formula: C₁₀H₁₃N₅O₅

Colore e forma: Neat

Peso molecolare: 283.24

Ref: TR-A765558

Ara-G-13C,15N2

Prodotto controllato

CAS: 38819-10-2

Formula: CC₉H₁₃₁₅N₂N₃O₅

Colore e forma: Neat

Peso molecolare: 286.22

Ref: TR-A765559

Nelarabine Impurity 16

CAS: 38819-10-2

Formula: C₁₀H₁₃N₅O₅

Peso molecolare: 283.24

Ref: ST-EA-CP-N38018

9-(b-D-Arabinofuranosyl)guanine

CAS: 38819-10-2

Formula: C₁₀H₁₃N₅O₅

Peso molecolare: 283.24

Ref: ST-EA-CP-A88013

9-(b-D-Arabinofuranosyl)guanine - Bio-X ™

CAS: 38819-10-2

9-(b-D-Arabinofuranosyl) guanine is a purine nucleoside in which guanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. 9-(b-D-Arabinofuranosyl) guanine binds to the phosphate groups in DNA and inhibits the synthesis of DNA causing cell death. It also has antineoplastic properties.

Formula: C₁₀H₁₃N₅O₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 283.24 g/mol

Ref: 3D-BA300152