CAS 4004-05-1

1,2-Dioleil-sn-glicero-3-fosfoetanolamina

Descrizione:

1,2-Dioleil-sn-glicero-3-fosfoetanolamina (DOPE) è un fosfolipide comunemente usato in biochimica e biologia molecolare. È caratterizzato dalle sue catene di acidi grassi oleoyl duali, che contribuiscono alla sua natura anfifilica, permettendogli di formare doppi strati lipidici e vescicole in ambienti acquosi. La molecola è composta da uno scheletro di glicerolo, due catene oleoyl e un gruppo testa di fosfoetanolamina, che conferisce una carica netta neutra a pH fisiologico. Il DOPE è noto per la sua capacità di facilitare la fusione delle membrane ed è spesso utilizzato nei sistemi di somministrazione di farmaci, in particolare per l'incapsulamento di acidi nucleici e proteine. La sua fluidità e la capacità di adottare varie conformazioni lo rendono un componente prezioso nelle formulazioni liposomiali. Inoltre, il DOPE può migliorare la stabilità e l'efficacia di vaccini e terapie geniche. La sostanza è tipicamente conservata in condizioni controllate per mantenere la sua integrità ed è solubile in solventi organici, rendendola adatta per varie applicazioni di laboratorio.

Formula: C₄₁H₇₈NO₈P

InChI: InChI=1/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1

InChI key: InChIKey=MWRBNPKJOOWZPW-NYVOMTAGSA-N

SMILES: [C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)(COC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCCN)(=O)O

Sinonimi:

• (2R)-3-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-[(9Z)-octadec-9-enoyloxy]propyl (9Z)-octadec-9-enoate
• 1,2-Di(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
• 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
• 1,2-Dioleoyl-sn-glycero-3-phosphorylethanolamine
• 9-Octadecenoic acid (9Z)-, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
• 9-Octadecenoic acid (9Z)-, 1,1′-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester
• 9-Octadecenoic acid (Z)-, 1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester, (R)-
• <span class="text-smallcaps">L</span>-α-Dioleoylphosphatidylethanolamine
• Coatsome MC 8181
• Coatsome ME 8181
• Dioleoyl phosphoethanolamine
• Dioleoyl-<span class="text-smallcaps">L</span>-α-phosphatidylethanolamine
• Dioleoylphosphatidylethanolamine
• Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1,2-diolein, <span class="text-smallcaps">L</span>-
• L-A-phosphatidylethanolamine dioleoyl
• Olein, 1,2-di-, 2-aminoethyl hydrogen phosphate, <span class="text-smallcaps">L</span>-
• Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1,2-diolein, L-
• Olein, 1,2-di-, 2-aminoethyl hydrogen phosphate, L-
• 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, >99%
• (9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
• 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHO-ETHA-N OLAMINE, 10 MG/ML
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE
• 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE)
• 1,2-Dioleoyl-sn-glycero-3-PE
• sn
• PE(18:1(9Z)/18:1(9Z))
• 18:1 PE
• 3-SN-PHOSPHATIDYLETHANOLAMINE, 1,2-DIDEOYL
• O-(1-O,2-O-Dioleoyl-L-glycero-3-phospho)-2-aminoethanol
• 18:1 (Delta9-Cis) PE (DOPE)
• 2-Aminoethyl (R)-2,3-bis(oleoyloxy)propyl hydrogen phosphate
• 1,2-Dioleoyl-
• dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)
• 1,2-Dioleoyl-3-sn-phosphatidylethanolamine
• L-β,γ-Dioleoyl-α-cephalin
• L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL
• L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL (C18:1,[CIS]-9)
• DOPE
• L-BETA,GAMMA-DIOLEOYL-ALPHA-CEPHALIN
• (+)-1-O,2-O-Dioleoyl-L-glycerol 3-(phosphoric acid 2-aminoethyl) ester
• Phosphoric acid hydrogen (2-aminoethyl)[(2R)-2,3-bis(oleoyloxy)propyl] ester
• L-A-PHOSPHATIDYLETHANOLAMINE, DIOLEO
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine≥ 98% (HPTLC)
• DIOLEOYL PHOSPHATIDYL ETHANOLAMINE
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 98+%
• 3-sn-Phosphatidylethanolamine, 1,2-dideoyl, L-β,γ-Dioleoyl-α-cephalin, DOPE
• COATSOME ME-8181 (DOPE)
• -glycero-3-phosphoethanolamine

DOPE

CAS: 4004-05-1

(Z)-(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dioleate

Formula: C₄₁H₇₈NO₈P

Purezza: 98%

Peso molecolare: 744.03

Ref: IN-DG53396

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)

CAS: 4004-05-1

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)

Formula: C₄₁H₇₈NO₈P

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 744.03368

Ref: 54-OR54392

9-Octadecenoic acid (9Z)-,(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediylester

CAS: 4004-05-1

Formula: C₄₁H₇₈NO₈P

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 744.0337

Ref: IN-DA00IMFR

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)

CAS: 4004-05-1

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)

Formula: C₄₁H₇₈NO₈P

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 744.03

Ref: 54-BI12158

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)

CAS: 4004-05-1

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)

Formula: C₄₁H₇₈NO₈P

Purezza: ≥95%

Colore e forma: Solid

Peso molecolare: 744.03

Ref: 54-BUP17310

1,2-Dioleoyl-d62-sn-glycero-3-Phosphatidylethanolamine

CAS: 4004-05-1

Formula: C41H16D62NO8P

Purezza: >98%

Colore e forma: Solid

Peso molecolare: 806.43

Ref: 48-71-5718

1,2-Dioleoyl-sn-Glycero-3-Phosphatidylethanolamine

CAS: 4004-05-1

Formula: C41H78NO8P

Purezza: >98%

Colore e forma: Solid

Peso molecolare: 744.04

Ref: 48-37-1821

DOPE

CAS: 4004-05-1

DOPE, a neutral lipid, boosts cationic liposome efficiency in non-viral gene delivery.

Formula: C₄₁H₇₈NO₈P

Purezza: 97.23% - ≥98%

Colore e forma: Lyophilized Powder

Peso molecolare: 744.03

Ref: TM-T19080

DOPE (1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine)

CAS: 4004-05-1

Formula: C₄₁H₇₈NO₈P

Peso molecolare: 744.05

Ref: 4Z-F-106056

1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE)

Prodotto controllato

CAS: 4004-05-1

Applications 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
References Misra, S.K., et al.: PLoS One, 8, e68305 (2013); MacDonald, R., et al.: J. Pharm. Sci., 88, 896 (1999); Chen, Y., et al.: Int. J. Nanomedicine, 8, 1573 (2013)

Formula: C₄₁H₇₈NO₈P

Colore e forma: Neat

Peso molecolare: 744.034

Ref: TR-D482210

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

M01678 - 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

Formula: C₄₁H₇₈NO₈P

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 744.048

Ref: 10-M01678

1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine-d4

Prodotto controllato

CAS: 4004-05-1

Formula: C₄₁D₄H₇₄NO₈P

Colore e forma: Neat

Peso molecolare: 748.058

Ref: TR-D482212

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a synthetic lipid that has been extensively studied for its ability to form liposomes and other lipid bilayers. DOPE is used as a model system for studying the phase transition temperature of phospholipid membranes. DOPE has also been shown to be effective in the transfection of cells with plasmids and other DNA molecules. DOPE is cationic, which allows it to interact with anionic membrane proteins and facilitate their insertion into the membrane. This facilitates the formation of multilamellar vesicles, which are necessary for vesicle budding and fusion.

Formula: C₄₁H₇₈NO₈P

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 744.03 g/mol

Ref: 3D-FD148481

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS: 4004-05-1

Formula: C₄₁H₇₈NO₈P

Purezza: >98.0%(T)

Colore e forma: White to Light yellow powder to lump

Peso molecolare: 744.05

Ref: 3B-D4251