CAS 42553-65-1

Crocin

Descrizione:

Crocin è un pigmento carotenoide derivato principalmente dalla pianta di zafferano, Crocus sativus. È noto per il suo vibrante colore giallo-arancio ed è responsabile della tonalità caratteristica dello zafferano. Chimicamente, Crocin è un derivato glicosilato della crocetina, composto da uno scheletro di acido dicarbossilico con più moieties di zucchero attaccate, che ne migliora la solubilità in acqua. Crocin mostra varie attività biologiche, inclusi effetti antiossidanti, antinfiammatori e potenziali effetti neuroprotettivi, rendendolo di interesse sia nell'industria alimentare che in quella farmaceutica. Viene spesso studiato per le sue potenziali applicazioni terapeutiche, in particolare nel contesto delle malattie neurodegenerative e dei disturbi dell'umore. Inoltre, Crocin è riconosciuto per il suo ruolo come colorante naturale nei prodotti alimentari, fornendo un'alternativa sicura ai coloranti sintetici. La sua stabilità e biodisponibilità sono fattori importanti nella sua applicazione, e la ricerca in corso continua a esplorare il suo ampio spettro di benefici e usi per la salute.

Formula: C₄₄H₆₄O₂₄

InChI: InChI=1S/C44H64O24/c1-19(11-7-13-21(3)39(59)67-43-37(57)33(53)29(49)25(65-43)17-61-41-35(55)31(51)27(47)23(15-45)63-41)9-5-6-10-20(2)12-8-14-22(4)40(60)68-44-38(58)34(54)30(50)26(66-44)18-62-42-36(56)32(52)28(48)24(16-46)64-42/h5-14,23-38,41-58H,15-18H2,1-4H3/b6-5+,11-7+,12-8+,19-9+,20-10+,21-13+,22-14+/t23-,24-,25-,26-,27-,28-,29-,30-,31+,32+,33+,34+,35-,36-,37-,38-,41-,42-,43+,44+/m1/s1

InChI key: InChIKey=SEBIKDIMAPSUBY-RTJKDTQDSA-N

SMILES: C(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]2O[C@@H](OC(/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C(O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)=O)\C)\C)/C)/C)=O)[C@H](O)[C@@H](O)[C@@H]2O

Sinonimi:

• 6-O-β-D-glucopyranosyl-1-O-[(2E,4E,6E,8E,10Z,12E,14Z)-16-{[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]methyl}-2,6,11,15-tetramethylheptadeca-2,4,6,8,10,12,14,16-octaenoyl]-β-D-glucopyranose
• 8,8′-Diapo-ψ,ψ-carotenedioic acid, bis(6-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-glucopyranosyl) ester
• Crocetin bis(gentiobiosyl) ester
• Crocetin di(β-<span class="text-smallcaps">D</span>-gentiobiosyl) ester
• Crocetin di-β-gentiobiosyl ester
• Crocetin digentiobioside
• Crocin
• Crocin (gardenia fruit
• Crocin 1
• Crocin 4
• Crocin A
• Kiriyasu Oil Yellow GY
• Saffron
• Saffron (Natural)
• Trans-crocin-1
• all-trans-Crocetin di-β-<span class="text-smallcaps">D</span>-gentiobiosyl ester
• bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate (non-preferred name)
• trans-Crocetin di(β-<span class="text-smallcaps">D</span>-gentiobiosyl) ester
• α-Crocin
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranose, 6-O-β-<smallcap>D</span>-glucopyranosyl-, 1,1′-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]
• 8,8′-Diapo-ψ,ψ-carotenedioic acid, bis(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) ester

Crocin (Gardenia Fruits Extract)

CAS: 42553-65-1

Formula: C₄₄H₆₄O₂₄

Purezza: multi component mixture(HPLC)

Colore e forma: Light yellow to Brown powder to crystal

Peso molecolare: 976.97

Ref: 3B-C1527

Crocin

CAS: 42553-65-1

Crocin

Formula: C₄₄H₆₄O₂₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 976.97

Ref: 54-OR1026433

Crocin

CAS: 42553-65-1

Crocin: a water-soluble carotenoid in saffron, used for flavoring, coloring, and in Chinese medicine; inhibits TNF-alpha-induced apoptosis in cells.

Formula: C₄₄H₆₄O₂₄

Purezza: 98.13% - 99.74%

Colore e forma: Red Solid

Peso molecolare: 976.9646

Ref: TM-T2823

Crocin

CAS: 42553-65-1

Crocin

Formula: C₄₄H₆₄O₂₄

Purezza: 99.5%

Colore e forma: Solid

Peso molecolare: 976.96

Ref: 54-BUP00203

Crocin I, 98%

CAS: 42553-65-1

Formula: C₄₄H₆₄O₂₄

Purezza: (HPLC) ≥ 98.0%

Colore e forma: Orange to dark red powder

Peso molecolare: 976.97

Ref: 7W-GY1779

Crocin (Standard)

CAS: 42553-65-1

Crocin (Standard) is the standard substance of Crocin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L. ) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer. Crocin suppresses tumor necrosis factor (TNF)alpha-induced apoptosis of pheochromocytoma (PC12) cells by modulating mRNA expressions of Bcl-2 family proteins, which trigger downstream signals culminating in caspase-3 activation followed by cell death. Crocin prevented the activation of nSMase by enhancing the transcription of gamma-glutamylcysteinyl synthase, which contributes to a stable glutathione supply that blocks the activity of nSMase.

Formula: C₄₄H₆₄O₂₄

Peso molecolare: 976.9646

Ref: TM-TMSM-0823

Crocin

CAS: 42553-65-1

Formula: C₄₄H₆₄O₂₄

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 976.9646

Ref: IN-DA00BXRM

Crocin I

CAS: 42553-65-1

Crocin is a water-soluble carotenoid pigment of saffron (Crocus sativus L.), it has been used as a spice for flavoring and coloring food preparations. Crocin has anti-inflammatory, anti-oxidative, anti-apoptotic, anti-asthma, anti-cancer, and hypolipidemic effects. Crocin improves toxic effects of diazinon via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta; it also protects retinal photoreceptors against light-induced cell death. Crocin can also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3.

Formula: C₄₄H₆₄O₂₄

Purezza: 95%~99%

Peso molecolare: 976.972

Ref: BP-BP0406

Crocin

CAS: 42553-65-1

Stability Light Sensitive
Applications Crocin, is a natural carotenoid derived the flowers crocus and gardenia. Crocin has been shown to be a potent antioxidant. It has also been shown to have an antiproliferative action against cancer cells in vitro, and also possessing possible antidepressant properties.
References Zheng, Y. Q., et al.: Brain Res., 1138, 86 (2006); Hosseinzadeh, H., et al.: PTR, 24 (5), 726 (2010); Ochiai, T., et al.: Biochim. Biophys. Acta., 1770(4), 578 (2006);

Formula: C₄₄H₆₄O₂₄

Colore e forma: Neat

Peso molecolare: 976.96

Ref: TR-C794945

Crocin

CAS: 42553-65-1

(2E,4E,6E,8E,10E,12E,14E)-Bis((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl) 2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate

Formula: C₄₄H₆₄O₂₄

Purezza: 95%

Peso molecolare: 976.96

Ref: IN-DG38996

Crocin

CAS: 42553-65-1

Natural glycoside

Formula: C₄₄H₆₄O₂₄

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 976.98

Ref: 5G-80391

Crocin I

CAS: 42553-65-1

Formula: C₄₄H₆₄O₂₄

Colore e forma: Solid

Peso molecolare: 977.0

Ref: BE-BePure-21470

CrocinⅠ

CAS: 42553-65-1

Formula: C₄₄H₆₄O₂₄

Colore e forma: Solid

Peso molecolare: 977.0

Ref: BE-RMT19100

Crocin

CAS: 42553-65-1

Purezza: 95%

Peso molecolare: 976.972

Ref: 10-F979316

Crocin I

CAS: 42553-65-1

Crocin is a pharmaceutical product which is an antipyretic and analgesic medication, primarily composed of paracetamol (acetaminophen). It is synthesized through chemical processes originally derived from coal tar, although modern production predominantly utilizes petrochemical sources. The mode of action of Crocin involves the inhibition of cyclooxygenase (COX) enzymes, particularly COX-2, in the central nervous system. This action leads to a decrease in the synthesis of prostaglandins, which are responsible for pain and fever.

Formula: C₄₄H₆₄O₂₄

Purezza: Min. 98.0 Area-%

Colore e forma: Powder

Peso molecolare: 976.96 g/mol

Ref: 3D-OC08286

Crocin - microscopy grade

CAS: 42553-65-1

Crocin is a carotenoid found in the fruit of Crocus sativus. It has been shown to have potential anticancer activity, as well as antioxidant and anti-inflammatory properties. Crocin has demonstrated significant cytotoxicity against cancer cells in vitro. The mechanism of action is not fully understood, but it may be due to its ability to inhibit oxidative injury and receptor activity. Crocin has also been shown to have an effect on eye disorders such as retinitis pigmentosa and macular degeneration, which may be due to its antioxidant properties. The analytical method for crocin is high performance liquid chromatography (HPLC). HPLC separation is achieved using a reversed-phase column with gradient elution using water, acetonitrile and methanol. Preparative HPLC is used for isolation from natural sources.

Formula: C₄₄H₆₄O₂₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 976.96 g/mol

Ref: 3D-FC158408