CAS 47931-85-1

Calcitonina (salmone)

Descrizione:

Calcitonina (salmone) è un ormone peptidico che gioca un ruolo cruciale nell'omeostasi del calcio e nel metabolismo osseo. È derivato dalla specie di salmone, che ha una forma più potente rispetto alla calcitonina umana. Questa sostanza è composta da 32 aminoacidi ed è nota per la sua capacità di abbassare i livelli di calcio nel sangue inibendo l'attività degli osteoclasti, riducendo così il riassorbimento osseo. La calcitonina promuove anche l'escrezione renale di calcio e fosfato, contribuendo ulteriormente ai suoi effetti ipocalcemici. Viene comunemente utilizzata in contesti clinici per il trattamento di condizioni come l'osteoporosi e la malattia di Paget. Il numero CAS 47931-85-1 identifica in modo univoco questa specifica formulazione di calcitonina. In termini di proprietà fisiche, Calcitonina (salmone) viene tipicamente somministrato per iniezione a causa della sua natura peptidica, che limita la sua biodisponibilità se assunto per via orale. I suoi effetti terapeutici sono generalmente rapidi, rendendolo un'opzione preziosa nella gestione dell'ipercalcemia e dei disturbi correlati.

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

InChI: InChI=1/C145H240N44O48S2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157)

SMILES: CC(C)CC(C(=NCC(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CO)C(=NC(CCC(=N)O)C(=NC(CCC(=O)O)C(=NC(CC(C)C)C(=NC(Cc1cnc[nH]1)C(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CCC(=N)O)C(=NC(C(C)O)C(=NC(Cc1ccc(cc1)O)C(=O)N1CCCC1C(=NC(CCCNC(=N)N)C(=NC(C(C)O)C(=NC(CC(=N)O)C(=NC(C(C)O)C(=NCC(=NC(CO)C(=NCC(=NC(C(C)O)C(=O)N1CCCC1C(=N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(C(C)C)N=C(C1CSSCC(C(=NC(CO)C(=NC(CC(=N)O)C(=NC(CC(C)C)C(=NC(CO)C(=NC(C(C)O)C(=N1)O)O)O)O)O)O)N)O)O

Sinonimi:

• Calcitonin (salmon I)
• Thyrocalcitonin Salmon
• H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide bond)
• Thyrocalcitonin
• Salmon calcitonin
• Salcitonin
• Salmon Calcitonin acetate
• Salmon
• Calcitonin salmon Acetate
• Calciben
• Calcimar
• Calcitonin (Lachs)
• Calcitonin (salmon reduced) cyclic (1→7)-disulfide
• Calcitonina (Salmon)
• Calcitonine (Saumon)
• Calsyn
• Calsynar
• Catonin
• Karil
• L-Prolinamide, L-cysteinyl-L-seryl-L-asparaginyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparaginyl-L-threonylglycyl-L-serylglycyl-L-threonyl-, cyclic (1→7)-disulfide
• Miacalcic
• Miacalcin
• Miadenil
• Prontocalcin
• Rulicalcin
• Salcatonin
• Salmon calcitonin I
• Salmon calcitonin-(1-32)
• Salmon Thyrocalcitonin
• Salmotonin
• Stalcin
• Tonocalcin
• Calcitonin(Salmone) Acetate

Calcitonin (salmon I)

CAS: 47931-85-1

Calcitonin inhibits osteoclast activity, lowers the blood calcium level, and positively influences bone mass density. Salmon calcitonin (sCT) is more potent than the human analog. sCT may act as an amylin agonist (Wielinga et al.). In animal studies, administration of sCT was shown to reduce food intake.

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Purezza: 99.3%

Colore e forma: White Lyophilisate

Peso molecolare: 3431.9

Ref: 01-4033011

CALCITONIN-GLY CRS

CAS: 115472-96-3, 47931-85-1

CALCITONIN-GLY CRS

Ref: 41-Y0000632

CALCITONIN (SALMON) CRS

CAS: 47931-85-1

CALCITONIN (SALMON) CRS

Formula: C₈H₆BrN

Peso molecolare: 196.0439

Ref: 41-C0200000

Calcitonin Salmon

CAS: 47931-85-1

Polypeptide, protein and glycoprotein hormones, their derivatives and structural analogues, nesoi

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Colore e forma: White Off-White Powder

Peso molecolare: 3429.71331

Ref: 45-1086200

Calcitonin (Salmon)

CAS: 47931-85-1

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Peso molecolare: 3431.90

Ref: 4Z-PC-322001

Calcitonin Salmon

CAS: 47931-85-1

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Purezza: >95.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 3,431.90

Ref: 3B-C3597

Calcitonin (salmon)

CAS: 47931-85-1

Calcitonin (salmon), a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Purezza: 99.41% - 99.80%

Colore e forma: Powder

Peso molecolare: 3431.85

Ref: TM-TP1040

Calcitonin Acetate(Salmon)

CAS: 47931-85-1

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Purezza: 95%~99%

Colore e forma: White to Off-white Powder

Peso molecolare: 3431.85

Ref: BP-BPPG013

Calcitonin Salmon RS

CAS: 47931-85-1, 5989-81-1

Colore e forma: White Solid

Ref: 2K-1039500021

Calcitonin, Salmon

CAS: 47931-85-1

Applications Calcitonin, Salmon is a calcium regulating hormone which exhibits hypocalcaemic and hypophosphatemic properties.

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Colore e forma: Neat

Peso molecolare: 3431.85

Ref: TR-C144558

N-Acetyl-cys(1)-calcitonin Salmon Trifluoroacetic Acid Salt

Prodotto controllato

CAS: 47931-85-1

Applications N-Acetyl-cys(1)-calcitonin Salmon is a derivative of Calcitonin (salmon), is a 32-amino acid linear polypeptide hormone that is produced in thyroid in humans. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).
References Boron, WF., et al.: Med. Physi., A Cellular and Molecular Approach (2004); Andreotti, G. et al.: J. Bio. Chem., 281, 24193 (2006);

Formula: C₁₄₇H₂₄₃N₄₄O₄₉S₂·x(C₂HF₃O₂)

Colore e forma: Neat

Peso molecolare: 3475.5911402

Ref: TR-A168465

Calcitonin (salmon) xAcetate

Prodotto controllato

CAS: 47931-85-1

Applications Calcitonin (salmon), is a 32-amino acid linear polypeptide hormone that is produced in thyroid in humans. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).
References Boron, WF. et al.: Med. Phys., A Cellular and Molecular Approach (2004); Andreotti, G. et al.: J. Bio. Chem., 281, 24193 (2006);

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂·x(CH₃CO₂H)

Colore e forma: Neat

Peso molecolare: 3431.856005

Ref: TR-C144555

Calcitonin

CAS: 47931-85-1

Calcitonin is a peptide hormone that inhibits the release of calcium from bone, and decreases the blood level of calcium. Calcitonin is not active in the absence of parathyroid hormone (PTH) or vitamin D. It has been shown to inhibit the development of experimental myocardial infarcts in rats by inhibiting the release of calcium from bone, and has also been shown to have a protective effect on brain function. The calcitonin receptor is activated by binding with calcitonin, which then activates adenylyl cyclase and increases intracellular cAMP levels. This leads to increased activity at ATP-sensitive potassium channels, which causes hyperpolarisation of neurons. Caudate putamen neurons are particularly sensitive to calcitonin activity because they are rich in voltage-gated K+ channels that are sensitive to ATP-sensitive potassium channel activation. Calcitonin also plays a role in regulating serum Ca2+ concentration by inhib

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Purezza: Min. 95%

Peso molecolare: 3,431.86 g/mol

Ref: 3D-FC36651

Calcitonin (salmon)

CAS: 47931-85-1

Calcitonin (salmon)

Colore e forma: White Powder

Ref: 47-355